The extent and mechanism of the loss of function caused by strongly hypotonic solutions in rat hippocampal slices

Brain Research

Volumn 695, Issue 2, 1995, Pages 195-202

  Huang, R ^a   Aitken, P G ^a   Somjen, G G ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cell swelling; Epilepsy; Extracellular space; Hyponatremia; Neuron damage; Osmotic effect; Seizure; Spreading depression

Indexed keywords

HYPOTONIC SOLUTION;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; EPILEPSY; EVOKED RESPONSE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SYNAPTIC TRANSMISSION;

AGING; ANIMAL; CALCIUM; CELL SIZE; ELECTRIC STIMULATION; EVOKED POTENTIALS; HIPPOCAMPUS; HYPOTONIC SOLUTIONS; IN VITRO; MALE; NEURONS; OSMOLAR CONCENTRATION; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; SPREADING CORTICAL DEPRESSION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SYNAPTIC TRANSMISSION;

EID: 0028811639     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)00777-N     Document Type: Article

References (35)

1. Kainic acid and penicillin: differential effects on excitatory and inhibitory interactions in the CA1 region of the hippocampal slice
2. Optical imaging of physiological changes in hippocampal slices: Spreading depression and hypoxia
3. Seizure and acute osmotic change: clinical and neurophysiological aspects
4. Imaging cell volume changes and neuronal excitation in the hippocampal slice
5. Chlorpromazine protects brain tissue in hypoxia by delaying spreading depression-mediated calcium influx
6. Osmotic effects on the CA1 neuronal population in hippocampal slices with special reference to glucose
7. Hypotonic exposure enhances synaptic transmission and triggers spreading depression in hippocampal tissue slices
8. Transient changes in the size of extracellular space in the sensorimotor cortex of cats in relation to stimulus-induced changes in potassium concentration
9. Calcium dependence of synaptic transmission in the hippocampal slice
10. Osmolality-induced changes in extracellular volume alter epileptiform bursts independently of chemical synapses in the rat: importance of non-synaptic mechanisms in hippocampal epileptogenesis
11. Effects of anoxia on ion distribution in the brain
12. Brain extracellular space during spreading depression and ischemia
13. Role of neuronal synchronizing mechanisms in the propagation of spreading depression in the in vivo hippocampus
14. Analysis of potential shifts associated with recurrent spreading depression and prolonged unstable SD induced by microdialysis of elevated K+ in hippocampus of anesthetized rats
15. Propagation of spreading depression among dendrites and somata of the same cell population
16. Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic transmission
17. Lasting neuron depression induced by high potassium and its prevention by low calcium and NMDA receptor blockade
18. Role of calcium channels in spreading depression in rat hippocampal slices
19. Interstitial volume changes during spreading depression (SD) and SD-like hypoxic depolarization in hippocampal tissue slices
20. Prolonged exposure to high potassium concentration results in irreversible loss of synaptic transmission in hippocampal tissue slices
21. Slow transmission of neural activity in hippocampal area CA1 in absence of active chemical synapses
22. Calcium-sensitive recovery of extracellular potassium and synaptic transmission in rat hippocampal slices exposed to anoxia
23. Osmotic effects upon excitability in rat neocortical slices
24. The neurotoxicity of excitatory amino acids is produced by passive chloride influx
25. Excitotoxicity and the NMDA receptor
26. Calcium fluxes, calcium antagonists and calcium-related pathology in brain ischemia, hypoglycemia and spreading depression: a unifying hypothesis
27. Sustained potential shifts and paroxysmal discharges in hippocampal formation
28. Synchronous neural afterdischarges in rat hippocampal slices without active chemical synapses
29. Postischemic synaptic physiology in area CA1 of the gerbil hippocampus studied in vitro
30. Changes in the diameter of apical dendrites during spreading depression
31. Changes in cortical extracellular space during spreading depression investigated with the electron microscope
32. Calcium, magnesium and long-term recovery from hypoxia in hippocampal tissue slices