Thiazoline Analogues of Epiderstatin, New Inhibitors of Cell Cycle of tsFT-210 Cells

The Journal of Antibiotics

Volumn 48, Issue 10, 1995, Pages 1179-1181

  Rani, B Radha ^a   Cut, Cheng Bini ^a   Osada, Hiroyuki ^a   Ubukata, Makoto ^b  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b TOYAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG ANALOG; EPIDERSTATIN;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTIBIOTICS, ANTINEOPLASTIC; CELL CYCLE; MICE; MICE, INBRED BALB C; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PIPERIDONES; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0028810711     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.48.1179     Document Type: Article

References (5)

1. Ubukata, M.; B. R. Rani, C.-B. Cui & H. Osada: Preparation of optically active epiderstatin and its stereoisomers—Epiderstatin is not a real inhibitor of the mitogenic activity induced by epidermal growth factor—. J. Antibiotics 48: 1176–1178, 1995
2. Dow, R. L.; M. A. Hain & J. A. Lowe III: Total synthesis and stereochemical assignment of (±)-epiderstatin. Tetrahedron Lett. 33: 309 — 312, 1992
3. Nagao, Y.; K. Kawabata & E. Fujita: Efficiently monitored reduction of carboxylic acids into alcohols or aldehydes via 2-thiazoline-2-thio esters by sodium borohydride or di-isobutylaluminium hydride. J. Chem. Soc. Chem. Comm., 330 (1978)
4. Yabuta, G. & K. Mori:Synthesis of some β-substituted δ-lactones and high performance liquid chromatography of the optical purity. Nippon Nogeikagaku Kaishi 56: 1121-1125, 1982
5. Fujisawa, T.; T. Mori & T. Sato: Chemoselective reduction of carboxylic acids into alcohols using N,N-dimethylchlotomethyleniminium chloride and sodium borohydride. Chemistry Letters 835 — 838, 1983