An allosteric hammerhead ribozyme

Bio/Technology

Volumn 13, Issue 2, 1995, Pages 161-164

  Porta, Helena ^a   Lizardi, Paul M ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RIBOZYME; RNA;

ALLOSTERISM; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME REGULATION; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PROTEIN DNA INTERACTION; RNA CLEAVAGE;

ALLOSTERIC REGULATION; BASE SEQUENCE; DRUG DESIGN; ENZYME ACTIVATION; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; POLYMERASE CHAIN REACTION; RNA, CATALYTIC; SUPPORT, NON-U.S. GOV'T; TEMPLATES, GENETIC;

EID: 0028814953     PISSN: 0733222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0295-161     Document Type: Article

References (20)

1. Foster, A. C. and Symons, R. H. 1987. Self-cleavage of plus and minus RNAs of virusoid and a structural model for the active sites. Cell 49:211-220.
2. Foster, A. C. and Symons, R. H. 1987. Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site. Cell 50:9-16.
3. Uhlenbeck, O. 1987. A small catalytic oligonucleotide. Nature 328:596-600.
4. Haseloff, J. and Gerlach, W. L. 1988. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 334:585-591.
5. Miller, W. A. and Silver, S. L. 1991. Alternative tertiary structure attenuates self-cleavage of the ribozyme in the satellite RNA of barley yellow dwarf virus. Nucl. Acids Res. 19:5313-5320.
6. Branch, A. D., Levine, B. J., Baroudy, B. M., Buckler-White, A., Gerin, J. L. and Robertson, H. D. 1991. The novel tertiary structure in delta RNA may function as a ribozyme control element. Prog. Clin. Biol. Res. 364:257-264.
7. Kramer, F. R. and Lizardi, P. M. 1989. Replicatable RNA reporters. Nature 339:401-402.
8. Shore, D., Langowski, J. and Baldwin, R. 1981. DNA flexibility studied by covalent closure of short fragments into circles. Proc. Natl. Acad. Sci. USA 78:4833-4837.
9. Haggerman, P. J. 1988. Flexibility of DNA. Ann. Rev. Biophys. Biophys. Chem. 17:265-286.
10. Goodchild, J. 1992. Enhancement of ribozyme catalytic activity by a contiguous oligodeoxinucleotidc (facilitator) and by 2’-0-Methylation. Nucl. Acids Res. 20:4607-4612.
11. Zuker, M. 1989. On finding all suboptimal foldings of an RNA molecule. Science 244:48-52.
12. Jaeger, J. A., Turner, D. H. and Zuker, M. 1989. Improved predictions of secondary structures for RNA. Proc. Natl. Acad. Sci. USA 86:7706-7710.
13. Bhattacharyya, A. and Lilley, D. M. 1989. The contrasting structures of mismatched DNA sequences containing looped-out bases (bulges) and multiple mismatches (bubbles). Nucl. Acids Res. 1989. 17:6821-6840.
14. Prudent, J. R., Uno, T. and Schultz, P. G. 1994. Expanding the scope of RNA catalysis. Science 264:1924-1927.
15. Saiki, R. K, Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T, Mullis, K. B. and Erlich, H. A. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487-491.
16. Milligan, J. F., Groebe, D. R., Witherell, W. G. and Ulhenbeck, O. C. 1987. Oligoribonucleotidc synthesis using T7 RNA polymerase and synthetic DNA templates. Nucl. Acids Res. 15:8783-8798.
17. Wyatt, R. J., Chastain, M. and Puglisi, D. J. 1991. Synthesis and purification of large amounts of RNA oligonucleotides. Biotechniques 11:764-768.
18. Bock, R. M. and Cherayil, J. D. 1967. Chromatography of sRNA on DEAE-Cellulose and DEAE-Sephadex. Methods in Enzymol. 12:638-644.
19. Bruce, A. G. and Ulhenbeck, O. C. 1978. Reactions at the termini of tRNA with T4 RNA ligase. Nucl. Acids Res. 5:3666-3677.
20. Hertel, K. J., Herschlag, D. and Ulhenbeck, O. C. 1994. A kinetic and thermodynamic framework for the hammerhead ribozyme reaction. Biochemistry 33:3374-3385.