In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor

Arthritis & Rheumatism

Volumn 38, Issue 11, 1995, Pages 1678-1686

  Bonassar, Lawrence J ^a   Jeffries, Kimberly A ^a   Frank, Eliot H ^a   Moore, Vernon L ^a   Lark, Michael W ^a   Bayne, Ellen K ^a   Mcdonnell, Joseph ^a   Olszewski, Julie ^a   Hagmann, William ^a   Chapman, Kevin ^a   Grodzinsky, Alan J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

L 696418; METALLOPROTEINASE INHIBITOR; N (1 CARBOXYETHYL) ALPHA PHENETHYLGLYCYLLEUCINE ANILIDE; PROTEOGLYCAN; STROMELYSIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; CONTROLLED STUDY; DRUG EFFECT; HISTOLOGY; INTRAARTICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; JOINT STIFFNESS; KNEE FUNCTION; KNEE OSTEOARTHRITIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; SYNOVIAL FLUID;

ANIMAL; BIOMECHANICS; CARTILAGE, ARTICULAR; DIPEPTIDES; FEMALE; HUMAN; METALLOENDOPEPTIDASES; PROTEASE INHIBITORS; RABBITS; STROMELYSIN 1; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028817843     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.1780381121     Document Type: Article

References (50)

1. The chondrocytes
2. Collagen
3. The mechanical properties of articular cartilage
4. The pathology of osteoarthritis
5. Demonstration of increased proteoglycan turnover in cartilage explants from dogs with experimental osteoarthritis
6. Biochemical changes in the cartilage of the knee in experimental and natural osteoarthrosis in the dog
7. Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis
8. Effects of mechanical loading on the tissues of the rabbit knee
9. Ageing and degeneration
10. Variations in the intrinsic mechanical properties of human articular cartilage with age, degeneration, and water content
11. Balance between swelling pressure and collagen tension in normal and degenerate cartilage
12. Early changes in material properties of rabbit articular cartilage after meniscectomy
13. Acid hydrolase activity in osteoarthritic and normal human cartilage
14. Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis
15. Degradation of proteoglycan aggregate by a cartilage metalloprotease
16. Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium
17. Canine osteoarthritis: effects of endogenous neutral metalloproteoglycanases on articular cartilage proteoglycans
18. The effects of proteolytic enzymes on the mechancial properties of adult human articular cartilage
19. 374 bond of the interglobular domain
20. Stromelysin, a connective tissuedegrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase
21. Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinase‐1 in rheumatoid human synovial fibroblasts
22. Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases: evidence for two converging pathways of chondrocyte‐mediated proteoglycan degradation
23. Purification and characterization of collagenase activator protein synthesized by articular cartilage
24. Stimulation of the synthesis of collagenase activator protein in cartilage by a factor presesnt in synovial‐conditioned media
25. Effects of proteolytic enzymes on the structural and mechanical properties of cartilage
26. Effects of proteoglycan extraction on the tensile properties of articular cartilage
27. Flow‐independent viscoelastic properties of articular cartilage matrix
28. Streaming potentials: a sensitive index of enzymatic degradation in articular cartilage
29. Changes in cartilage composition and physical properties due to stromelysin degradation
30. Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan
31. Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage
32. Heat shock of rabbit synovial fibroblasts increases expression of mRNAs for two metalloproteinases, collagenase and stromelysin
33. Genes for extracellular matrixdegrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammilian development
34. Immonulocalization of metalloproteases and their inhibitor in the rabbit growth plate
35. Electromechanical and physicochemical regulation of cartilage strength and metabolism
36. Cartilage electromechanics. II. A continuum model of cartilage electrokinetics and correlation with experiments
37. Biphasic FEM of frictional creep indentation of articular cartilage
38. Physico‐chemical properties of articular cartilage
39. Production and purification of prostromelysin and procollagenase from IL‐1β‐stimulated human gingival fibroblasts
40. Inhibition of matrix metalloproteinases by n‐carboxyalkyl peptides
41. Periodate‐lysine paraformaldehyde fixative: a new fixative for immunoelectron microscopy
42. Factors influencing metachromatic staining in paraffin‐embedded sections of rabbit and human articular cartilage: a comparison of the safranin O and toluidine blue O techniques
43. Use of an antibody against the matrix metalloproteinase‐generated aggrecan neoepitope FVDIPEN‐COOH to assess the effects of stromelsyin in a rabbit model of cartilage degradation
44. Quantitation of a matrix metalloproteinasegenerated aggrecan G1 fragment using a monospecific antipeptide antiserum
45. The glucose oxidase‐DAB nickel method in peroxidase histochemistry of the nervous system
46. Cartilage electromechanics. I. Electrokinetic transduction and the effects of electrolyte pH and ionic strength
47. Biosynthetic response of cartilage explants to dynamic compression
48. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
49. The different types of chondrocytes and their function in vivo