Constitutive episomal expression of polypeptide IX (pIX) in a 293-based cell line complements the deficiency of pIX mutant adenovirus type 5

Journal of Virology

Volumn 69, Issue 11, 1995, Pages 6627-6633

  Caravokyri, Calliope ^a   Leppard, Keith N ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; POLYPEPTIDE;

ADENOVIRUS; ARTICLE; EPISOME; EPSTEIN BARR VIRUS; GENE THERAPY; HUMAN; HUMAN CELL; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPLICON; THERMOSTABILITY; VIRION; VIRUS CAPSID;

EID: 0028820082     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.69.11.6627-6633.1995     Document Type: Article

References (37)

1. Bett, A. J., L. Prevec, and F. L. Graham. 1993. Packaging capacity and stability of human adenovirus type 5 vectors. J. Virol. 67:5911-5921.
2. Bridge, E., and G. Ketner. 1989. Redundant control of adenovirus late gene expression by early region 4. J. Virol. 63:631-638.
3. Caravokyri, C., C. R. Pringle, and K. N. Leppard. 1993. Human adenovirus type 5 recombinants expressing simian immunodeficiency virus macaque strain gag antigens. J. Gen. Virol. 74:2819-2824.
4. Colby, W. W., and T. Shenk. 1981. Adenovirus type 5 virions can be assembled in vivo in the absence of detectable polypeptide IX. J. Virol. 39:977-980.
5. Furcinitti, P. S., J. van Oostrum, and R. M. Burnett. 1989. Adenovirus polypeptide IX revealed as a capsid cement by difference images from electron microscopy and crystallography. EMBO J. 8:3563-3570.
6. Ghosh-Choudhury, G., Y. Haj-Ahmad, and F. L. Graham. 1987. Protein IX, a minor component of the human adenovirus type 5 capsid, is essential for the packaging of full length genomes. EMBO J. 6:1733-1739.
7. Ginsberg, H. S., U. Lundholm-Beauchamp, R. L. Horstwood, B. Pernis, W. S. M. Wold, R. M. Chanock, and G. A. Prince. 1989. Role of early region 3 (E3) in pathogenesis of adenovirus disease. Proc. Natl. Acad. Sci. USA 86: 3823-3827.
8. Gorman, C. H., D. Gies, G. McCray, and M. Huang. 1989. The human cytomegalovirus major immediate early promoter can be trans-activated by adenovirus early proteins. Virology 171:377-385.
9. Graham, F. L., J. Smiley, W. C. Russell, and R. Nairn. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59-72.
10. Haj-Ahmad, Y., and F. L. Graham. 1986. Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene. J. Virol. 57:267-274.
11. Hay, R. T. 1985. The origin of adenovirus DNA replication: minimal DNA sequence requirement in vivo. EMBO J. 4:421-426.
12. Hearing, P., R. J. Samulski, W. L. Wishart, and T. Shenk. 1987. Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome. J. Virol. 61:2555-2558.
13. Hearing, P., and T. Shenk. 1983. The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element. Cell 33:695-703.
14. Horwitz, M. S. 1990. Adenoviridae and their replication, p. 1679-1721. In B. N. Fields et al. (ed.), Virology, 2nd ed., vol. 2. Raven Press, New York.
15. Huang, M.-M., and P. Hearing. 1989. Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection. J. Virol. 63:2605-2615.
16. Jones, N. C., and T. Shenk. 1979. Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells. Cell 17: 683-689.
17. Koenig, M., E. P. Hoffman, C. J. Bertelson, A. P. Monaco, C. Feener, and L. M. Kunkel. 1987. Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals. Cell 50:509-517.
18. Leppard, K. N. Unpublished data.
19. Leppard, K. N., and T. Shenk. 1989. The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism. EMBO J. 8:2329-2336.
20. Liu, G.-Q., L. E. Babiss, F. C. Volkert, C. S. H. Young, and H. S. Ginsberg. 1985. A thermolabile mutant of adenovirus 5 resulting from a substitution mutation in the protein VIII gene. J. Virol. 53:920-925.
21. Margolskee, R. F., P. Kavathas, and P. Berg. 1988. Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells. Mol. Cell. Biol. 8:2837-2847.
22. Melton, D. A., P. A. Krieg, M. R. Rebagliati, T. Maniatis, K. Zinn, and M. R. Green. 1984. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12:7035-7056.
23. Peden, K. W. C., J. M. Pipas, S. Pearson-White, and D. Nathans. 1980. Isolation of mutants of an animal virus in bacteria. Science 209:1392-1396.
24. Philipson, L. 1984. Adenovirus assembly, p. 309-337. In H. S. Ginsberg (ed.), The adenoviruses. Plenum Press, New York.
25. Reich, N. C., P. Sarnow, E. Duprey, and A. J. Levine. 1983. Monoclonal antibodies which recognise native and denatured forms of the adenovirus DNA-binding protein. Virology 128:480-484.
26. Reisman, D., and B. Sugden. 1986. trans-activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1. Mol. Cell. Biol. 6:3838-3846.
27. Sarnow, P., C. A. Sullivan, and A. J. Levine. 1982. A monoclonal antibody detecting the adenovirus type 5 E1b 58Kd tumor antigen: characterization of the E1b 58Kd tumor antigen in adenovirus-infected and -transformed cells. Virology 120:510-517.
28. Stewart, P. L., R. M. Burnett, M. Cyrklaff, and S. D. Fuller. 1991. Image reconstruction reveals the complex molecular organization of adenovirus. Cell 67:145-154.
29. Stewart, P. L., S. D. Fuller, and R. M. Burnett. 1993. Difference imaging of adenovirus: bridging the resolution gap between X-ray crystallography and electron microscopy. EMBO J. 12:2589-2599.
30. Takayesu, D., J. G. Teodoro, S. G. Whalen, and P. E. Branton. 1994. Characterization of the 55K adenovirus type 5 E1B product and related proteins. J. Gen. Virol. 75:789-798.
31. Tomlinson, M., and K. N. Leppard. Unpublished data.
32. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
33. Vales, L. D., and J. E. Darnell, Jr. 1989. Promoter occlusion prevents transcription of adenovirus polypeptide IX mRNA until after DNA replication. Genes Dev. 3:49-59.
34. van Oostrum, J., and R. M. Burnett. 1985. Molecular composition of the adenovirus type 2 virion. J. Virol. 56:439-448.
35. White, E., and R. Cipriani. 1990. Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein. Mol. Cell. Biol. 10:120-130.
36. Wold, W. S. M., and L. R. Gooding. 1991. Region E3 of adenovirus: a cassette of genes involved in host immunosurveillance and virus-cell interactions. Virology 184:1-8.
37. Yang, Y., F. A. Nunes, K. Berensci, E. E. Furth, E. Gönczöl, and J. M. Wilson. 1994. Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91:4407-4411.