Human antibodies from transgenic mice

International Reviews of Immunology

Volumn 13, Issue 1, 1995, Pages 65-93

  Lonberg, Nils ^a   Huszar, Dennis ^a,b  

^a GenPharm International   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Class switching; Human antibodies; Immunoglobulin genes; Somatic mutation; Targeted mutation; Transgenic mice

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULINS, HEAVY CHAIN; IMMUNOGLOBULINS, LIGHT CHAIN; MONOCLONAL ANTIBODY;

ANIMAL; GENETICS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; REVIEW; TRANSGENIC MOUSE;

ANIMAL; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; HUMAN; IMMUNOGLOBULINS, HEAVY-CHAIN; IMMUNOGLOBULINS, LIGHT-CHAIN; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028814315     PISSN: 08830185     EISSN: None     Source Type: Journal    
DOI: 10.3109/08830189509061738     Document Type: Article

References (102)

1. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ. chain gene
2. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
3. RAG-1 deficient mice have no mature B and T lymphocytes
4. Immunoglobulin gene rearrangements in B cell deficient mice generated by targeted deletion of the JH locus
5. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through cre-lox P-mediated gene targeting
6. Analysis of homozygous mutant chimeric mice: Deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production
7. Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice
8. Rearrangement and expression of rabbit immunoglobulin K light chain gene in transgenic mice
9. Immunoglobulin K light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement
10. A repertoire of monoclonal antibodies with human heavy chains from transgenic mice
11. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate
12. Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus
13. A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins
14. Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome
15. Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin κ locus
16. Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM
17. Antigen-specific human antibodies from mice comprising four distinct genetic modifications
18. Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs
19. RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development
20. Antibodies generated from human immunoglobulin miniloci in transgenic mice
21. Resolution and characterization of pro-B and pre-pro-B cell states in normal mouse bone marrow
22. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
23. Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain
24. Polypeptide chains of human gamma-globulin: cellular localization by fluorescent antibody
25. Utilization of VK families and VK exons. Implications for the available B cell repertoire
26. Physical linkage of the mouse λ genes by pulsed field gel electrophoresis suggests that the rearrangement process favors proximate target sequences
27. B cell development in mice that lack one or both immunoglobulin K light chain genes
28. Gene targeting in the IgK locus: efficient generation of X chain expressing B cells, independent of gene rearrangements in IgK
29. Deletion of the immunoglobulin K chain intron enhancer abolishes K chain rearrangement in cis, but not λ chain rearrangement in trans
30. Antibody response elicited by T-dependent and T-independent antigens in gene targeted K-deficient mice
31. Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus
32. q
33. The human immunoglobulin K locus consists of two copies that are organized in opposite polarity
34. Complete physical map of the human immunoglobulin heavy chain constant region gene complex
35. Germ-line transformation of mice
36. Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus
37. The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements
38. Complex pattern of immunoglobulin JA gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities
39. V(C)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer
40. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus
41. A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus
42. The mouse IgH 3 enhancer
43. An enhancer at the 3′ end of the mouse immunoglobulin heavy chain locus
44. A class switch control region at the 3′ end of the immunoglobulin heavy chain locus
45. Cytokines and Ig switching: evolutionary divergence between mice and humans
46. The immunoglobulin heavy chain locus contains another B-cell-specific 3′ enhancer close to the λ constant region
47. A second promoter and enhancer element within the immunoglobulin heavy chain locus
48. Cu.-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon
49. Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation
50. Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription
51. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus
52. Regulation of transcription of immunoglobulin germ-line γI RNA: analysis of the promoter/enhancer
53. Synthesis of germ-line -γI immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon 7
54. Rapid induction of transcription of unrearranged SγI switch regions in activated murine B cells by interleukin-4
55. The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain γI transcripts correlates with subsequent switching to IgGl
56. Shutdown of class switch recombination by deletion of a switch region control element
57. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching
58. Structure and expression of germ line immunoglobulin 72b transcripts
59. Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes
60. Structure and expression of murine germ-line immunoglobulin ε heavy chain transcripts induced by interleukin 4
61. Structure and expression of germline immunoglobulin γ3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching
62. Germline transcripts of the murine immunoglobulin γ2a gene: structure and induction by IFN-γ
63. A selective defect in IγG2b switching as a result of targeted mutation if the Iγ2b promoter and exon
64. Replacement of germ-line ε promoter by gene targeting alters control of immunoglobulin heavy chain class switching
65. Production of sterile transcripts of Cγ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells
66. Structure and expression of germline ε transcripts in human B cells induced by interleukin 4 to switch to IgE production
67. High-level expression of a human immunoglobulin γI transgene depends on switch region sequences
68. A new human VH family preferentially rearranged in immature B-cell tumours
69. H segments with different hypervariable loops
70. Early restriction of the human antibody repertoire
71. Nucleotide sequence of the V regions of two IgM cold agglutinins
72. Isolation of high affinity human antibodies directly from large synthetic repertoires
73. Expressed human immunoglobulin V genes and their hypermutation
74. The immunoglobulin K locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region
75. Characterization of the human immunoglobulin kappa gene 3′ enhancer: functional importance of three motifs that demonstrate B-cell-specific in vivo, footprints
76. Development of human anti-murine antibody (HAMA) response in patients
77. A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants
78. Current applications of monoclonal antibodies for the therapy of hematopoietic cancers
79. Prospects for the therapeutic use of human monoclonal antibodies
80. Specificity analysis of human monoclonal antibodies reactive with cell surface and intracellular antigens
81. Detection of cell surface and intracellular antigens by human monoclonal antibodies
82. Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes
83. Shutdown of class switch recombination by deletion of a switch region control element
84. A selective defect in IgG2b switching as a result of targeted mutation of the Iγ2b, promoter and exon
85. Production of sterile transcripts of C-y genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells
86. Structure and expression of germline immunoglobulin γ3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching
87. Sequences of human immunoglobulin switch regions: implications for recombination and transcription
88. Regulation of transcription of immunoglobulin germ-line γl RNA: analysis of the promoter/enhancer
89. H5 gene in human B cell chronic lymphocytic leukemia
90. H6- encoded IgM receptors
91. H5 genes used in common B cell chronic lymphocytic leukemia
92. H5 transcripts from three unrelated patients with atopic dermatitis
93. Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated spleen cells
94. DNA sequence of the murine γI switch segment reveals novel structural elements
95. The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain γI transcripts correlates with subsequent switching to IgG1
96. Class switching in human immunoglobulin transgenic mice
97. Interferon-γ and β cell stimulatory factor-1 reciprocally regulate Ig isotype production
98. Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
99. Human immunoglobulin class and IgG subclass regulation: dual action of interleukin-4
100. Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin