Interaction of heavy metal toxicants with brain constitutive nitric oxide synthase

Molecular and Cellular Biochemistry

Volumn 149-150, Issue 1, 1995, Pages 263-265

  Mittal, Chandra K ^a   Harrell, William B ^a   Mehta, Chander S ^a  

^a TEXAS SOUTHERN UNIVERSITY   (United States)

Author keywords

calcium; NO synthase; signal transduction; toxic metals

Indexed keywords

CALCIUM; HEAVY METAL; NITRIC OXIDE SYNTHASE;

BRAIN; CONFERENCE PAPER; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

ANIMAL; BRAIN; CATIONS; CYTOSOL; METALS; NITRIC-OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028822678     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/BF01076586     Document Type: Article

References (12)

1. Nitric oxide as a secretory product of mammalian cells
2. Nitric oxide synthase and neuronal diaphorase are identical in brain and peripheral tissues
3. Ca2+/calmodulin-dependent cytochrome C reductase activity of brain nitric oxide synthase
4. Nitric oxide synthase is a cytochrome P-450 type hemoprotein
5. Reduced biopterine as a cofactor in the generation of nitrogen oxides by murine macrophages
6. Nitric oxide synthase: Involvement of oxygen radicals in conversion of L-arginine to nitric oxide
7. Calcium-dependent inhibition of constitutive nitric oxide synthase
8. Purification and characterization of particulate endothelium derived relaxing factor synthase from cultured and native bovine aortic endothelial cells
9. Oxidation of NG-hydroxy-L-arginine by nitric oxide synthase: Evidence for the involvement of the heme in catalysis
10. Inhibition of nitric oxide synthase activity in rat brain by metals
11. Differential modulatory effects of heavy metal toxicants on constitutive nitric oxide synthase
12. Evidence that peroxidation of Iysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity