Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A

Journal of Clinical Investigation

Volumn 96, Issue 4, 1995, Pages 1698-1705

  Schinkel, Alfred H ^a   Wagenaar, Els ^a   Van Deemter, Liesbeth ^a   Mol, Carla A A M ^a   Borst, Piet ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

blood brain barrier; morphine; multidrug resistance; neurotoxicity; reversal agents

Indexed keywords

CYCLOSPORIN A; DEXAMETHASONE; DIGOXIN; GLYCOPROTEIN P; IVERMECTIN; MORPHINE; VINBLASTINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG TRANSPORT; EPITHELIUM CELL; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY EPITHELIUM; MALE; MOUSE; MULTIDRUG RESISTANCE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

EID: 0028825399     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118214     Document Type: Article

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