Iron mediates trichomonas vaginalis resistance to complement lysis

Microbial Pathogenesis

Volumn 19, Issue 2, 1995, Pages 93-103

  Alderete, John F ^a   Provenzano, Daniele ^a   Lehker, Michael W ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS AT EL PASO   (United States)

Author keywords

Complement; Host parasite; Trichomonas vaginalis; Virulence

Indexed keywords

COMPLEMENT; IRON; PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; HOST PARASITE INTERACTION; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; R FACTOR; TRICHOMONAS VAGINALIS;

ANIMAL; COMPLEMENT 3; CYSTEINE ENDOPEPTIDASES; HUMAN; IRON; SUPPORT, U.S. GOV'T, P.H.S.; TRICHOMONAS VAGINALIS;

ANIMALIA; TRICHOMONAS VAGINALIS;

EID: 0028827837     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1006/mpat.1995.0049     Document Type: Article

References (36)

1. Demes P, GomboSova A, Valent M, Janoska A, Fabusova H, Petrenko M. Differential susceptibility of fresh Trichomonas vaginalis isolates to complement in menstrual blood and cervical mucus. Gen-itourin Med 1988b; 64: 176-9.
2. Gillin FD, Sher H. Activation of the alternative complement pathway by Trichomonas vaginalis. Infect Immun 1981; 34: 268-73.
3. Holbrook TW, Boakle RJ, Vesely J, Parker BW. Trichomonas vaginalis: Alternative pathway activation of complement. Trans R Soc Trop Med Hyg 1982; 76: 473-5.
4. Reisenhover V. Uber die Beeinflussing von Trichomonas vaginalis durch verschiedene Sera. Arch Hyg Bakteriol 1963; 146: 628-35.
5. Weld JT, Kean BH. A factor in serum of human beings and animals that destroys T. vaginalis. Proc Soc Exp Biol Med 1958; 98: 494-6.
6. Demes P, Gombosova A, Valent M, Fabusova H, Janoska A. Fewer Trichomonas vaginalis organisms in vaginas of infected women during menstruation. Genitourin Med 1988a; 64: 22-4.
7. Alderete JF, O’Brien JL, Arroyo R et al. Cloning and molecular characterization of two genes encoding adhesion proteins involved in Trichomonas vaginalis cytoadherence. Molec Microbiol 1995; 17: 6983.
8. Lehker MW, Arroyo R, Alderete JF. The regulation by iron of the synthesis of adhesins and cytoadherence levels in the protozoan Trichomonas vaginalis. J Exp Med 1991; 174: 311-8.
9. Lehker MW, Alderete JF. Iron regulates growth of Trichomonas vaginalis and the expression of immunogenic trichomonad proteins. Mol Microbiol 1992; 6: 123-32.
10. Alderete JF, Kasmala L, Metcalfe E, Garza GE. Phenotypic variation and diversity among Trichomonas vaginalis and correlation of phenotype with trichomonal virulence determinants. Infect Immun 1986; 53: 285-93.
11. Gorrell TE. Effect of culture medium iron content on the biochemical composition and metabolism of Trichomonas vaginalis. J Bacteriol 1985; 161: 1228-30.
12. Alderete JF. Antigen analysis of several pathogenic strains of Trichomonas vaginalis. Infect Immun 1983; 39: 1041-7.
13. Dailey DC, Chang TH, Alderete JF. Characterization of Trichomonas vaginalis haemolysis. Parasitol 1990; 101: 171-5.
14. Peterson KM, Alderete JF. Iron uptake and increased intracellular enzyme activity follow host lac-toferrin binding by Trichomonas vaginalis. J Exp Med 1984; 160: 398-410.
15. Coombs GH, North MJ. An analysis of the proteinases of Trichomonas vaginalis by polyacrylamide gel electrophoresis. Parasitol 1983; 86: 1-6.
16. Lockwood BC, North MJ, Scott KI, Bremmer AF, Coombs GH. The use of a highly sensitive electrophoretic method to compare the proteinases of trichomonads. Mol Biochem Parasitol 1987; 24: 89-95.
17. Neale KA, Alderete JF. Analysis of the proteinases of representative Trichomonas vaginalis isolates. Infect Immun 1990; 58: 157-62.
18. North MJ, Robertson CD, Coombs GH. The specificity of trichomonad cysteine proteinases analyzed using fluorogenic substrates and specific inhibitors. Mol Biochem Parasit 1990; 39: 183-94.
19. Peterson KP, Alderete JF. Host plasma proteins on the surface of pathogenic Trichomonas vaginalis. Infect Immun 1982; 37: 755-62.
20. Krieger JN. Urologic aspects of trichomoniasis. Invest Urol 1981; 18: 411-7.
21. Rein MF, Chapel TA. Trichomoniasis, candidiasis and the minor venereal diseases. Clin Obstet Gynecol 1975; 18: 73-88.
22. Schumacher GFB, Kim MH, Hosseinian AH, Dupon C. Immunoglobulins, proteinase inhibitors, albumin, and lysozyme in human cervical mucus. Am J Obstet Gynecol 1977; 129: 629-36.
23. Joiner KA. Complement evasion by bacteria and parasites. Ann Rev Microbiol 1988; 42: 201-30.
24. Alderete JF, Newton E, Dennis C, Neale KA. The vagina of women infected with Trichomonas vaginalis has numerous proteinases and antibody to trichomonad proteinases. Genitourin Med 1991; 67: 46974.
25. Arroyo R, Alderete JF. Trichomonas vaginalis proteinase activity is necessary for parasite cytoadherence. Infect Immun 1989; 57: 2991-6.
26. Provenzano D, Alderete JF. Analysis of human immunoglobulin-degrading cysteine proteinases of Trichomonas vaginalis. Infect Immun 1995; 63: 3388-95.
27. Hardy PH, Hardy JB, Nell EE, Graham DA, Spence MR, Rosenbaum RC. Prevalence of six sexually transmitted disease agents among pregnant inner-city adolescents and pregnancy outcome. Lancet 1984; Vol II: 333-7.
28. Laga M, Alary M, Nzila N, et al. Condom promotion, sexually transmitted diseases treatment, and declining incidence of HIV-1 infection in female Zairian sex workers. Lancet 1994; 344: 246-8.
29. Laga M, Manoka A, Kivuvu M, et al. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS 1993; 7: 95-102.
30. Vuylsteke B, Bastos R, Barreto J, et al. High prevalence of sexually transmitted diseases in a rural area in Mosambique. Genitourin Med 1993; 69: 428-30.
31. Diamond LS. The establishment of various trichomonads of animals and man in axenic cultures. J Parasitol 1957; 43: 488-90.
32. Fine DP, Marney SR, Colley DG, Sergent JS, Des Prez RM. C3 shunt activation in human serum chelated with EGTA. J Immunol 1972; 109: 807-9.
33. Peterson KM, Alderete JF. Acquisition of a,-antitrypsin by a pathogenic strain of Trichomonas vaginalis. Infect Immun 1983; 40: 640-6.
34. Fuhrman SA, Joiner KA. Toxoplasma gondii: Mechanism of resistance to complement-mediated killing. J Immunol 1989; 142: 940-7.
35. 131I-labeled proteins. In: Campbell, D. H., Ed. Methods in Immunology. Reading, MA: Benjamin, W.A., Inc., 1977: 171-82.
36. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.