Identification and characterization of three members of the human SR family of pre-mRNA splicing factors

EMBO Journal

Volumn 14, Issue 17, 1995, Pages 4336-4349

  Screaton, Gavin R ^a   Cáceres, Javier F ^b   Mayeda, Akila ^b   Bell, Martyn V ^a   Plebanski, Magda ^a   Jackson, David G ^a   Bell, John I ^a   Krainer, Adrian R ^b  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Alternative splicing; RNA splicing; SR proteins

Indexed keywords

ARGININE; CD45 ANTIGEN; COMPLEMENTARY DNA; HERMES ANTIGEN; MESSENGER RNA; MESSENGER RNA PRECURSOR; NUCLEAR PROTEIN; PHOSPHOPROTEIN; RECOMBINANT PROTEIN; SERINE; VIRUS PROTEIN;

ADENOVIRUS; ALTERNATIVE RNA SPLICING; ARTICLE; BETA THALASSEMIA; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA TRANSFECTION; DROSOPHILA; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; T LYMPHOCYTE ACTIVATION;

ADENOVIRIDAE;

EID: 0028831527     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1995.tb00108.x     Document Type: Article

References (35)

1. Ayane,M., Preuss,U., Kohler,G. and Nielsen,P.J. (1991) A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res., 19, 1273-1278.
2. Bandziulis,R.J., Swanson,M.S. and Dreyfuss,G. (1989) RNA-binding proteins as developmental regulators. Genes Dev., 25, 431-437.
3. Birney,E., Kumar,S. and Krainer,A.R. (1993) Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res., 21, 5803-5816.
4. Bossie,M.A., DeHoratius,C., Barcelo,G. and Silver,P. (1992) A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast. Mol. Biol. Cell., 3, 875-893.
5. Cáceres,J.F. and Krainer,A.R. (1993) Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J., 12, 4715-1726.
6. Cáceres,J.F., Stamm,S., Helfman,D.M. and Krainer,A.R. (1994) Regulation of alternative splicing by overexpression of antagonistic splicing factors. Science, 265, 1706-1709.
7. Cardinali,B., Cohen,P.T.W. and Lamond,A.I. (1994) Protein phosphatase 1 can modulate alternative 5′ splice site selection in a HeLa splicing extract. FEBS Lett., 352, 276-280.
8. Cavaloc,Y., Popielarz,M., Fuchs,J.P., Gattoni,R. and Stévenin,J. (1994) Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. EMBO J., 13, 2639-2649.
9. Champlin,D.T., Frasch,M., Saumweber,H. and Lis,J.T. (1991) Characterization of a Drosophila protein associated with boundaries of transcriptionally active chromatin. Genes Dev., 5, 1611-1621.
10. Deans,J.P., Boyd,A.W. and Pilarski,L.M. (1989) Transitions from high to low molecular weight isoforms of CD45 (T200) involve rapid activation of alternate mRNA splicing and slow turnover of surface CD45R. J. Immunol., 143, 1233-1238.
11. Diamond,R.H., Du,K., Lee,V.M., Mohn,K.L., Haber,B.A., Tewari,D.S. and Taub,R. (1993) Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing. J. Biol. Chem., 268, 15185-15192.
12. Eperon,J.C., Ireland,D.C., Smith,R.A., Mayeda,A. and Krainer,A.R. (1993) Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF. EMBO J., 12, 3607-3617.
13. Fox,S.B., Fawcett,J., Jackson,D.G., Collins,I., Gatter,K.C., Harris,A.L., Gearing,A. and Simmons,D.L. (1994) Normal human tissues, in addition to some tumors, express multiple different CD44 isoforrns. Cancer Res., 54, 4539-4546.
14. Fu,X.-D. (1993) Specific commitment of different pre-mRNAs to splicing by single SR proteins. Nature, 365, 82-85.
15. Fu,X.-D. and Maniatis,T. (1992a) The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3′ splice site. Proc. Natl Acad Sci USA, 89, 1725-1729.
16. Fu,X.-D. and Maniatis,T. (1992b) Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science, 256, 535-538.
17. Fu,X.-D., Mayeda,A., Maniatis,T. and Krainer,A.R. (1992) General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5′ and 3′ splice site selection. Proc. Natl Acad. Sci. USA, 89, 11224-11228.
18. Ge,H., Zuo,P. and Manley,J.L. (1991) Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell, 66, 373-382.
19. Gui,J.F., Lane,W.S. and Fu,X.-D. (1994) A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature, 369, 678-682.
20. Harper,J.E. and Manley,J.L. (1992) Multiple activities of the human splicing factor ASF. Gene Expr., 2, 19-29.
21. Jackson,D.G. et al. (1995) Structure of the CD44 gene and its expression during lymphocyte activation. In Schlossman,S.F. (ed.), 5th International Human Leukocyte Differentiation Antigen Workshop Handbook. Oxford University Press, Oxford, UK, pp. 1727-1729.
22. Jiménez-García,L.F. and Spector,D.L. (1993) In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism. Cell, 73, 47-59.
23. Kenan,D.J., Query,C.C. and Keene,J.D. (1991) RNA recognition: towards identifying determinants of specificity. Trends Biochem. Sci., 16, 214-220.
24. Kim,Y.-G., Zuo,P., Manley,J.L. and Baker,B.S. (1992) The Drosophila RNA-binding protein RBP1 is localised to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2. Genes Dev., 6, 2569-2579.
25. Kohtz,J.D., Jamison,S.F., Will,C.L., Zuo,P., Lührmann,R., García-Blanco,M.A. and Manley,J.L. (1994) Protein-protein interactions and 5′-splice-site recognition in mammalian mRNA precursors. Nature, 368, 119-124.
26. Krainer,A.R., Maniatis,T., Ruskin,B. and Green,M.R. (1984) Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell, 36, 993-1005.
27. Krainer,A.R., Conway,G.C. and Kozak,D. (1990) The essential premRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites. Genes Dev., 4, 1158-1171.
28. Krainer,A.R., Mayeda,A., Kozak,D. and Binns,G. (1991) Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1-70K, and Drosophila splicing regulators. Cell, 66, 383-394.
29. Lamm,G.M. and Lamond,A.I. (1993) Non-snRNP protein splicing factors. Biochim. Biophys. Acta, 1173, 247-265.
30. Lavigueur,A., La Branche,H., Kornblihtt,A.R. and Chabot,B. (1993) A splicing enhancer in the human fibronectin ED1 exon interacts with SR proteins and stimulates snRNP binding. Genes Dev., 7, 2405-2417.
31. Mattox,W., Ryner,L. and Baker,B.S. (1992) Autoregulation and multifunctionality among trans-acting factors that regulate alternative pre-mRNA processing. J. Biol. Chem., 267, 19023-19026.
32. Mayeda,A. and Krainer,A.R. (1992) Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell, 68, 365-375.
33. Mayeda,A., Zahler,A.M., Krainer,A.R. and Roth,M.B. (1992) Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proc. Natl Acad. Sci. USA, 89, 1301-1304.
34. Mayeda,A., Helfman,D.M. and Krainer,A.R. (1993) Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol. Cell. Biol., 13, 2993-3001.
35. Mayeda,A., Munroe,S.H., Cáceres,J.F. and Krainer,A.R. (1994) Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J., 13, 5483-5495.