Stability of Protein Formulations: Investigation of Surfactant Effects by a Novel EPR Spectroscopic Technique

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 12, Issue 1, 1995, Pages 2-11

  Bam, Narendra B ^a   Randolph, Theodore W ^b   Cleland, Jeffrey L ^c  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c GENENTECH INC   (United States)

Author keywords

formulation; label partitioning; protein stability; protein surfactant interaction

Indexed keywords

PROTEIN; RECOMBINANT GAMMA INTERFERON; RECOMBINANT GROWTH HORMONE; SURFACTANT;

ARTICLE; DRUG FORMULATION; DRUG STABILITY; ELECTRON SPIN RESONANCE; PRIORITY JOURNAL; SPECTROSCOPY;

CHEMISTRY, PHARMACEUTICAL; CYCLIC N-OXIDES; DRUG STABILITY; ELECTRON SPIN RESONANCE SPECTROSCOPY; KINETICS; MICELLES; POLYSORBATES; PROTEIN BINDING; PROTEINS; SPIN LABELS; SUPPORT, NON-U.S. GOV'T; SURFACE-ACTIVE AGENTS;

EID: 0028816796     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1016286600229     Document Type: Article

References (46)

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2. Aggregation of insulin, containing surfactants, in contact with different materials
3. Physical stability of insulin formulations
4. Nature of insulin binding to plastic bags
5. Effect of sodium dodecyl sulfate, acid, alkali, urea and guanidine hydrochloride on the circular dichroism of sesamum indicum 1
6. Factors determining the reconstructive denaturation of proteins in sodium dodecyl sulfate solutions. Further circular dichroism studies on structure reorganization of seven proteins
7. Circular dichroism on reconstructive denaturation of proteins by sodium dodecyl sulfate in neutral and acid solutions
8. SDS-catalyzed deamidation of oilseed proteins
9. The binding of sodium dodecyl sulfate to lysozyme in aqueous solutions
10. Assuring the quality of plasma products
11. Interaction of anioinic surfactants with proteins, enzymes and membranes
12. Interaction of anionic surfactants with gelatin: viscosity effects
13. Differences in the solubilizing effectiveness of the soium dodecyl sulfate complexes of various proteins
14. Interactions of proteins with amphipathic substances
15. Polymer-surfactant interactions
16. Physicochemical studies on the interactions between surfactants and globular proteins
17. Use of a surfactant selective electrode in the measurement of the binding of anionic surfactants to bovine serum albumin
18. Ion-selective electrodes for octyl and decyl sulfate surfactants
19. The application of surfactant selective electrodes to the study of surfactant adsorption in colloidal suspension
20. Ionic activities in sodium dodecyl sulfate from electromotive force measurements
21. Protein-surfactant interactions-Nuclear magnetic resonance and binding isotherm studies of interactions between bovine serum albumin and sodium dodecyl sulfate
22. Fluorine chemical shifts in complexes of sodium trifluoralkylsulfates with reduced proteins
23. Proton magnetic resonance studies of the binding of an anionic surfactant with a benzene ring to a protein polypeptide with special reference to SDS-polyacrylamide gel electrophoresis
24. Interaction between hydrophilic proteins and nonionic detergents by surface tension measurements
25. Interaction of bovine serum albumin with detergent cations
26. Changes in adsorbed fibrinogen and albumin interactions with polymers indicated by decreases in detergent elutability
27. Partial dissocitaion and renaturation of embryonic chick d-crystallin. Characterization by ultracentrifugation and circular dichroism
28. Detergent-assisted refolding of guanidinium chloride-denatured rhodanese
29. Binding of the Triton X series of nonionic surfactants to bovine serum albumin
30. The influence of surface composition and molecular diffusion on the stability of foams formed from protein/surfactant mixtures
31. Absorption of recombinant methionyl-human growth hormone from rat nasal mucosa
32. Mechanism of polyethylene glycol interaction with the molten globule folding intermediate of bovine carbonic anhydrase B
33. Dense-gas solvent-solute clusters at near-infinite dilution: EPR spectroscopic evidence
34. Theory of error in factor analysis
35. Thermodynamics of nonioinic polymer-micelle association
36. Studies on the reaction between human growth hormone and oleic acid using polyacrylamide gel electrophoresis
37. Influence of fatty acids on the electrophoretic behavior of proteins with special reference to pituitary hormones and thyroglobulin
38. On the hydrophobic nature of signal sequences
39. Hydrophobic character of amino acid residues in globular proteins