Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells in vitro

Journal of Clinical Investigation

Volumn 96, Issue 6, 1995, Pages 2578-2582

  Carson, William E ^a   Ross, Mary E ^a   Baiocchi, Robert A ^a   Marien, Melanie J ^a   Boiani, Norman ^b   Grabstein, Kenneth ^b   Caligiuri, Michael A ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b AMGEN INC   (United States)

Author keywords

interferon ; interleukin 12; interleukin 15; monocyte; natural killer cell

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2 RECEPTOR; NEUTRALIZING ANTIBODY;

ARTICLE; CELL PROLIFERATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFECTION RISK; LEISHMANIA MAJOR; LIGAND BINDING; LISTERIA MONOCYTOGENES; MONOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL; RECEPTOR BINDING; TOXOPLASMA GONDII;

EID: 0028818320     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118321     Document Type: Article

References (24)

1. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187-376.
2. Robertson, M. J., and J. Ritz. 1990. Biology and clinical relevance of human natural killer cells. Blood. 76:2421-2438.
3. Bancroft, G. J. 1993. The role of natural killer cells in innate resistance to infection. Curr. Opin. Immunol. 4:503-510.
4. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725-3729.
5. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA. 90:6115-6119.
6. Hunter, C. A., C. S. Subauste, V. H. Vancleave, and J. S. Remington. 1994. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice. Regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect. Immun. 62:2818-2824.
7. Sharma, S. D., J. M. Hofflin, and J. S. Remington. 1985. In vivo recombinant interleukin-2 administration enhances survival against a lethal challenge with Toxoplasma gondii. J. Immunol. 135:4160-4163.
8. Caligiuri, M. A., A. Zmuidinas, T. J. Manley, H. Levine, K. A. Smith, and J. Ritz. 1990. Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. J. Exp. Med. 171:1509-1526.
9. Voss, S. D., P. M. Sondel, and R. J. Robb. 1992. Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 γ chain with the IL-2Rβ chain in functional intermediate-affinity IL-2R. J. Exp. Med. 176:531-541.
10. Locksley, R. M. 1993. Interleukin 12 in host defense against microbial pathogens. Proc. Natl. Acad. Sci. USA. 90:5879-5880.
11. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of interferon γ by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869-879.
12. Grabstein, K. H., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, et al. 1994. Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science (Wash. DC). 264:965-968.
13. Carson, W. E., J. G. Giri, M. J. Lindemann, M. L. Linett, M. Ahdieh, R. Paxton, D. Anderson, J. Eisenmann, K. Grabstein, and M. A. Caligiuri. 1994. Interleukin-15 is a novel cytokine which activates human natural killer cells via components of the interleukin-2 receptor. J. Exp. Med. 180:1395-1403.
14. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interteron-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041-1048.
15. Gillis, S., M. M. Ferm, W. Ou, and K. A. Smith. 1977. T cell growth factor: parameters of production and a quantitative microassay for activity. J. Immunol. 120:2027-2032.
16. Hu-Liu, J., J. O'Hara, C. Watyson, W. Tsang, and W. E. Paul. 1989. Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and an IL-2 hyporesponsive mutant of that line (CT.4S). J. Immunol. 142:800-807.
17. Phillips, J. H., T. Tektite, K. Sugamura, and L. L. Lanier. 1989. Activation of natural killer cells via the p75 interleukin 2 receptor. J. Exp. Med. 170:291-296.
18. Matos, M. E., G. S. Schnier, M. S. Beecher, L. K. Ashman, D. E. Williams, and M. A. Caligiuri. 1993. Expression of a functional c-kit receptor on a subset of natural killer cells. J. Exp. Med. 178:1079-1084.
19. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, et al. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387-1398.
20. Baiocchi, R. A., M. E. Ross, J. C. Tan, C. C. Chou, L. Sullivan, S. Haldar, M. Monne, M. V. Seiden, S. K. Narula, J. Sklar, et al. 1995. Lymphomagenesis in the SCID-human mouse involves abundant production of human interleukin-10. Blood. 85:1063-1074.
21. Trinchieri, G., and B. Perussia. 1985. Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol. Today. 6:131-136.
22. Kaye, P. M., and G. J. Bancroft. 1992. Leishmania donovani infection in scid mice: lack of tissue response and in vivo macrophage activation correlates with failure to trigger natural killer cell-derived gamma interferon production in vitro. Infect. Immun. 60:4335-4342.
23. Reiner, S. L., S. Zeng, Z. Wang, L. Stowring, and R. M. Locksley. 1994. Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. J. Exp. Med. 179:447-456.
24. James, S. L., and C. Nacy. 1993. Effector functions of activated macrophages against parasites. Curr. Opin. Immunol. 5:518-524.