Biodegradable poly(l-lactic acid) matrices for the sustained delivery of antisense oligonucleotides

Journal of Controlled Release

Volumn 37, Issue 1-2, 1995, Pages 173-183

  Lewis, Karen J ^a   Irwin, William J ^a   Akhtar, Saghir ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Antisense oligonucleotide; Biodegradable polymer; Drug delivery; Mathematical model; Release profile; Sustained release

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; POLYLACTIC ACID;

ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION; THEORY;

EID: 0028811665     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(95)00100-M     Document Type: Article

References (23)

1. Therapies that make sense
2. Cellular uptake and intracellular fate of antisense oligonucleotides
3. Pharmaceutical aspects of the biological stability and membrane transport characteristics of antisense oligonucleotides
4. Crystallization behaviour and drug release from bacterial polyhydroxyalkanoates
5. Stability of antisense DNA oligodeoxynucleotide analogs in cellular extracts and sera
6. Interactions of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes
7. Polyalkylcyanoacrylate nanoparticles as polymeric particles for antisense oligonucleotides
8. Adsorption of oligonucleotides onto polyisohexylcyanoacrylate nanoparticles protects them against nucleases and increases their cellular uptake
9. Polymers for the controlled parenteral delivery of peptides and proteins
10. In vitro and in vivo evaluation of thyrotropin releasing hormone release from copoly(dl-lactic/glycolic acid) micropsheres
11. Abalation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-kB
12. Long-term treatment of human immunodefiency virus-infected cells with antisense oligonucleotide phosphorothioates
13. In vivo treatment of human leukaemia in a scid mouse model with c-myb antisense oligodeoxynucleotides
14. Antisense Oligonucleotides as therapeutic agents — Is the bullet really magical?
15. Neurite outgrowth in peripherin depleted PC12 cells
16. Nuclease resistant nucleic acid therapeutics
17. Oligodeoxynucleotide stability in subcellular extracts and culture media