Hyperthermia nullifies the ameliorating effect of dizocilpine maleate (MK-801) in focal cerebral ischemia

Brain Research

Volumn 670, Issue 1, 1995, Pages 48-52

  Memezawa, Hajime ^b   Zhao, Qi ^a   Smith, Maj Lis ^a   Siesjö, Bo K ^a  

^a LUND UNIVERSITY   (Sweden)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Brain; Dizocilpine maleate; Focal ischemia; Hyperthermia; Infarct size; Rat

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; HISTOLOGY; HYPERTHERMIA; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; BODY TEMPERATURE; BRAIN ISCHEMIA; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEVER; MALE; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028812335     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(94)01251-C     Document Type: Article

References (27)

1. Distribution of hypoglycenic brain damage: relationship to white matter and cerebrospinal fluid pathways
2. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats
3. The effect of NMDA receptor antagonist, MK-801 on CBF and infarct volume in experimental focal stroke
4. Effect of mild hyperthermia on the ischemic infarct volume after middle cerebral artery occlusion in the rat
5. The effect of hypothermia on transient middle cerebral artery occlusion in the rat
6. Differential outcome to middle cerebral artery occlusion in spontaneously hypertensive strokeprone rats (SHRSP) and Wistar Kyoto (WKY) rats
7. Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat
8. Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats
9. The pharmacotherapy of focal cortical ischaemia in the mouse
10. Free radicals and brain damage due to transient middle cerebral artery occlusion: the effect of dimethylthiourea
11. Experimental studies of ischemic brain edema 1 A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area
12. Fructose-1,6-bisphosphate reduces infarct volume after reversible middle cerebral artery occlusion in rats
13. Middle cerebral artery occlusion without craniotomy in rats; which method works best?
14. Reversible middle cerebral artery occlusion without craniotomy in rats
15. Excitatory amino acid antagonists: opportunities for the treatment of ischaemic brain damage in man
16. Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat
17. Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats
18. Focal Ischemia in the Rat: Factors Modulating Ischemic Damage
19. The significance of brain temperature in focal cerebral ischemia: histopathological consequences of middle cerebral artery occlusion in the rat
20. Correlation between cerebral blood flow and histologic changes in a new ratt model of middle cerebral artery occlusion
21. Quantitative assessment of early brain damage in a rat model of focal cerebral ischemia
22. Antagonists of excitatory amino acid neurotransmitters: a comparison of their effects on global versus focal ischemia
23. Effect of MK-801 on focal brain infarction in normotensive and hypertensive rats
24. Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits
25. Delayed treatment with dextromethorphan and dextrorpoan reduces cerebral damage after transient focal ischemia
26. Hyperthermia complicates middle cerebral artery occlusion induced by an intraluminal filament