Isolation and Structure of Caribenolide I, a Highly Potent Antitumrr Macrolide from a Cultured Free-Swimming Caribbean Dinoflagellate, Amphidinium sp. S1-36-5

Journal of Organic Chemistry

Volumn 60, Issue 4, 1995, Pages 1084-1086

  Bauer, Ines ^a   Maranda, Lucie ^a   Young, Kurt A ^a   Shimizu, Yuzuru ^a   Fairchild, Craig ^b   Cornell, Laurie ^b   Macbeth, Judy ^b   Huang, Stella ^b  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARIBENOLIDE I; MACROLIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INVERTEBRATE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0028809919     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo00109a050     Document Type: Article

References (15)

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3. Keller, M. D.; Guillard, R. L. In Toxic Dinoflagellates, Anderson, D. M., White, A. W., Baden, D., Ed.; Elsevier: New York, 1985; pp 113-116.
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11. Kobayashi, J.; Ishibashi, M. Chem. Rev. 1993, 93, 1753-1770, and references therein.
12. Ishibashi, M.; Ohizumi, Y.; Hamashima, M.; Nakamura, H.; Hirata, Y.; Sasaki, T.; Kobayashi, J.; J. Chem. Soc., Chem. Commun. 1987, 1127.
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14. In the recently held US/Japan Joint Seminar on Bioorganic Marine Chemistry, we reported the isolation and structure of 1, but a compound with the same skeleton but no furan ring was also reported by Ishibashi, M.; Kobayashi, M. Abstracts of Papers, Japan-U. S. Seminar on Bioorganic Marine Chemistry, Numazu, Japan; Organizing Committee of the 3rd Japan-U. S. Seminar on Bioorganic Marine Chemistry, 1994; p 14.
15. After this manuscript was submitted, the compound was reported in J. Chem. Soc., Chem. Commun. 1994, 1455—1456.