Cellular accumulation of antineoplaston AS21 in human hepatoma cells

Cancer Letters

Volumn 88, Issue 1, 1995, Pages 107-112

  Sołtysiak Pawłuczuk, Dorota ^a   Burzyński, Stanisław R ^a  

^a Burzynski Research Institute Inc   (United States)

Author keywords

Antineoplaston AS21; Hep G2 cells; Human hepatoma cell line; Phenylacetic acid; Phenylacetylglutamine; Uptake systems

Indexed keywords

4 AMINOHIPPURIC ACID; ANION; ANTINEOPLASTON AS2-1; CARRIER PROTEIN; CHOLINE; GLUTAMINE; GLUTAMINE DERIVATIVE; HISTIDINE; LITHIUM ION; PHENYLACETIC ACID; PROBENECID; SODIUM ION; STILBENE;

AMINO ACID TRANSPORT; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG TRANSPORT; DRUG UPTAKE; HEP 2 CELL; HEPATOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY;

ANIONS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CARCINOMA, HEPATOCELLULAR; DRUG COMBINATIONS; GLUTAMINE; HUMAN; IN VITRO; PHENYLACETATES; SODIUM; TEMPERATURE; TUMOR CELLS, CULTURED;

PAA;

EID: 0028831351     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(94)03621-O     Document Type: Article

References (19)

1. Phenyl acetic acid in human body fluids: high correlation between plasma and cerebrospinal fluid concentration values
2. synthesis of phenylacetylglutamine by human tissue
3. Waste nitrogen excretion via amino acid acylation: benzoate and phenylacetate in lysinuric protein intolerance
4. Treatment of hormonally refractory cancer of the prostate with antineoplaston AS2-1
5. A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer
6. Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria
7. Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate
8. Uptake characteristics of antineoplaston AS2-1 by human hepatoma cells
9. Antineoplaston A 10
10. Protein measurement with the folin phenol reagent
11. Cell differentiation and bypassing of genetic defects in suppression of malignancy
12. Differentiation therapy of leukemia
13. Butyrate as a differentiating agent: pharmacokinetics, analogues and current status
14. Phenylacetate: a novel nontoxic inducer of tumor cell differentiation
15. Induction of erythroid differentiation and fetal hemoglobin production in human leukemic cells treated with phenylacetate
16. Effects of phenylacetate on cells from patients with β-chronic lymphocytic leukemia
17. Hep G2 cells: An in vitro model for P450-dependent metabolism of acetaminophen
18. Glutamine transport across biological membranes
19. Metabolic basis for differentiatial glutamine requirements of human leukemia cell line