-
2
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon, E. R., and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell 61, 750-767
-
(1990)
Cell
, vol.61
, pp. 750-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
3
-
-
0027905014
-
Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
-
Shirasawa, S., Furuse, M., Yokoyama, N., and Sasazuli, T. (1993) Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260, 85-88
-
(1993)
Science
, vol.260
, pp. 85-88
-
-
Shirasawa, S.1
Furuse, M.2
Yokoyama, N.3
Sasazuli, T.4
-
4
-
-
0028670126
-
The role of p21ras in receptor tyrosine kinase signalling
-
Pronk, C. J., and Bos, J. L. (1994) The role of p21ras in receptor tyrosine kinase signalling. Biochim Biophys Acta 1198, 131-147
-
(1994)
Biochim Biophys Acta
, vol.1198
, pp. 131-147
-
-
Pronk, C.J.1
Bos, J.L.2
-
5
-
-
0027732538
-
Proteins regulating RUA and its relatives
-
Boguski, M. S., and McCormick, F. (1993) Proteins regulating RUA and its relatives. Nature 366, 643-654
-
(1993)
Nature
, vol.366
, pp. 643-654
-
-
Boguski, M.S.1
McCormick, F.2
-
6
-
-
0027335964
-
The effector interactions of p21ras
-
Marshall, M. S. (1993) The effector interactions of p21ras. Trends Biochem. Sci. 18, 250-254
-
(1993)
Trends Biochem. Sci.
, vol.18
, pp. 250-254
-
-
Marshall, M.S.1
-
7
-
-
0024463212
-
Structure of the Ha-ras oncogene product p21 in the guanine-nueleotide triphosphate conformation
-
Pai, E. F., Kabsch, W., Krengel, U., Holmes, K. C., Juhn, J., and Wittinghofer, A. (1989) Structure of the Ha-ras oncogene product p21 in the guanine-nueleotide triphosphate conformation. Nature 341, 209-214
-
(1989)
Nature
, vol.341
, pp. 209-214
-
-
Pai, E.F.1
Kabsch, W.2
Krengel, U.3
Holmes, K.C.4
Juhn, J.5
Wittinghofer, A.6
-
8
-
-
0027736442
-
RAS function and protein kinase cascades
-
Marcus, S., Wigler, M., Xu, H. P., Ballester, R., Kawamukai, M., and Polverino, A. (1993) RAS function and protein kinase cascades. Ciba Found. Symp. 176, 53-61
-
(1993)
Ciba Found. Symp.
, vol.176
, pp. 53-61
-
-
Marcus, S.1
Wigler, M.2
Xu, H.P.3
Ballester, R.4
Kawamukai, M.5
Polverino, A.6
-
9
-
-
0028043185
-
Inhibition of G1 cyclin activity by the Ras/cAMP pathway in yeast
-
Tokiwa, G., Tyers, M., Volpe, T., and Futcher, B. (1994) Inhibition of G1 cyclin activity by the Ras/cAMP pathway in yeast [see comments]. Nature 371, 342-345
-
(1994)
Nature
, vol.371
, pp. 342-345
-
-
Tokiwa, G.1
Tyers, M.2
Volpe, T.3
Futcher, B.4
-
10
-
-
0027937264
-
Cooperative interaction of S. pombe proteins required for mating and morphogenesis
-
Chang, E. C., Bair, M., Wang, Y., Jung, V., Xu, H., and Wigler, M. H. (1994) Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell 79, 131-141
-
(1994)
Cell
, vol.79
, pp. 131-141
-
-
Chang, E.C.1
Bair, M.2
Wang, Y.3
Jung, V.4
Xu, H.5
Wigler, M.H.6
-
11
-
-
0028985079
-
MAP kinase pathways in yeast: For mating and more
-
Herskowitz, I. (1995) MAP kinase pathways in yeast: for mating and more. Cell 80, 187-197
-
(1995)
Cell
, vol.80
, pp. 187-197
-
-
Herskowitz, I.1
-
12
-
-
0027939978
-
Signal transdurtion and cell fate specification during Caenorhabditis elegans vulval development
-
Eisenmann, D. M., and Kim, S. K. (1994) Signal transdurtion and cell fate specification during Caenorhabditis elegans vulval development. Curr. Opin. Genet. Dev. 4, 508-516
-
(1994)
Curr. Opin. Genet. Dev.
, vol.4
, pp. 508-516
-
-
Eisenmann, D.M.1
Kim, S.K.2
-
13
-
-
0028221043
-
Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila
-
Perrimon, N. (1994) Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila. Curr. Opin. Cell. Biol. 6, 260-266
-
(1994)
Curr. Opin. Cell. Biol.
, vol.6
, pp. 260-266
-
-
Perrimon, N.1
-
14
-
-
0027992319
-
A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases
-
Hsu, J. C., and Perrimon, N. (1994) A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases. Genes Dev. 8, 2176-2187
-
(1994)
Genes Dev.
, vol.8
, pp. 2176-2187
-
-
Hsu, J.C.1
Perrimon, N.2
-
15
-
-
0026679892
-
Raf functions downstream of Ras1 in the Sevenless signal transduction pathway
-
Dickson, B., Sprenger, F., Morrison, D., and Hafen, E. (1992) Raf functions downstream of Ras1 in the Sevenless signal transduction pathway [see comments]. Nature 360, 600-603
-
(1992)
Nature
, vol.360
, pp. 600-603
-
-
Dickson, B.1
Sprenger, F.2
Morrison, D.3
Hafen, E.4
-
16
-
-
0028328631
-
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
-
Brunner, D., Oellers, N., Szabad, J., Biggs, W.E., Zipursky, S. L., and Hafen, E. (1994) A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76, 875-888
-
(1994)
Cell
, vol.76
, pp. 875-888
-
-
Brunner, D.1
Oellers, N.2
Szabad, J.3
Biggs, W.E.4
Zipursky, S.L.5
Hafen, E.6
-
17
-
-
0027930236
-
Drosophila Jun mediates Ras-dependent photoreceptor determination
-
Bohmann, D., Ellis, M. C., Staszewski, L. M., and Mlodzik, M. (1994) Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell 78, 973-986
-
(1994)
Cell
, vol.78
, pp. 973-986
-
-
Bohmann, D.1
Ellis, M.C.2
Staszewski, L.M.3
Mlodzik, M.4
-
18
-
-
0028080794
-
Identification of genes that interact with the sina gene in Drosophila eye development
-
Carthew, R. W., Neufeld, T. P., and Rubin, G. M. (1994) Identification of genes that interact with the sina gene in Drosophila eye development. Proc. Natl. Acad. Sci. USA 91, 11689-11693
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11689-11693
-
-
Carthew, R.W.1
Neufeld, T.P.2
Rubin, G.M.3
-
19
-
-
0028239896
-
The activities of two Eta-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway
-
O'Neill, E. M., Rebay, I., Tjian, R., and Rubin, G. M. (1994) The activities of two Eta-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78, 137-147
-
(1994)
Cell
, vol.78
, pp. 137-147
-
-
O'Neill, E.M.1
Rebay, I.2
Tjian, R.3
Rubin, G.M.4
-
20
-
-
0028175091
-
Raf meets Ras: Completing the framework of a signal transduction pathway
-
Avruch, J., Zhang, X. F., and Kyriakis, J. M. (1994) Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem. Sci. 19, 279-283
-
(1994)
Trends Biochem. Sci.
, vol.19
, pp. 279-283
-
-
Avruch, J.1
Zhang, X.F.2
Kyriakis, J.M.3
-
21
-
-
0027956706
-
Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues
-
Chuang, E., Barnard, D., Hettich, L., Zhang, X., Avruch, J., and Marshall, M. (1994) Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues. Mol. Cell. Biol. 14, 5318-5325
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 5318-5325
-
-
Chuang, E.1
Barnard, D.2
Hettich, L.3
Zhang, X.4
Avruch, J.5
Marshall, M.6
-
22
-
-
0028241533
-
Activation of Raf as a result of recruitment to the plasma membrane
-
Stokoe, D., Macdonald, S. G., Cadwallader, K., Symons, M., and Hancock, J. F. (1994) Activation of Raf as a result of recruitment to the plasma membrane. Science 264, 1163-1467
-
(1994)
Science
, vol.264
, pp. 1163-1467
-
-
Stokoe, D.1
Macdonald, S.G.2
Cadwallader, K.3
Symons, M.4
Hancock, J.F.5
-
23
-
-
0028272507
-
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
-
Leevers, S. J., Paterson, H. F., and Marshall, C. J. (1994) Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369, 411-414
-
(1994)
Nature
, vol.369
, pp. 411-414
-
-
Leevers, S.J.1
Paterson, H.F.2
Marshall, C.J.3
-
24
-
-
0027370827
-
Reconstitution of the Raf-1-MEK-ERK signal transduclion pathway in vitro
-
MacDonald, S. G., Crews, C. M., Wu, L., Driller, J., Clark, R., Erikson, R. L., and McCormick, F. (1993) Reconstitution of the Raf-1-MEK-ERK signal transduclion pathway in vitro. Mol. Cell. Biol. 13, 6615-6620
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 6615-6620
-
-
MacDonald, S.G.1
Crews, C.M.2
Wu, L.3
Driller, J.4
Clark, R.5
Erikson, R.L.6
McCormick, F.7
-
25
-
-
0027337248
-
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
-
Zhang, X. F., Settleman, J., Kyriakis, J. M., Takeuchi-Suzuki, E., Elledge, S. J., Marshall, M. S., Bruder, J. T., Rapp, U. R., and Avruch, J. (1993) Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 364, 308-313
-
(1993)
Nature
, vol.364
, pp. 308-313
-
-
Zhang, X.F.1
Settleman, J.2
Kyriakis, J.M.3
Takeuchi-Suzuki, E.4
Elledge, S.J.5
Marshall, M.S.6
Bruder, J.T.7
Rapp, U.R.8
Avruch, J.9
-
26
-
-
0028032296
-
14-3-3: Modulators of signaling proteins?
-
Morrison, D. (1994) 14-3-3: modulators of signaling proteins? Science 266, 56-57
-
(1994)
Science
, vol.266
, pp. 56-57
-
-
Morrison, D.1
-
27
-
-
0028227245
-
The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex
-
Wartmann, M., and Davis, R. (1994) The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex. J. Biol. Chem. 269, 6695-6701
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 6695-6701
-
-
Wartmann, M.1
Davis, R.2
-
28
-
-
0026647749
-
Raf-1 activates MAP kinaoe-kinase
-
Kyriakis, J. M., App, H., Zhang, X. F., Banerjee, P., Brautigan, D. L., Rapp, U. R., and Avruch, J. (1992) Raf-1 activates MAP kinaoe-kinase. Nature 358, 417-121
-
(1992)
Nature
, vol.358
, pp. 417-1121
-
-
Kyriakis, J.M.1
App, H.2
Zhang, X.F.3
Banerjee, P.4
Brautigan, D.L.5
Rapp, U.R.6
Avruch, J.7
-
29
-
-
0028126506
-
PHAS-I as a link between mitogen-activated protein kinase and translation initiation
-
Lin, T., Kong, X., Haystead, T. A. J., Pause, A., Belsham, C., Sonenberg, N., and Lawrence, J. C. (1994) PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 266, 653-656
-
(1994)
Science
, vol.266
, pp. 653-656
-
-
Lin, T.1
Kong, X.2
Haystead, T.A.J.3
Pause, A.4
Belsham, C.5
Sonenberg, N.6
Lawrence, J.C.7
-
30
-
-
0027297647
-
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
-
Marais, R., Wynne, J., and Treisman, R. (1993) The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73, 381-393
-
(1993)
Cell
, vol.73
, pp. 381-393
-
-
Marais, R.1
Wynne, J.2
Treisman, R.3
-
31
-
-
0028130283
-
Reversion of Ras transformed cells by Els transdominant mutants
-
Wasylyk, C., Maira, S. M., Sobieszczuk, P., and Wasylyk, B. (1994) Reversion of Ras transformed cells by Els transdominant mutants. Oncogene 9, 3665-3673
-
(1994)
Oncogene
, vol.9
, pp. 3665-3673
-
-
Wasylyk, C.1
Maira, S.M.2
Sobieszczuk, P.3
Wasylyk, B.4
-
32
-
-
0028239101
-
Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-aclivated protein kinasw Erk2
-
Kortenjann, M., Thomae, O., and Shaw, P. E. (1994) Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-aclivated protein kinasw Erk2. Mol. Cell. Biol. 14, 4815-4824.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4815-4824
-
-
Kortenjann, M.1
Thomae, O.2
Shaw, P.E.3
-
33
-
-
0028228616
-
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
-
Cowley, S., Paterson, H., Kemp, P., and Marshall, C. J. (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852
-
(1994)
Cell
, vol.77
, pp. 841-852
-
-
Cowley, S.1
Paterson, H.2
Kemp, P.3
Marshall, C.J.4
-
34
-
-
0028141496
-
Transformation of mammalian cells by constitulively active MAP kinase kinase
-
Mansour, S. J., Matten, W. T., Hermann, A. S., Candia, J. M., Rong, S., Fukasawa, K., Vande Woude, C. F., and Ahn, N. C. (1994) Transformation of mammalian cells by constitulively active MAP kinase kinase. Science 265, 966-970
-
(1994)
Science
, vol.265
, pp. 966-970
-
-
Mansour, S.J.1
Matten, W.T.2
Hermann, A.S.3
Candia, J.M.4
Rong, S.5
Fukasawa, K.6
Vande Woude, C.F.7
Ahn, N.C.8
-
35
-
-
0029042689
-
Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation
-
Galaktionov, K., Jessus, C., and Beach, D. (1995) Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev, 9, 1046-1058
-
(1995)
Genes Dev
, vol.9
, pp. 1046-1058
-
-
Galaktionov, K.1
Jessus, C.2
Beach, D.3
-
36
-
-
0027215820
-
A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
-
Lange-Carter, C. A., Pleiman, C. M., Gardner, A. M., Blumer, K. J., and Johnson, G. L. (1993) A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260, 315-319
-
(1993)
Science
, vol.260
, pp. 315-319
-
-
Lange-Carter, C.A.1
Pleiman, C.M.2
Gardner, A.M.3
Blumer, K.J.4
Johnson, G.L.5
-
37
-
-
0028568217
-
Differential activation of ERK and JNK mitogen-activated protein kinoes by Raf-1 and MEKK
-
Minden, A., Lin, A., McMahon, M., Langer-Carter, C., Derijard, B., Davis, R. J., Johnson, G. L., and Karin, M. (1994) Differential activation of ERK and JNK mitogen-activated protein kinoes by Raf-1 and MEKK. Science 266, 1719-1723
-
(1994)
Science
, vol.266
, pp. 1719-1723
-
-
Minden, A.1
Lin, A.2
McMahon, M.3
Langer-Carter, C.4
Derijard, B.5
Davis, R.J.6
Johnson, G.L.7
Karin, M.8
-
38
-
-
0028670788
-
Activation of stress-activated protein kinase by MEKK1 phoaphorylation of its activator SEK1
-
Van, M., Dai, T., Deak, J. C., Kyriakis, J. M., Zon, L. I., Woodgett, J. R., and Templeton, D. J. (1994) Activation of stress-activated protein kinase by MEKK1 phoaphorylation of its activator SEK1. Nature 372, 798-800
-
(1994)
Nature
, vol.372
, pp. 798-800
-
-
Van, M.1
Dai, T.2
Deak, J.C.3
Kyriakis, J.M.4
Zon, L.I.5
Woodgett, J.R.6
Templeton, D.J.7
-
39
-
-
0028558986
-
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
-
Sanchez, I., Hughes, R. T., Mayer, B. J., Yee, K., Woodgett, J. R., Avruch, J., Kyriakis, J. M., and Zon, L. I. (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372, 794-798
-
(1994)
Nature
, vol.372
, pp. 794-798
-
-
Sanchez, I.1
Hughes, R.T.2
Mayer, B.J.3
Yee, K.4
Woodgett, J.R.5
Avruch, J.6
Kyriakis, J.M.7
Zon, L.I.8
-
40
-
-
0028905076
-
Transcription factor ATF2 regulation by the JNK signal transduction pathway
-
Gupta, S., Camphell, D., Derijard, B., and Davis, R. J. (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267, 389-393
-
(1995)
Science
, vol.267
, pp. 389-393
-
-
Gupta, S.1
Camphell, D.2
Derijard, B.3
Davis, R.J.4
-
41
-
-
85087584771
-
Raft-dependent growth factor regulation of MEK kinaae in PC12 cells
-
Lange-Carter, C. A., and Johnson, G. L. (1994) Raft-dependent growth factor regulation of MEK kinaae in PC12 cells. Science 265, 1158-1461
-
(1994)
Science
, vol.265
, pp. 1158-1461
-
-
Lange-Carter, C.A.1
Johnson, G.L.2
-
42
-
-
0027964728
-
Synergistic activation by Ras und 14-3-3 protein of a mitogen-activated protein kinase kinase kinase named Ras-dependent extracellular signal-regulated kinase kinase stimulator
-
Shimizu, K., el al. (1994) Synergistic activation by Ras und 14-3-3 protein of a mitogen-activated protein kinase kinase kinase named Ras-dependent extracellular signal-regulated kinase kinase stimulator. J. Biol Chem 269, 22917-22920
-
(1994)
J. Biol Chem
, vol.269
, pp. 22917-22920
-
-
Shimizu, K.1
-
43
-
-
0025050530
-
Suppression of c-ras transformation by GTPase-activating protein
-
Zhang, K., DeClue, J. E., Vass, W. C., Papageorge, A. C., McCormick, F., and Lowy, U. R. (1990) Suppression of c-ras transformation by GTPase-activating protein. Nature 346, 754-756
-
(1990)
Nature
, vol.346
, pp. 754-756
-
-
Zhang, K.1
DeClue, J.E.2
Vass, W.C.3
Papageorge, A.C.4
McCormick, F.5
Lowy, U.R.6
-
44
-
-
0026567562
-
CAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents
-
Martin, G.A., Yatani, A., Clark, R., Conroy, L., Polakis, P., Brown, A. M., and McCormick, F. (1992) CAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents [see comments]. Science 255, 192-194
-
(1992)
Science
, vol.255
, pp. 192-194
-
-
Martin, G.A.1
Yatani, A.2
Clark, R.3
Conroy, L.4
Polakis, P.5
Brown, A.M.6
McCormick, F.7
-
45
-
-
0026778344
-
GTPase-activating protein in SH2-SH3 domains induce gene expression in a Ras-dependent fashion
-
Medema, R. H., de Laat, W. L., Martin, G. A., McCormick, F., and Bos, J. L. (1992) GTPase-activating protein in SH2-SH3 domains induce gene expression in a Ras-dependent fashion. Mol. Cell. Biol. 12, 3425-3430
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 3425-3430
-
-
Medema, R.H.1
De Laat, W.L.2
Martin, G.A.3
McCormick, F.4
Bos, J.L.5
-
46
-
-
0027452106
-
Functional role of CTPase-activating protein in cell transformation by pp60v-src
-
DeClue, J. E., Vass, W. C., Johnson, M. R., Stacey, D. W., and Lowy, D. R. (1993) Functional role of CTPase-activating protein in cell transformation by pp60v-src. Mol. Cell. Biol. 13, 6799-6809
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 6799-6809
-
-
DeClue, J.E.1
Vass, W.C.2
Johnson, M.R.3
Stacey, D.W.4
Lowy, D.R.5
-
47
-
-
0027339729
-
Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling
-
Duchesne, M., Schweighoffer, F., Parker, F., Clerc, F., Fmbert, Y., Thang, M. N., and Tocque, B. (1993) Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling. Science 259, 525-528
-
(1993)
Science
, vol.259
, pp. 525-528
-
-
Duchesne, M.1
Schweighoffer, F.2
Parker, F.3
Clerc, F.4
Fmbert, Y.5
Thang, M.N.6
Tocque, B.7
-
48
-
-
0028109685
-
Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activuting protein SH3 domain
-
Muttingly, R. R., Sorisky, A., Brann, M. R., and Marara, I. G. (1994) Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activuting protein SH3 domain. Mol. Cell. Biol. 14, 7943-7952
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 7943-7952
-
-
Muttingly, R.R.1
Sorisky, A.2
Brann, M.R.3
Marara, I.G.4
-
49
-
-
0028947757
-
Association of p62, a multifunctional SK2- And SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1
-
Richard, S., Yu, D., Blumer, K. J., Hausladen, D., Olszowy, M. W., Connelly, P. A., and Shaw, A. S. (1995) Association of p62, a multifunctional SK2-and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. Mol. Cell. Biol. 15, 186-197
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 186-197
-
-
Richard, S.1
Yu, D.2
Blumer, K.J.3
Hausladen, D.4
Olszowy, M.W.5
Connelly, P.A.6
Shaw, A.S.7
-
50
-
-
0027988106
-
P190 RhoGAP, the major RasGAP-associated protein, binds GTP directly
-
Foster, R., Hu, K. Shaywitz, D. A., and Settleman J. (1994) p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly. Mol. Cell. Biol. 14, 7173-7181
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 7173-7181
-
-
Foster, R.1
Hu, K.2
Shaywitz, D.A.3
Settleman, J.4
-
51
-
-
0027296039
-
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion
-
McGlade, J., Brunkhorst, B., Anderson D., Mbamalu, G., Settleman, J., Dedhar, S., Rozakis-Adcock, M., Chen, L. B., and Pawson, T. (1993) The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. Embo J. 12, 3073-3081
-
(1993)
Embo J.
, vol.12
, pp. 3073-3081
-
-
McGlade, J.1
Brunkhorst, B.2
Anderson, D.3
Mbamalu, G.4
Settleman, J.5
Dedhar, S.6
Rozakis-Adcock, M.7
Chen, L.B.8
Pawson, T.9
-
52
-
-
0027441940
-
Rho family GTPase activating proteins p 190, ber and rhoGAP show distinct specificities in vitro and in vivo
-
Ridley, A. J., Self, A. J., Kasmi, F., Paterson, H. F., Hall, A., Marshall, C. J., and Ellis, C. (1993) rho family GTPase activating proteins p 190, ber and rhoGAP show distinct specificities in vitro and in vivo. Embo J. 12, 5151-5160
-
(1993)
Embo J.
, vol.12
, pp. 5151-5160
-
-
Ridley, A.J.1
Self, A.J.2
Kasmi, F.3
Paterson, H.F.4
Hall, A.5
Marshall, C.J.6
Ellis, C.7
-
53
-
-
0027337760
-
Complex formation between the p21ras GTPase-activating protein and phosphoproteins p62 and p 190 is independent of p21ras signalling
-
Pronk, G. J., de Vries-Smits, A. M., Ellis, C., and Bos, J. L. (1993) Complex formation between the p21ras GTPase-activating protein and phosphoproteins p62 and p 190 is independent of p21ras signalling. Oncogene 8, 2773-2780
-
(1993)
Oncogene
, vol.8
, pp. 2773-2780
-
-
Pronk, G.J.1
De Vries-Smits, A.M.2
Ellis, C.3
Bos, J.L.4
-
54
-
-
0028108970
-
A novel mammalian Ras GTPase-activating protein which has phospholipid-bindingand Btk homology regions
-
Maekawa, M., Li, S., Iwamatsu, A., Morishila, T., Yokota, K., Imai, Y., Kohsaka, S., Nakamura, A., and Hattori, S. (1994) A novel mammalian Ras GTPase-activating protein which has phospholipid-bindingand Btk homology regions. Mol. Cell. Biol. 14, 6879-6885
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6879-6885
-
-
Maekawa, M.1
Li, S.2
Iwamatsu, A.3
Morishila, T.4
Yokota, K.5
Imai, Y.6
Kohsaka, S.7
Nakamura, A.8
Hattori, S.9
-
55
-
-
0028486018
-
Phoaphatidylinositol 3-kinuse
-
Kapeller, R., and Cantley, L. C. (1994) Phoaphatidylinositol 3-kinuse. BioEssays 16, 565-576
-
(1994)
BioEssays
, vol.16
, pp. 565-576
-
-
Kapeller, R.1
Cantley, L.C.2
-
56
-
-
0028338545
-
Activation of phorsphoinositide 3-kinase activity by Cdc42Hs binding to p85
-
Zheng, V., Bagrodia, S., and Cerione, R. A. (1994) Activation of phorsphoinositide 3-kinase activity by Cdc42Hs binding to p85. J. Biol. Chem. 269, 18727-18730
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 18727-18730
-
-
Zheng, V.1
Bagrodia, S.2
Cerione, R.A.3
-
57
-
-
0027496730
-
ADP-ribosylalion of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinoaitol 3-kinase activation in cultured Swiss 3T3 cells
-
Kumagai, N., Morii, N., Fujisawa, K., Nemoto, Y., and Narumiya, S. (1993) ADP-ribosylalion of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinoaitol 3-kinase activation in cultured Swiss 3T3 cells. J. Biol. Chem. 268, 24535-24538
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 24535-24538
-
-
Kumagai, N.1
Morii, N.2
Fujisawa, K.3
Nemoto, Y.4
Narumiya, S.5
-
58
-
-
12044259376
-
Membrane ruffling and signal transduction
-
Ridley, A. J. (1994) Membrane ruffling and signal transduction. Bioessays 16, 321-327
-
(1994)
Bioessays
, vol.16
, pp. 321-327
-
-
Ridley, A.J.1
-
59
-
-
0028178928
-
PDGF- And insulin-dependent pp70s6k activation mediated by phosphatidylinositol-3-OH kinase
-
Chung, J., Grammer, T. C., Lemon, K. P., Kazlauskas, A., and Blenis, J. (1994) PDGF-and insulin-dependent pp70s6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370, 71-75
-
(1994)
Nature
, vol.370
, pp. 71-75
-
-
Chung, J.1
Grammer, T.C.2
Lemon, K.P.3
Kazlauskas, A.4
Blenis, J.5
-
60
-
-
0027535742
-
Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5 Irisnhosphate
-
Nakanishi, H., Brewer, K. A., and Exton, J. H. (1993) Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5 Irisnhosphate. J. Biol. Chem. 268, 13-16
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 13-16
-
-
Nakanishi, H.1
Brewer, K.A.2
Exton, J.H.3
-
61
-
-
0028918408
-
Ras-dependent induction of cellular responses by constitutively active Phosphatidylinositol-3- Kinase
-
Hu, Q., Klippel, A., Muslin, A. J., Fantl, W. J., and Williams, L. T. (1995) Ras-dependent induction of cellular responses by constitutively active Phosphatidylinositol-3-kinase. Science 268, 100-102
-
(1995)
Science
, vol.268
, pp. 100-102
-
-
Hu, Q.1
Klippel, A.2
Muslin, A.J.3
Fantl, W.J.4
Williams, L.T.5
-
62
-
-
0027053782
-
Agonist-induced association of the p21raft GTPase-activating protein with phosphatidylinositol 3-kinase
-
Sjolander, A., and Lapetina, E. G. (1992) Agonist-induced association of the p21raft GTPase-activating protein with phosphatidylinositol 3-kinase. Biochem. Biophys. Res. Commun. 189, 1503-1508
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.189
, pp. 1503-1508
-
-
Sjolander, A.1
Lapetina, E.G.2
-
63
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana, P., Warne, P. H., Dhand, K., Vunhuesehroeck, B., Gout, I., Fry, M. J., Wuteifield, M. U., and Downward, J. (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370, 527-532
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, K.3
Vunhuesehroeck, B.4
Gout, I.5
Fry, M.J.6
Wuteifield, M.U.7
Downward, J.8
-
64
-
-
0028429961
-
Activation of phosphuinositide 3-kinase is required for PDGF-slimulated membrane ruffling
-
Wennstrom, S., Hawkins, P., Cooke, F., Hara, K., Yonezuwa, K., Kasuga, M., Jackson, T., Claesson-Welsh, L., und Stephens, L. (1994) Activation of phosphuinositide 3-kinase is required for PDGF-slimulated membrane ruffling, Curr. Biol. 4, 385-393
-
(1994)
Curr. Biol.
, vol.4
, pp. 385-393
-
-
Wennstrom, S.1
Hawkins, P.2
Cooke, F.3
Hara, K.4
Yonezuwa, K.5
Kasuga, M.6
Jackson, T.7
Claesson-Welsh, L.8
Stephens, L.9
-
65
-
-
0028903247
-
An essential role for Rac in Ras transformation
-
Qiu, R., Chen, J., Kim, D., McCorrnirk, F., and Symons, M. (1995) An essential role for Rac in Ras transformation. Nature 374, 457-459
-
(1995)
Nature
, vol.374
, pp. 457-459
-
-
Qiu, R.1
Chen, J.2
Kim, D.3
McCorrnirk, F.4
Symons, M.5
-
66
-
-
0001613219
-
Protein kinase C zeta subspecies from rat brain: Its structure, expression, and properties
-
Uno, Y., Fujii, T., Ogita, K., Kikkawa, U., Igarashi, K., and Nishizuka, Y. (1989) Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties, Proc. Natl. Acad. Sci. USA 86, 3099-3103
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 3099-3103
-
-
Uno, Y.1
Fujii, T.2
Ogita, K.3
Kikkawa, U.4
Igarashi, K.5
Nishizuka, Y.6
-
67
-
-
0028310840
-
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinuse C zeta und the vav and c-raf proto-oncogene products
-
Kuzanietz, M. C., et al. (1994} Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinuse C zeta und the vav and c-raf proto-oncogene products. J. Biol. Chem. 269, 11590;11594
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 11590
-
-
Kuzanietz, M.C.1
-
68
-
-
0028176502
-
Zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro
-
Diaz-Meco, M. T., et al. (1994) zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. Embo J. 13, 2842-2848
-
(1994)
Embo J.
, vol.13
, pp. 2842-2848
-
-
Diaz-Meco, M.T.1
-
69
-
-
0028063391
-
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta
-
Diaz-Meco, M. T., Lozano, J., Municio, M. M., Berra, E., Frutos, S., Sanz, L., and Moscat, J. (1994) Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta. J. Biol. Chem. 269, 31706-31710
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 31706-31710
-
-
Diaz-Meco, M.T.1
Lozano, J.2
Municio, M.M.3
Berra, E.4
Frutos, S.5
Sanz, L.6
Moscat, J.7
-
70
-
-
0027200883
-
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
-
Warne, P. H., Vicinna, P. R., and Downward, J. (1993) Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro, Nature 364, 352-355
-
(1993)
Nature
, vol.364
, pp. 352-355
-
-
Warne, P.H.1
Vicinna, P.R.2
Downward, J.3
-
71
-
-
0028153277
-
Activated Ras interacts with the Ral gunnine nucleotide dissociation stimulator
-
Hofer, F., Fields, S., Schneider, C., and Martin, G. S. (1994) Activated Ras interacts with the Ral gunnine nucleotide dissociation stimulator. Proc. Natl. Acad. Sci. USA 91, 11089-11093
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11089-11093
-
-
Hofer, F.1
Fields, S.2
Schneider, C.3
Martin, G.S.4
-
72
-
-
0028859266
-
A human protein selected for interference with Ras function interacts directly with Has and competes with Raf-1
-
Han, L., and Colicelli, J. (1995) A human protein selected for interference with Ras function interacts directly with Has and competes with Raf-1. Mol. Cell. Biol. 15, J318-1323
-
(1995)
Mol. Cell. Biol.
, vol.15
-
-
Han, L.1
Colicelli, J.2
-
73
-
-
0027518574
-
Characterization of a guanine nudeotide dissociation stimulator fora ras-related GTPase
-
Albright, C. F., Giddings, B. W., Liu, J., Vito, M., and Weinberg, R. A. (1993) Characterization of a guanine nudeotide dissociation stimulator fora ras-related GTPase. Embo J. 12, 339-347
-
(1993)
Embo J.
, vol.12
, pp. 339-347
-
-
Albright, C.F.1
Giddings, B.W.2
Liu, J.3
Vito, M.4
Weinberg, R.A.5
-
74
-
-
0027201596
-
Isolation of c-DNA clones and tissue expression of rat ral A and ral B GTP-binding proteins
-
Wildey, G. M., Viggeswarapu, M., Rim, S., and Denker, J. K. (1993) Isolation of c-DNA clones and tissue expression of rat ral A and ral B GTP-binding proteins. Biochem. Biophys. Rev. Commun. 194, 552;559
-
(1993)
Biochem. Biophys. Rev. Commun.
, vol.194
, pp. 552
-
-
Wildey, G.M.1
Viggeswarapu, M.2
Rim, S.3
Denker, J.K.4
-
75
-
-
0027920487
-
Ra1 and Rab3a are major CTP-binding proteins of axonal rapid transport and synaptic vesicles and do not redistribute following depolarization stimulated synaplosomal exocylosia
-
Bielinski, D. F., Pyun, H. Y., Linko-Stentz, K., Macara, I. G., and Fine, R. E. (1993) Ra1 and Rab3a are major CTP-binding proteins of axonal rapid transport and synaptic vesicles and do not redistribute following depolarization stimulated synaplosomal exocylosia. Biochim. Biophys. Acta 1151, 246-256
-
(1993)
Biochim. Biophys. Acta
, vol.1151
, pp. 246-256
-
-
Bielinski, D.F.1
Pyun, H.Y.2
Linko-Stentz, K.3
Macara, I.G.4
Fine, R.E.5
-
76
-
-
0028223704
-
Dissociation between activation of Raf-1 kinase and the42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells
-
Porras, A., Muszynski, K., Rapp, U. R., and Santos, E. (1994) Dissociation between activation of Raf-1 kinase and the42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells. J. Biol. Chem. 269, 12741-12748
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 12741-12748
-
-
Porras, A.1
Muszynski, K.2
Rapp, U.R.3
Santos, E.4
-
77
-
-
0028840086
-
Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the raf-dependent cytoplasmic kinase cascade
-
Al-Alawi, N., Rose, D. W., Buckmaster, C., Ahn, IV., Rapp, U., Meinkoth, J., and Feramisco, J. R. (1995) Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the raf-dependent cytoplasmic kinase cascade. Mol. Cell. Biol. 15, 1162-1168
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1162-1168
-
-
Al-Alawi, N.1
Rose, D.W.2
Buckmaster, C.3
Ahn, I.V.4
Rapp, U.5
Meinkoth, J.6
Feramisco, J.R.7
-
78
-
-
0028948382
-
Multiple Ras functions can contribute to mammalian cell transformation
-
White, M. A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M., and Wigler, M. H. (1995) Multiple Ras functions can contribute to mammalian cell transformation. Cell 80, 533-541
-
(1995)
Cell
, vol.80
, pp. 533-541
-
-
White, M.A.1
Nicolette, C.2
Minden, A.3
Polverino, A.4
Van Aelst, L.5
Karin, M.6
Wigler, M.H.7
|