Mutant U5A cells are complemented by an interferon-αβ receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster

EMBO Journal

Volumn 14, Issue 20, 1995, Pages 5100-5108

  Lutfalla, G ^a   Holland, S J ^a,e   Cinato, E ^a   Monneron, D ^a   Reboul, J ^a   Rogers, N C ^b   Smith, J M ^b   Stark, G R ^c   Gardiner, K ^d   Mogensen, K E ^a   Kerr, I M ^b   Uze G ^a  

^a CNRS   (France)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF DENVER   (United States)

^e MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Cytokine receptor; Gene cluster; Human chromosome 21; Mutant complementation; Splice variants

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE RECEPTOR; INTERFERON; INTERFERON RECEPTOR; MEMBRANE PROTEIN; RECEPTOR SUBUNIT;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL MUTANT; CHROMOSOME 21; CONTROLLED STUDY; DNA STRUCTURE; EXON; GENE CLUSTER; GENE EXPRESSION; GENE MAPPING; GENE STRUCTURE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; POLYADENYLATION; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0028820423     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1995.tb00192.x     Document Type: Article

References (46)

1. Ackerman,S.L., Minden,A.G. and Yeung,C.-Y. (1993) The minimal self-sufficient element in a murine G+C rich promoter is a large element with imperfect dyad symmetry. Proc. Natl. Acad. Sci. USA, 90, 11865-11869.
2. Aguet,M., Dembic,Z. and Merlin,G. (1988) Molecular cloning and expression of the human interferon-γ receptor. Cell, 55, 273-280.
3. Alcaide-Loridan,C., Le Coniat,M., Bono,R., Benech,P., Couillin,P., Van Cong,N., Fisher,D.N., Berger,R. and Fellous,M. (1989) Mapping of the human interferon gamma response. Cytogenet. Cell Genet., 51, 949-960.
4. Allen,G., Fantes,K.H., Burke,D.C. and Morser,J. (1982) Analysis and purification of human lymphoblastoid (Namalwa) interferon using a monoclonal antibody. J. Gen. Virol., 63, 207-212.
5. Bazan,J.E. (1990) Structural design and molecular evolution of acytokine receptor superfamily. Proc. Natl Acad. Sci. USA, 87, 6934-6938.
6. Brownstein,B., Silverman,G., Little,R., Burke,D., Korsmeyer,S., Schlessinger,D. and Olson,M.V. (1989) Isolation of single copy human genes from a library of yeast artificial chromosome clones. Science, 244, 1348-1351.
7. Chumakov,I. et al. (1992) Continuum of overlapping clones spanning the entire human chromosome 21q. Nature, 359, 380-387.
8. Colamonici,O.R. and Domanski,P. (1993) Identification of a novel subunit of the type I interferon receptor localized to chromosome 21. J. Biol. Chem., 268, 10895-10899.
9. Cosman,D. (1993) The hematopoietin receptor superfamily. Cytokine, 5, 95-106.
10. Darnell,J.E.,Jr, Kerr,I.M. and Stark,G.R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science, 264, 1415-1421.
11. Dong,F., van Paasen,M., van Buitenen,C., Hoefsloot,L.H., Löwenberg,B. and Touw,I.P. (1995) A point mutation in the granulocyte colony-stimulating factor receptor (G-CSF-R) gene in a case of acute myeloid leukemia results in the overexpression of a novel G-CSF-R isoform. Blood, 85, 902-911.
12. Gardiner, K., Horrisberger,M., Krauss,J., Tantravahi,U., Korenberg,J., Rao,V., Reddy,S. and Patterson,D. (1990) Analysis of human chromosome 21: correlation of physical map and cytogenetic maps; gene and CpG island distributions. EMBO J., 9, 25-34.
13. Gnirke,A., Barnes,T.S., Patterson,D., Schild,D., Featherstone,T. and Olson,M.V. (1991) Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes. EMBO J., 10, 1629-1634.
14. Hemmi,S., Böhni,R., Stark,G., Di Marco,F. and Aguet,M. (1994) A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Cell, 76, 803-810.
15. Ihle,J.N. and Kerr,I.M. (1995) Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet., 11, 69-74.
16. Kremer,E. et al. (1993) A cytokine receptor gene cluster in the X-Y pseudoautosomal region? Blood, 82, 22-28.
17. Lemesle-Varlot,L., Henrissat,B., Gaboriaud,C., Bissery,V., Morgat,A. and Mornon,J. (1990) Hydrophobic cluster analysis: procedures to derive structural and functional information from 2-D-representation of protein sequences. Biochimie, 72, 555-574.
18. Leung,S., Qureshi,S.A., Kerr,I.M., Darnell,J.E. and Stark,G.R. (1995) Role of STAT2 in the interferon α/β signaling pathway. Mol. Cell. Biol., 15, 1312-1317.
19. Lutfalla,G., Gardiner,K., Proudhon,D., Vielh,E. and Uzé,G. (1992) The structure of the human interferon alpha/beta receptor gene. J. Biol. Chem., 267, 2802-2809.
20. Lutfalla,G., Gardiner,K. and Uzé,G. (1993) A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. Genomics, 16, 366-373.
21. Lutfalla,G.,McInnis,M.G., Antonarakis,S.E. and Uzé,G. (1995) Structure of the human CRFB4 gene: comparison with its IFNAR neighbour. J. Mol. Evol., 41, 333-344.
22. Marck,C. (1988) 'DNA strider': a 'C' program for the fast analysis of DNA and protein sequences on the Apple Macintosh family of computers. Nucleic Acids Res., 16, 1829-1836.
23. Mogensen,K.E. and Uze,G. (1986) Radio iodination of human alpha interferons by the chloramine T method. Methods Enzymol., 119, 267-276.
24. Müller,M., Laxton,C., Briscoe,J., Schindler,C., Improta,T., Darnell, J.E.,Jr, Stark,G.R. and Kerr,J.M. (1993a) Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J., 12, 4221-4228.
25. Müller,M. et al. (1993b) The protein tyrosine kinase JAK1 complements defects in Interferon alpha:beta and gamma signal transduction. Nature, 366, 129-135.
26. Murakami,M., Narazaki,M., Hibi,M., Yawata,H., Yasukawa,K., Hamaguchi,M., Taga,T. and Kishimoto,T. (1991) Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc. Natl Acad. Sci. USA, 88, 11349-11353.
27. Nakagawa,Y., Kosugi,H., Miyajima,A., Arai,K. and Yokota,T. (1994) Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. J. Biol. Chem., 269, 10905-10912.
28. Nakamura,Y. and Nakauchi,H. (1994) A truncated erythropoietin receptor and cell death: a reanalysis. Science, 264, 588-589.
29. Novick,D., Cohen,B. and Rubinstein,M. (1994) The human interferon alpha/beta receptor: characterization and molecular cloning. Cell, 77, 391-400.
30. Pellegrini,S., John,J., Shearer,M., Kerr,J.M. and Stark,G.R. (1989) Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol. Cell. Biol., 9, 4605-4612.
31. Sambrook,J., Fritsch,E.F. and Maniatis,T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
32. Schindler,C., Shuai,K., Prezioso,V.R. and Darnell,J.E. (1992) Interferondependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science, 257, 809-813.
33. Shapiro,M.B. and Senapathy,P. (1987) RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res., 15, 7155-7174.
34. Shirota,M., Banville,D., Ali,S., Jolicoeur,C., Boutin,J.-M., Edery,M., Djiane,J. and Kelly,P.A. (1990) Expression of two forms of prolactin receptor in rat ovary and liver. Mol. Endocrinol., 4, 1136-1143.
35. Soeda,E. et al. (1995) Cosmid assembly and anchoring to human chromosome 21. Genomics, 25, 73-84.
36. Soh,J. et al. (1994a) Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell, 76, 793-802.
37. Soh,J., Mariano,T.M., Lim,J.K., Izotova,L., Mirochnitchenko,O., Schwartz,B., Langer,J.A. and Pestka,S. (1994b) Expression of a functional type I interferon receptor in hamster cells: application of functional YAC screening. J. Biol. Chem., 269, 18102-18110.
38. Streuli,M., Hall,A., Boll,W., Stewart,W.E.,II, Nagata,S. and Weissmann,C. (1981) Target cell specificity of two species of human interferon alpha produced in E.coli and of hybrid molecules derived from them. Proc. Natl Acad. Sci. USA, 78, 2848-2852.
39. Tanner,J.W., Chen,W., Young,R.L., Longmore,G.D. and Shaw,A.S. (1995) The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J. Biol. Chem., 270, 6523-6530.
40. Thoreau,E., Petridou,B., Kelly,P.A., Djiane,J. and Mornon,J.-P. (1991) Structural symmetry of the extracellular domain of the cytokine/ growth hormone/prolactin receptor family and interferon receptors revealed by hydrophobic cluster analysis. FEBS Lett., 282, 16-31.
41. Uzé,G., Lutfalla,G. and Gresser,I. (1990) Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell, 60, 225-234.
42. Uzé,G., Lutfalla,G., Bandu,M.-T., Proudhon,D. and Mogensen,K.E. (1992) Behavior of a cloned murine interferon alpha beta receptor expressed in homospecific or heterospecific background. Proc Natl Acad. Sci. USA, 89, 4774-4778.
43. Uzé,G., Di Marco,S., Mouchei-Vielh,E., Monneron,D., Bandu,M.-T., Horisberger,M.A., Dorques,A., Lutfalla,G. and Mogensen,K.E. (1994) Domains of interaction between alpha interferon and its receptor components. J. Mol. Biol., 243, 245-257.
44. Uze,G., Lutfalla,G. and Mogensen,K.E. (1995) Alpha and beta interferons and their receptor and their friends and relations. J. Interferon Cytokine Res., 15, 3-26.
45. Velazquez,L., Mogensen,K.E., Barbieri,G., Fellous,M., Uzé,G. and Pellegrini,S. (1995) Distinct domains of the tyrosine kinase tyk2 required for high affinity binding of α/β IFNs and for signal transduction. J. Biol. Chem., 270, 3327-3334.
46. Wickens,M. and Stephenson,P. (1984) Role of the conserved AAUAAA sequence: four AAUAAA point mutants prevent messenger RNA 3′ end formation. Science, 226, 1045-1051.