Receptor occupation and pharmacokinetics of MPC-1304, a new Ca2+ channel antagonist, in spontaneously hypertensive rats

European Journal of Pharmacology

Volumn 287, Issue 2, 1995, Pages 191-196

  Nozawa, Yoshihisa ^a   Miyake, Hidekazu ^a   Yamada, Shizuo ^b   Uchida, Shinya ^b   Ohkura, Takashi ^b   Kimura, Ryohei ^b  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Ca2+ channel antagonist receptor; MPC 1304; Receptor occupation; Spontaneously hypertensive rat (SHR)

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; ARANIDIPINE; CALCIUM ANTAGONIST; CALCIUM CHANNEL; ISRADIPINE; NEW DRUG; NIFEDIPINE; RADIOLIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HEART MUSCLE; HYPERTENSION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIORECEPTOR ASSAY; RAT; RECEPTOR DENSITY; RECEPTOR OCCUPANCY; SPONTANEOUSLY HYPERTENSIVE RAT; TISSUE SPECIFICITY;

ADMINISTRATION, ORAL; ANIMAL; AORTA; BINDING, COMPETITIVE; CALCIUM CHANNEL BLOCKERS; CEREBRAL CORTEX; DIHYDROPYRIDINES; HEART; HYPERTENSION; MALE; NIFEDIPINE; RATS; RATS, INBRED SHR; TIME FACTORS;

EID: 0028825417     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00651-6     Document Type: Article

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