Phenotype and frequency of cells secreting il-2, il-4, il-6, il-10, ifn and tnf-α in human peripheral blood

Cytokine

Volumn 7, Issue 8, 1995, Pages 815-822

  Hagiwara, Eri ^a   Abbasi, Fatima ^b   Mor, Gil ^a   Ishigatsubo, Yoshiaki ^c   Klinman, Dennis M ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Cytokine; Human; Lymphocyte; Monocyte; Peripheral blood

Indexed keywords

EID: 0028822532     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1995.0098     Document Type: Article

References (54)

1. Paul WE (1989) Pleiotropy and redundancy: T cell-derived lymphokines in the immune response. Cell 57:521-524.
2. Balkwill FR, Burke F (1989) The cytokine network. Immunol Today 10:299-304.
3. Mosmann TR, Coffman RL (1987) Two types of mouse helper T-cell clone. Immunol Today 8:223-227.
4. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136:2348-2357.
5. Fiorentino DF, Bond MW, Mosmann TR (1989) Two types of mouse T helper cell. IV: TH2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 170:2081-2095.
6. Romagnami S (1992) Induction of Th1 and T2 responses: a key role for the ʼnatural’ immune response? Immunol Today 13:379-381.
7. Paliard X, De Waal Malefijt R, Yssel H, Blanchard D, Chretien I, Abrams J et al. (1988) Simultaneous production of IL-2, IL-4 and IFN-gamma by activated human CD4+ and CD8+ T cell clones. J Immunol 3:849-855.
8. Maggi E, Del Prete G, Macchia D, Parronchi P, Tiri A, Chretien I et al. (1988) Profiles of lymphokine activities and helper function for IgE in human T cell clones. Eur J Immunol 18:1045-1050.
9. Heinzel FP, Sadick MD, Mutha SS, Locksley RM (1991) Production of IFN gamma, IL-2, IL-4 and IL10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci 88:7011-7015.
10. Pearce EJ, Caspar P Grzych JM, Lewis FA, Sher A (1991) Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J Exp Med 173:159-168.
11. Del Prete G, De Carli M, Mastromauro C, Biagotti R, Macchia D, Falagiani P et al. (1991) Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 88:346-350.
12. Modlin R, Nutman T (1993) Type 2 cytokines and negative immune regulation in human infections. Cur Op Immunol 5:511-517.
13. Sawada T, Hirohata S, Inoue T, Ito K (1991) Correlation between rheumatoid factor and IL-6 activity in synovial fluids from patients with rheumatoid arthritis. Clin and Exp Rheum 9:363-368.
14. Chen E, Keystone E, Fish E (1993) Restricted cytokine expression in rheumatoid arthritis. Arthritis Rheum 36:901-910.
15. Miossec P Naviliat M, Dupuy D, Angeac A, Sany J, Banchereau J (1990) Low Levels of interleukin-4 and high levels of TGF-b in rheumatoid arthritis. Arthritis Rheum 33:1180.
16. Katsikis P, Chu C, Brennan F, Maini R, Feldmann M (1994) Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med 179:1517-1527.
17. Lathey J, Kanangat S, Rouse B (1994) Differential expression of tumor necrosis factor alpha and interleukin 1 beta compared with interleukin 6 in monocytes from human immunodeficiency virus-positive individuals measured by polymerase chain reaction. JAIDS 7:109-115.
18. Maggi E, Mazzetti M, Ravina A, Annunziato F, De Carli M, Piccinni M, Manetti R, Cabonari M, Pesce A, Del Prete G, Romagnani S (1994) Ability of HIV to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science 265:244-248.
19. Graziosi C, Pantaleo G, Gantt K, Fortin J, Demarest J, Cohen O, Sekaly R, Fauci A (1994) Lack of evidence for the dichotomy of Th1 and Th2 predominance in HIV-infected individuals. Science 265:248-252.
20. Al-Janadi M, Al-Balla S, Al-Dalaan A, Raziuddin S (1993) Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis and other rheumatic diseases. J Clin Immunol 13:58-67.
21. Marchant A, Deviere J, Byl B, De Groote D, Vincent J, Goldman M (1994) Interleukin-10 production during septicaemia. Lancet 343:707-708.
22. Oliver JC, Bland LA, Oettigner CW, Arduino MJ, McAllister SK (1993) Cytokine kinetics in an in vitro whole blood model following an endotoxin challenge. Lymph Cyto Res 12:115-120.
23. Waage A, Brandtzaeg P Halstensen A, Kierulf P Espevik T (1989) The complex pattern of cytokines in serum from patients with meningococcal septic shock. J Exp Med 169:333-338.
24. Shirai A, Holmes K, Klinman DM (1993) Detection and quantitation of cells secreting IL-6 under physiological conditions in BALB/c mice. J Immunol 150:793-799.
25. Bendtzen K, Svenson M, Jonsson V, Hippe E (1990) Autoantibodies to cytokines-friends or foes? Immunol Today 5:167-169.
26. Lagoo A, Lagoo-Deenadayalan S, Lorenz H, Byrne J, Barber W, Hardy K (1994) IL-2, IL-4, and IFN-gamma gene expression versus secretion in superantigen-activated T cells. J Immunol 152:1641-1652.
27. Ehlers S, Smith K (1991) Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J Exp Med 173:25-36.
28. Lewis D, Yu C, Meyer J, English B, Kahn S, Wilson C (1991) Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma by neonatal cells. J Clin Invest 87:194-202.
29. Skansen-Saphir U, Andersson J, Bjork L, Andersson U (1994) Lymphokine production induced by streptococcal pyrogenic exotoxin-A is selectively down-regulated by pooled human IgG. Eur J Immunol 24:916-922.
30. Andersson U, Andersson J, Lindfors A, Wagner K, Moller G, Heusser C (1990) Simultaneous production of interleukin 2, interleukin 4 and interferon gamma by activated human blood lymphocytes. Eur J Immunol 20:1591-1596.
31. Andersson U, Matsuda T (1989) Human interleukin 6 and tumor necrosis factor alpha production studied at a single-cell level. Eur J Immunol 19:1157-1160.
32. Mueller R, Heusser CH, Rihs S, Brunner T, Bullock GR, Dahinden CA (1994) Immunolocalization of intracellular IL-4 in normal human peripheral blood basophils. Eur J Immunol 24:2935-2940.
33. Sander B, Andersson J, Andersson U (1991) Assessment of cytokines by immunofluorescence and the paraformaldehydesaponin procedure. Immunol Rev 119:65-93.
34. Jung T, Schauer U, Heusser C, Neumann C, Rieger C (1993) Detection of intracellular cytokines by flow cytometry. J Immunol Methods 159:197-207.
35. Fernandez V, Andersson J, Andersson U, Troye M (1994) Cytokine synthesis analyzed at the single-cell level before and after revaccination with tetanus toxoid. Eur J Immunol 24:1808-1815.
36. Klinman DM, Nutman TB (1994) ELIspot assay to detect cytokine-secreting murine and human cells. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds) Current Protocols in Immunology. Brooklyn, NY: Greene Publishing Associates.
37. King CL, Low DD, Nutman TB (1993) IgE production in human helminth infection. Reciprocal interrelationship between IL-4 and IFN-gamma. J Immunol 150:1873-1880.
38. El Ghazali G, Paulie S, Andersson G, Hansson Y, Holmquist G, Sun J et al. (1993) Number of interleukin-4 and interferon-gamma secreting human T cells reactive with tetanus toxoid and the mycobacterial antigen PPD or phytohemagglutinin: distinct response profiles depending on the type of antigen used for activation. Eur J Immunol 23:2740-2745.
39. Hutchings PR, Cambridge G, Tite JP, Meager T, Cooke A (1989) The detection and enumeration of cytokine-secreting cells in mice and man and the clinical application of these assays. J Immunol Methods 120:1-8.
40. Versteegen JMT, Logtenberg T, Ballieux RE (1988) Enumeration of IFN-gamma producing human lymphocytes by spot-ELISA. J Immunol Methods 111:25-29.
41. Brinkmann V, Geiger T, Alkan S, Heusser CH (1993) Interferon alpha increases the frequency of interferon gamma producing human CD4+ cells. J Exp Med 1778:1655-1663.
42. Mahanty S, Abrams JS, King CL, Limaye AP, Nutman TB (1992) Parallel regulation of IL-4 and IL-5 in human helminth infections. J Immunol 148:3567-3571.
43. Mahanty S, King CL, Kumaraswami V, Regunathan J, Maya A, Jayaraman K, Abrams JS, Ottensen EA, Nutman TB (1993) IL-4 and IL-5 secreting lymphocyte populations are preferentially stimulated by parasite-derived antigens in human tissue invasive nematode infections. J Immunol 151:3704-3711.
44. Lewis C (1991) Detecting cytokine production at the single-cell level. Cytokine 3:184-188.
45. Maggi E, Biswas P Del Prete G, Parronchi P Maachia D, Simonelli C, Emmi L, De Carli M, Tiri A, Ricci M, Romagnani S (1991) Accumulation of Th2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. J Immunol 1464:1169-1174.
46. Wierenga E, Snoek M, De Groot C, Chretien I, Bos J, Jansen H et al. (1990) Evidence for compartmentalization of functional subsets of CD4+ T lymphocytes in atopic patients. J Immunol 144:4651-4656.
47. Tendler CL, Greenberg SJ, Burton JD, Danielpour D, Kim S, Blattner WA, Manns A, Waldmann TA (1991) Cytokine induction in HTLV-1 associated myelopathy and adult T-cell leukemia: alternative molecular mechanisms underlying retroviral pathogenesis. J Cell Biochem 46:302-311.
48. Shirai A, Sierra V, Kelly CI, Klinman DM (1994) Individual cells simultaneously produce both IL-4 and IL-6 under physiologic conditions in vivo. Cytokine 6:329-336.
49. Conrad DH, Ben-Sasson SZ, Gros GL, Finkelman FD, Paul WE (1990) Infection with Nippostrongylus Brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor mediated IL-4 production by non-B, non-T cells. J Exp Med 171:1497-1598.
50. Van Snick J (1990) IL-6: An overview. Annu Rev Immunol 8:253-278.
51. de Waal Malefyt R, Abrams J, Bennett B, Figdor C, de Vries J (1991) Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL10 produced by monocytes. J Exp Med 174:1209-1220.
52. Schmitz J, Assenmacher M, Radbruch A (1993) Regulation of T helper cell cytokine expression: functional dichotomy of antigen-presenting cells. Eur J Immunol 23:191-199.
53. Boyum A (1968) Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 21:77-90.
54. Semple J, Allen D, Chang W, Castaldi P, Freedman J (1993) Rapid separation of CD4+ and CD19+ lymphocyte populations from human peripheral blood by a magnetic activated cell sorter (MACS). Cytometry 14:955-960.