Enzymatic degradation of glycosaminogiycans

Critical Reviews in Biochemistry and Molecular Biology

Volumn 30, Issue 5, 1995, Pages 387-444

  Ernst, Steffen ^a   Langer, Robert ^a   Cooney, Charles L ^a   Sasisekharan, Ram ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Hydrolase; Kinetics; Lyase; Mechanism; Polysaccharide; Structure; Sulfation

Indexed keywords

CHONDROITIN; CHONDROITIN 4 SULFATE; CHONDROITIN 6 SULFATE; DERMATAN SULFATE; GALACTOSIDASE; GLYCOSAMINOGLYCAN; GLYCOSIDASE; HEPARAN SULFATE; HEPARIN; HEPARIN LYASE; HYALURONIC ACID; HYALURONIDASE; HYDROLASE; IDURONIC ACID; KERATAN SULFATE; LYASE; N ACETYLGALACTOSAMINE 4 SULFATASE; OLIGOSACCHARIDE; PECTATE LYASE;

CATALYSIS; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EXTRACELLULAR MATRIX; HYDROGEN BOND; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS; SULFATION;

ANIMAL; CARBOHYDRATE SEQUENCE; GLYCOSAMINOGLYCANS; HUMAN; HYDROLASES; LYASES; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; SUBSTRATE SPECIFICITY; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028827060     PISSN: 10409238     EISSN: None     Source Type: Journal    
DOI: 10.3109/10409239509083490     Document Type: Article

References (275)

1. Subsite mapping of enzymes: application to polysaccharide depolymerases
2. Disaccharide compositional analysis of heparin and heparan sulfate using capillary zone electrophoresis
3. Conformation of keratan sulphate
4. Affinity of the gastric pathogen Helicobacter pylorifor the N-sulphated glycosaminoglycan heparan sulphate
5. Contribuiton of monosaccharide residues in heparin binding to antithrombin III
6. Heparin: crystalline structures of the sodium and calcium salts
7. Biosynthesis of skeletal and corneal keratan sulphate
8. Release of heparan sulfate glycosami-noglycans from proteoglycans in Chinese hamster ovary cells does not require proteolysis of the core protein
9. Heparinase in the activated clotting time assay: monitoring heparin-independent alterations in coagulation function
10. Heparinase produced by a microorganism belonging to the genus Bacillus
11. A novel Bacillussp. capable of degrading sulfated glycosaminoglycans
12. Specificity in the binding domain of glucoamylase 1
13. A modified uronic acid carbazole reaction
14. Purification and characterization of a novel heparinase
15. Glycosaminoglycans and the regulation of blood coagulation
16. Isolation and characterization of the glycosaminoglycan component of rabbit thrombomodulin proteoglycan
17. Calcium chondroitin 4-sulfate: Molecular conformation and organization of polysaccharide chains in a proteoglycan
18. Molecular design and modeling of protein-heparin interactions
19. Molecular modeling of protein-glycosaminoglycan interactions
20. Structure of heparin and heparin fragments
21. Controversial glycosaminoglycan conformations
22. Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans
23. Alzheimer's desease: the proteoglycans hypothesis
24. Sulfur regulation of heparinase and sulfatases in Flavobacterium heparinum
25. A new method for sequence analysis of glycosaminoglycans from heavily substituted proteoglycans reveals non-random positioning of 4– and 6–0-sulphated N-acetylgalactosamine in aggrecan-derived chondroitin sulphate
26. Randomness in the heparin polymer: Computer simulations of alternative action patterns of heparin lyase
27. The parallel p helix of pectate lyase C: something to sneeze at
28. Biochemical bases of the interaction of human basic fibroblast growth factor with the glycosaminoglycans
29. Structure of heparan sulfate and dermatan sulfate
30. Modes of FGF release in vivo and in vitro
31. Cell mutants defective in synthesizing a heparan sulfate proteoglycan with regions of defined monosaccharide sequence
32. Specificity studies on the heparin lyases from Flavobacterium heparinum
33. Substrate specificity of the heparin lyases from Flavobacterium heparinurn
34. Sequential degradation of heparin in Flavobacterium heparinum
35. Heparin, non-heparin glycosaminogly-cans, and heparinoids: An overview of their application in atherosclerosis
36. Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-a-inhibitor
37. Three-dimensional structure of human basic fibroblast growth factor
38. Expression, purification, and characterization of heparinase I from F. heparinumin E. coli. Submitted to
39. A unique heparan sulfate in the nuclei of hepatocytes: Structural changes with the growth state of the cells
40. Conformer populations of L-iduronic acid residues in glycosaminoglycan sequences
41. On the solid-state conformation of glycosaminoglycans containing iduronic acid
42. Angiogenic Factors
43. Mammalian Glycosaminoglycans
44. Interaction between dermatan sulphate chains
45. Self-associatin of heparan sulfate
46. A method for the sequence analysis of dermatan sulphate
47. Computer modeling of carbohydrates
48. Calcium destabilizes and causes conformational changes in hyaluronic acid
49. Structure and function of heparan sulphate proteoglycans
50. Hepm sulphate proteoglycans: molecular organisation of membrane-associated species and an approach to polysac-charide sequence analysis
51. Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme
52. Molecular distinctions between heparan sulphate and heparin
53. One- and two-dimensional 13 C-n.m.r characterization of two series of oli-gosaccharides derived from porcine intestinal mucosal heparin by degradation with heparinase
54. The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules
55. Heparanase activity in cultured endothelial cells
56. Heparin protects basic and acidic FGF from inactivation
57. Studies on the mechanism of hyaluronate lyase action
58. Constructing a molecular model of the interaction between antithrombin III and a potent heparin analogue
59. Carbohydrates and drug discovery —the role of computer simulation
60. Monoclonal antibodies prepared against heparin lyase I and their reactivity toward heparin lyase I, II, and III
61. Comparison of the activity of two chondroitin AC lyases on dermatan sulfate
62. Activating and inhibitory heparin sequences for FGF-2 (Basic FGF)
63. The disaccharide composition of heparins and heparan sulfates
64. Hyaluronic acid: molecular conformations and interactions in two sodium salts
65. Cloning and expression in Escherichia coliof a gene coding for a chondroitin lyase from Bacreroides thetaiotaomicron
66. The conformation of six-mem-bered rings described by puckering coordinates derived from endocyclic torsion angles
67. Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factor
68. Purification and characterization of hyaluronidase from Streptococcus dysgalactiae
69. Proteoglycans: many forms and many functions
70. Glycosylation
71. Keratan sulphate proteoglycans: chemistry biosynthesis of linkage regions
72. A water molecule participates in the secondary structure of hyaluronan
73. Mechanism of action of bovine testicular hyaluronidase
74. Heparin
75. Amino Acid composition and physicochemical characterization of chondroitinase from Arthrobacter aurescens
76. . Crystallization and some properties of chondroitinase from Arthrobacter aurescens
77. Action of Chondroitinases I
78. Action of Chondroitinases III
79. Enzymes that degrade heparin and heparan sulphate
80. Structural and conformational analysis of kentan sulphate oligosaccharides and related carbohydrate structures
81. 1H-NMR studies at 500 MHz of a neutral disaccharide and sulphated di-, tetra-, hexa-, and larger oligosaccharides obtained by endo-β-galactosidase treatment of keratan sulphate
82. Binding of calcium to glycosaminoglycans: an equilibrium dialysis study
83. Analysis of two chondroitin sulfate utilization mutants of Bacteroides thetaiotamicronthat differ in their abilities to compete with the wild type in the gastrointestinal tracts of germfree mice
84. Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: Role of extracellular matrix
85. Borrelia burgdorferibind to epithelial cell proteoglycans
86. Heparanase activity expressed by platelets, neutrophils and lymphoma cells releases active fibroblast growth factor from extracellular matrix
87. Transport of heparan sulfate into the nuclei of hepatocytes
88. Involvement of phosphatidylinositol and insulin in the coordinate regulation of proteoheparan sulfate metabolism and hepatocyte growth
89. Preparation of affinity-fractionated, heparin-derived oligosaccharides and their effects on selected biological activities mediated by basic fibroblast growth factor
90. Heparan sulfate proteoglycans are required for mesoderm formation in Xenopusembryos
91. Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes
92. Action patterns of polysaccharide lyases on glycosaminoglycans
93. Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction
94. On the attribution and additivity of binding energies
95. A constitutive heparinase in a Flavobacteriumsp
96. Mass spectrometric molecular weight determination of highly acidic compounds of biological significance via their complexes with basic polypeptides
97. An essential heparin-binding domain in the fibroblast growth factor receptor kinase
98. The purification and characterization of hyaluronidase from the venom of the honey bee, Apis mellifera
99. The molecular biology of heparan sulfate fibroblast growth factor receptors
100. Mechanism and stereoelectronic effects in the lysozyme reaction
101. Chondroitinase-pro-ducing bacteria in natural habitats
102. Proteoglycans: structures and interactions
103. A dual receptor system is required for basic fibroblast growth factor activity
104. Isolation and characterization of heparan sulfate proteoglycans produced by cloned rat microvascular endothelial cells
105. Degradation of keratan sulphate proteoglycans
106. Glycosaminoglycan degradation
107. 1H and 13C NMR studies of solutions of hyaluronic acid esters and salts in methyl sulfoxide: comparison of hydrogen-bond patterns and conformational behaviour
108. An enzymatic system for removing heparin in extracorporeal therapy
109. Production of heparanase by normal and neoplastic murine B-lymphocytes
110. Analysis of affinity and structural selectivity in the binding of proteins to gly-cosaminoglycans: development of a sensitive electro-phoretic approach
111. Biosynthesis of heparin and related polysac-charides
112. Biosynthesis of heparin and heparan sulfate
113. More to “heparin” than anticoagulation
114. Extension and smctural variability of the antithrombin-binding sequence in heparin
115. Domain structure of endothelial heparan sulphate
116. Analysis of glycosaminoglycans with polysaccharide lyases
117. Structural features of dermatan sulfates and their relationship to anticoagulant and antithrombotic activities
118. Isolation and characterization of human heparin
119. Mode of action of heparin lyase on heparin
120. Polysaccharide lyases
121. Evidence of random structural features in the heparin polymer
122. Homogeneous, structurally defined heparin-oligosaccharides with low anticoagulant activity inhibit the generation of the amplification pathway C3 convertase in vitro
123. Mapping and quantification of the major oligosaccharide components of heparin
124. Examination of the substrate specificity of heparin and heparan sulfate lyases
125. Search for the heparin antithrombin III-binding precursor
126. New methodologies in heparin structure analysis and the generation of LMW heparins
127. Heparinase and heparitinase from Flavobacteria
128. Isolation and characterization of two chondroitin lyases from Bacteroides thetaiotamicron
129. Structural variation in the antithrombin III binding site region and its occurence in heparin from different sources
130. Purification and characterization of heparin lyases from Flavobacterium heparinum
131. Binding of inter-feron-gammma to heparan sulfate is restricted to the heparin-like domains and involves carboxylic — but not N-sulfated— groups
132. Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants
133. Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor
134. A model for the action of cereal alpha amylases on amylose
135. Structure of a dermatan sulfate hexasaccharide that binds to heparin co-factor II with high affinity
136. The biochemistry, cell biology, and patophysiology of anticoagulantly active heparin-like molecules of the vessel wall
137. Role of endothelial cell surface heparin-like polysaccharides
138. aFGF binding to low and high affinity receptors induces both aFGF and aFGF receptors dimerization
139. Enzymes metabolizing polysaccharides and their application to the analysis of structure and function of glycans
140. Subcellular localization of heparanase in human neutrophils
141. A comparative study between a chondroitinase B and a chondroitinase AC from Flavobacterium heparinum
142. Chondroitinase C from Flavobacterium heparinum
143. Isolation and characterization of an induced chondroitinase ABC from Flavobacterium heparinum
144. Chondroitin 4-sulfate: comparison of the structures of the potassium and sodium salts
145. Dermatan sulfate: molecular conformations and interactions in the condensed state
146. Heparinase II from Flavobacterium heparinum —action on chemically modified heparins
147. Heparinase II from Flavobacterium heparinum: HPLC analysis of the saccharides generated from chemically modified heparins
148. Conformation and dynamic interactions in hyaluronate solutions
149. Crystal structure of cleaved bovine antithrombin III at 3.2 Å resolution
150. N.m.r. and molecular-modeling studies of the solution conformation of heparin
151. Characterization of the products generated from oversulphated dermatan sulphate isomers with chondroitinase-B high-performance liquid chromatography
152. Natural Occurence and possible biological role of heparin
153. Heparin sequence in the heparan sulfate chains of an endothelial cell proteoglycan
154. Purification and substrate specificity of heparitinase I and heparitinase II from Flavobacterium heparinum
155. Studies on the enzyme chondroitinase: product structure and ion effects
156. Isolation and characterization of an endo-β-galactosidase from a new swain of Escherichia freundii
157. Metastatic melanoma cell heparanase
158. Tumor meastasis-associated heparanase activity in human melanoma cells
159. Heparanases and tumor metastasis
160. Purification and properties of Bacteroides heparinolyticusheparinase
161. Substrate specificity of keratan sulphate-degrading enzymes from microorganisms
162. Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation
163. Connective tissue polysaccha-rides
164. Structural aspects of skeletal keratan sulphates
165. Endothelial heparan sulfate proteoglycans that bind to L-selectin have glucosamine residues with unsubstituted amino groups
166. Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells
167. Constant and variable domains of different disaccharide structure in corneal keratan sulphate chains
168. Binding of heparin fractions and other polysulfated polysaccharides to plasma fibronectin: effects of molecular size and degree of sulfation of polysaccharides
169. Effects of the treatment with matrix on elderly people with chronic articular degeneration
170. Purification and properties of human platelet heparitinase
171. FGF binding and FGF receptor activation by synthetic heparin-derived di- and ti-saccharides
172. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells
173. Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization
174. Oligosaccha-ride sequences of endothelial cell surface heparan sulfate proteoglycan with affinity for lipoprotein lipase
175. Structure and affinity for antithrombin of heparan sulfate chains derived from basement membrane proteoglycans
176. Structure and antithrombin-binding properties of heparin isolated from the clams Anomalocardia brasilianuand Tivela mactroides
177. The structure of Bacillus subtilispectate lyase in complex with calcium
178. Proteoglycans in health and disease: structure and functions
179. Synthesis of hyaluronate in differentiated teratocarcinoma cells
180. Hyaluronate is synthesized at plasma membranes
181. Kinetic analysis of pectate lyases by high-performance liquid chromatog-raphy
182. Kinetic comparisons of trimer-generating pectate and alginate lyases by reversed-phase ion-pair liquid chromatography
183. Differential depolymerization mechanisms of pectate lyases secreted by Erwinia chrysanthemiEC 16
184. Binding of heparin to basic fibroblast growth factor induces a confor-mational change
185. Conformation of the pentasaccharide corresponding to the binding site of heparin for antithrombin III
186. A force-field study of the conformational characteristics of the iduronate ring
187. The coordinated regulation of heparan sulfate, syndecans and cell behavior
188. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation
189. Crystallization and partial characterization of Staphylococcus aureufhyaluronate lyase
190. Controversial glycosaminoglycan conformations
191. Shapes and interactions of carbohydrate chains
192. Study of structurally defined oligosaccharide substrates of heparin and heparan monosulfate lyases
193. Multiple attack and polarity of action of procine pancreatic α-amylase
194. Enzymic pathways of hyaluronan catabolism
195. Platelet Heparitinase
196. Heparin protects heparin-binding growth factor-I from proteolytic inactivation in vitro
197. Endorthelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation
198. Fermentation of mucin and plant polysaccharides by strains of bacteroides from the human colon
199. Chondroitinase ABC digestion of dermatan sulphate
200. The heparin-binding domain of extracellular su-peroxide dismutase C and formation of variants with reduced heparin affinity
201. Cloning and expression of heparinase I gene from Flavobacterium heparinum
202. Characterization and mapping of heparinase I binding to heparin: identification of a heparin binding sequence
203. Heparinase I from Flavobacterium heparinum. The role of the cystrine residue in catalysis as probed by chemical modification and site-directed mutagenesis
204. Heparinase inhibits neovascularization
205. Subunit structure of chondroitinase ABC from Proteus vulgaris
206. Murine macrophage heparanase: inhibition and comparison with metastatic tumor cells
207. Effects of intracameral injection of chondroitinase ABC in vivo
208. The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions
209. Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues
210. Secondary and tertiary structures involving chondroitin and chondroitin sulphates in solution investigated by rotary shadowing/ electron microscopy and computer simulation
211. Secondary and tertiary structures of hyaluronan in aqueous solution investigated by rotary shadowing/electron microscopy and computer simulation
212. Secondary structure of chondroitin sulphate in dimethyl sulphoxide
213. Isolation and characterization of sulphated oligosaccharides released from bovine corneal keratan sulphate by the action of endo-β-galactosidase
214. Hyaluronic acid: a double-helical structure in the presence of potassium at low pH and found also with the cations ammonium, rubidium and caesium
215. Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans
216. Functional roles and subsite locations of Leu 177, Trp 178 and Asn 182 of Aspergillus awamoriglucoamylase determined by site-directed mutagenesis
217. On the structure of heparitin sulfates
218. The substrate specificity of heparin sulphate lyase and hep-arin from Flavobacterium heparinum
219. Mucopolysaccharidoses and anaesthetic risks
220. Interaction of heparin with human basic fibroblast growth factor: protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan
221. Identification and concerted function of two receptor binding sufaces on basic fibroblast growth factor required for mitogenesis
222. Some novel aerobic heparin-degrading bacterial isolates
223. Studies on the polydispersity and heterogeneity of proteokeratan sulfate from calf and porcine cornea. Hoppe-Seyler'sZ
224. Strucuture of keratan sulphate proteoglycans: core proteins, linkage regions, carbohydrate chains
225. Purification and properties of chondroitinase produced by a bacterium isolated from soil
226. Purification and characterization of hyaluronidase from oral Peptostreptococcusspecies
227. Uronic acid composition of heparins and heparan sulfates
228. Use of DADE hepzyme to eliminate heparin interference in coagulation testing
229. Energetic characterization of the basic fibroblast growth factor-heparin interaction: Identification of the heparin binding domain
230. Structural and immunological studies of keratan sulphates from mature bovine articular cartilage
231. Enzymatic depoly-merization of heparin-related polysaccharides
232. The kinetics of degradation of chondroitin sulphates and hyaluronic acid by chondroitinase from Proteus vulgaris
233. The interaction of glycosaminogly-cans with heparin cofactor 11: structure and activity of a high-affinity dermatan sulfate hexasaccharide
234. Subsite mapping of enzymes. Use of subsite map to simulate complete time course of hydrolysis of a polymeric substrate
235. Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate
236. Distribution of iduronate 2-sulphate residues in heparan sulphate
237. Sequence analysis of heparan sulphate indicates defined location of N-sulphated glucosamine and iduronate 2-ulphate residues proximal to the protein-linkage region
238. Strucutre and affinity of a heparin-derived hexaccharide with high affinity for basic fibroblast growth factor
239. Biological roles of oligosaccharides: all of the theories are correct
240. A stereochemical approach to pyranose ring flexibility: Its implications for the conformation of dermatan sulfate
241. Studies on extracellular proteins from Sraphylococcus aureus. III. Investigations on the heterogeneity of hyaluronate lyase using the method of isoelec-tric focusing
242. Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation
243. Extracellular matrixresident basic fibroblast growth factor: Implication for the control of angiogenesis
244. Non-heparin glycosaminwlycan-derived drugs: A biochemical and pharmacologic perspective
245. Enzymatic degradation of cell wall and related plant polysaccharides
246. Effect of a platelet endoglycosidase on cell surface associated heparan sulphate of human cultured endothelial and glial cells
247. Demonstration of a platelet enzyme degrading heparan sulphate
248. Structural studies on the bacterial lyase-resistant tetrasaccharides derived from the antithrombin III-binding site porcine intestinal hep-arin
249. Purification and properties of bacterial chondroitinases and chondrosulfatases
250. Metabolism of plasma membrane-associated heparan sulphate proteoglycans
251. Purification and characterization of heparinase from Flavobacterium heparinum
252. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
253. New domain motif the structure of pectate lyase C, a secreted plant virulence factor
254. Unusual structural features in the parallel b-helix in pectate lyases
255. Regulation of vertebrate left-right asymmetries by extracellular matrix
256. Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin l
257. Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor
258. Three-dimensional structures of acidic and basic fibroblast growth factors