Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Hydrochloride and Related Compounds

Journal of Medicinal Chemistry

Volumn 38, Issue 24, 1995, Pages 4821-4829

  Sugimoto, Hachiro ^a   Iimura, Youichi ^a   Yamanishi, Yoshiharu ^a   Yamatsu, Kiyomi ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 4 [2 (2 ISOINDOLINYL)ETHYL]PIPERIDINE; 4 (2 BENZAMIDOETHYL) 1 BENZYLPIPERIDINE; ACETYLCHOLINE; CHOLINESTERASE INHIBITOR; DONEPEZIL; PHYSOSTIGMINE; TACRINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BINDING SITE; DRUG POTENCY; DRUG SPECIFICITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMAL; BINDING SITES; BRAIN; CHOLINESTERASE INHIBITORS; COMPARATIVE STUDY; INDANS; MALE; MICE; PIPERIDINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0028823072     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00024a009     Document Type: Article

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