Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells

Journal of Experimental Medicine

Volumn 182, Issue 6, 1995, Pages 2057-2068

  Krueger, James G ^a   Wolfe, Jonathan T ^a   Nabeya, Reiko Tsukifuji ^a   Vallat, Vat Pierre ^a   Gilleaudeau, Patricia ^a   Heftler, Noah S ^a   Austin, Lisa M ^a   Gottlieb, Alice B ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; CELL ANTIGEN; INTEGRIN; INTERLEUKIN 2 RECEPTOR; KERATIN; KI 67 ANTIGEN; SOMATOMEDIN RECEPTOR;

ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; PHOTOTHERAPY; PRIORITY JOURNAL; PSORIASIS; T LYMPHOCYTE; TREATMENT OUTCOME; ULTRAVIOLET B RADIATION; ULTRAVIOLET IRRADIATION;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EPIDERMIS; HUMAN; INTERCELLULAR ADHESION MOLECULE-1; KERATINOCYTES; PSORIASIS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTE SUBSETS; ULTRAVIOLET RAYS;

EID: 0028809898     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.182.6.2057     Document Type: Article

References (51)

1. Mansbridge, J.N., and A.M. Knapp. 1987. Changes in keratinocyte maturation during wound healing. J. Invest. Dermatol. 89: 253-263.
2. Hertle, M.D., M.-D. Kubler, I.M. Leigh, and F.M. Watt. 1992. Aberrant integrin expression during epiDermal wound healing and in psoriatic epiDermis. J. Clin. Invest. 89: 1892-1901.
3. Krane, J.F., D.P. Murphy, A.B. Gottlieb, H. Uyttendaele, D.M. Carter, and J.G. Krueger. 1991. Insulin-like growth factor-1 (IGF-1) receptor expression may regulate keratinocyte proliferative potential in normal and psoriatic epiDermis. J. Invest. Dermatol. 96:544.
4. Bos, J.D., C. Hagenaars, P.K. Das, S.R. Krieg, W.J. Voom, and M.L. Kapsenberg. 1989. Predominance of "memory" T cells (CD4+, CDw20+) over "naive" T cells (CD4+, CD45R+) in both normal and diseased skin. Arch. Dermatol. Res. 281: 24-30.
5. Vallat, V.P., P. Gilleaudeau, L. Battat, J. Wolfe, R. Nabeya, N. Heftier, E. Hodak, A.B. Gottlieb, and J.G. Krueger. 1994. PUVA bath therapy strongly suppresses immunological and epiDermal activation in psoriasis: A possible cellular basis for remittive therapy. J. Exp. Med. 180: 283-296.
6. Gottlieb, A.B., and J.G. Kreuger. 1993. The role of activated T lymphocytes in the pathogenesis of psoriasis. In Psoriasis. L. Dubertret, editor. ISED, Brescia, Italy. 63-71.
7. Baadsgaard, O., G. Fisher, J.J. Voorhees, and K.D. Cooper. 1990. The role of the immune system in the pathogenesis of psoriasis. J. Invest. Dermatol. 95:32S-34S.
8. Henseler, T., and E. Christophers. 1985. Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J. Amer. Acad. Dermatol. 13: 450-456.
9. + T cells in psoriatic lesions preferentially use T-cell receptor Vß3 and/or Vß13.1 genes. Proc. Natl. Acad. Sci. USA. 91: 9282-9286.
10. Bos, J.D., C. Hagenaars, P.K. Das, S.R. Krieg, W.J. Voorn, and M.L. Kapsenberg. 1989. Predominance of "memory" T cells (CD4+, CDw29+) over "naive" T cells (CD4+, CD45R+) in both normal and diseased human skin. Arch. Dermatol. Res. 281: 24-30.
11. Gottlieb, S.L., P. Gilleaudeau, R. Johnson, L. Estes, T.G. Woodworth, A.B. Gottlieb, and J.G. Krueger. 1995. Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nature Medicine. 1: 442-447.
12. Gottlieb, A.B., R.M. Grossman, L. Khandke, D.M. Carter, P.B. Sehgal, S.M. Fu, A. Granelli-Pipemo, M. Rivas, L. Barazani, and J.G. Krueger. 1992. Studies of the effect of cyclosporine in psoriasis in vivo: combined effects on activated T lymphocytes and epiDermal regenerative maturation. J. Invest. Dermatol. 98: 302-309.
13. Krueger, J.G., L. Staiano-Coico, B. Smoller, M. Anzilotti, V.P. Vallat, P. Gilleaudeau, and A.B. Gottlieb. 1995. Endogenous growth factor pathways may regulate epiDermal hyperplasia in chronic venous wounds: modulation by hydrocolloid dressings. In Wound Healing and Skin Physiology. Altmeyer et al., editors. Springer-Verlag, Berlin, pp. 285-302.
14. Tokura, Y. 1992. Mechanisms of local, low-dose UVBinduced immunosuppression in contact hypersensitivity. J. Dermatol 19: 923-931.
15. Friedmann, P.S. 1990. The immunology of allergic contact Dermatitis: the DNCB story. Adv. Dermatol. 5: 175-195.
16. Bazar, L.S., and H.J. Deeg. 1992. Ultraviolet B-induced DNA fragmentation (apoptosis) in activated T-lymphocytes and Jurkat cells is augmented by inhibition of RNA and protein synthesis. Exp. Hematol. 20: 80-86.
17. Teunissen, M.B., R.M. Sylva-Steenland, and J.D. Bos. 1993. Effect of low-dose ultraviolet-B radiation on the function of human T lymphocytes in vitro. Clin. Exp. Immunol. 94: 208-213.
18. Dustin, M.L., K.H. Singer, D.T. Tuck, and T.A. Springer. 1988. Adhesion of T lymphoblasts to epiDermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1). J. Exp. Med. 167: 1323-1340.
19. Gavrieli, Y., Y. Sherman, and S.A. Ben-Sasson. 1992. IDentification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119: 493-501.
20. Trefzer, U., M. Brockhaus, H. Loetscher, F. Parlow, A. Budnik, M. Grewe, H. Christoph, A. Kapp, E. Schoepf, T.A. Luger, and J. Krutmann. 1993. The 55-kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor-alpha and by ultraviolet B radiation. J. Clin. Invest. 92: 462-470.
21. Krane, J.F., A.B. Gottlieb, D.M. Carter, and J.G. Krueger. 1992. The insulin-like growth factor I receptor is overexpressed in psoriatic epiDermis, but is differentially regulated from the epiDermal growth factor receptor. J. Exp. Med. 175: 1081-1090.
22. Casciola-Rosen, L.A., G. Anhalt, and A. Rosen. 1994. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179: 1317-1330.
23. James, L.C., A.M. Moore, L.A. Wheeler, G.A. Murphy, P.M. Dowd, and M.W. Greaves. 1991. Transforming growth factor alpha: in vivo release by normal human skin following UV irradiation and abrasion. Skin. Pharmacol. 4: 61-64.
24. Murphy, G.M., D.G. Quinn, R.D.R. Camp, J.L.M. Hawk, and M.W. Greaves. 1991. In-vivo studies of the action spectrum and time course for release of transforming growth factor-a by ultraviolet irradiation in man. Br. J. Dermatol. 125: 566-568.
25. Livden, J.K., J.R. Bjerke, M. Degre, and M. Matre. 1986. The effect of Goeckerman therapy on interferon in serum and suction blister fluid from patients with psoriasis. Br. J. Dermatol. 114: 217-225.
26. Kock, A., T. Schwarz, R. Kirnbauer, A. Urbanski, P. Perry, J.C. Ansel, and T.A. Luger. 1990. Human keratinocytes are a source of tumor necrosis factor alpha: eviDence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J. Exp. Med. 172: 1609-1614.
27. Konnikov, N., S.H. Pincus, and C.A. Dinarello. 1989. Elevated plasma interleukin-1 levels in humans following ultraviolet light therapy for psoriasis. J. Invest. Dermatol. 92: 235-239.
28. Kirnbauer, R., A. Kock, P. Neuner, E. Forster, J. Krutmann, A. Urbanski, E. Schauer, J.C. Ansel, T. Schwarz, and T.A. Luger. 1991. Regulation of epiDermal cell interleukin-6 production by UV light and corticosteroids. J. Invest. Dermatol. 96: 484-489.
29. Kondo, S., T. Kono, D.N. Sauder, and R.C. McKenzie. 1993. IL-8 gene expression and production in human keratinocytes and their modulation by UVB. J. Invest. Dermatol. 101: 690-694.
30. Soter, N.A. 1990. Acute effects of ultraviolet radiation on the skin. Sem. Dermatol. 9: 11-15.
31. Savage, J.E., A.J. Theron, and R. Anderson. 1993. Activation of neutrophil membrane-associated oxidative metabolism by ultraviolet radiation. J. Invest. Dermatol. 101: 532-536.
32. Grossman, R.M., J. Krueger, D. Yourish, A. Granelli-Piperno, D.P. Murphy, L.T. May, T.S. Kupper, P.B. Sehgal, and A.B. Gottlieb. 1989. Interleukin-6 (IL-6) is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc. Natl. Acad. Sci. USA. 86: 6367-6371.
33. Baker, B., H. Valdimarsson, J.N. Leonard, C.E.M. Griffiths, and L. Fry. 1984. The action of topical steroids, dithranol, and PUVA on T lymphocytes and Dendritic cells in psoriasis. Br.J. Dermatol. 111:702.
34. Anderson, R.R., and J.A. Parrish. 1981. The optics ofhuman skin. J. Invest. Dermatol. 77: 13-19.
35. Mommaas, A.M., A.A. Mulder, M. Vermeer, B.W. Boom, C. Tseng, J.R. Taylor, and J.W. Streilein. 1993. Ultrastructural studies bearing on the mechanism of UVB-impaired induction of contact hypersensitivity to DNCB in man. Exp. Immunol. 92: 487-493.
36. Murphy, G.M., P.G. Norris, A.R. Young, M.F. Corbett, and J.L.M. Hawk. 1993. Low-dose ultraviolet-B irradiation depletes human epiDermal Langerhans cells. Br. J. Dermatol. 129: 674-677.
37. Van Praag, M.C.G., A.A. Mulder, F.H.J. Claas, B.-J. Vermeer, and A.M. Mommaas. 1994. Long-term ultraviolet B-induced impairment of Langerhans cell function: an immunoelectron microscopic study. Clin. Exp. Immunol. 95: 73-77.
38. Krutmann, J., I.U. Khan, R.S. Wallis, F. Zhang, E.A. Rich, J.J. Ellner, and C.A. Elmets. 1990. Cell membrane is a major locus for ultraviolet-B-induced alterations in accessory cells. J. Clin. Invest. 85: 1529-1636.
39. Krutmann, J.K., G.M. Kammer, Z. Toossi, R.L. Waller, J.J. Ellner, and C.A. Elmets. 1990. UVB radiation and human monocyte accessory function: differential effects on premitotic events in T-cell activation. J. Invest. Dermatol. 92: 204-209.
40. Schieven, G.L., J.M. Kirihara, L.K. Gilliland, F.M. Uckun, and J.A. Ledbetter. 1993. Ultraviolet radiation rapidly induces tyrosine phosphorylation and calcium signaling in lymphocytes. Mol. Biol. Cell. 4: 523-530.
41. Gilmour, J.W., J.P. Vestey, and M. Norval. 1993. The effect of UV therapy on immune function in patients with psoriasis. Br.J. Dermatol. 129: 28-38.
42. Kang, K., C. Hammerberg, L. Meunier, and K.D. Cooper. 1994. CDllb+ macrophages that infiltrate human epiDermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of epiDermal IL-10 protein. J. Immunol. 153: 5256-5264.
43. Larko, O. 1982. Phototherapy of psoriasis-clinical aspects and risk evaluation. Acta Dermato-Veneriologica. 103(Suppl.) 1-42.
44. Prinz, J.C., B. Gross, S. Vollmer, P. Trommler, I. Strobel, M. Meurer, and G. Plewig. 1994. T cell clones from psoriasis skin lesions can promote keratinocyte proliferation in vitro via secreted products. Eur.J. Immunol. 24: 593-598.
45. Muehlradt, P.F., H. Quentmeier, and E. Schmitt. 1991. Involvement of interleukin-1 (IL-1), IL-6, IL-2, and IL-4 in generation of cytolytic T cells from thymocytes stimulated by a Mycoplasma fermentans-Denved product. Infect. Immunol. 59: 3962-3968.
46. Fink, S., S. De La Barrera, F. Minnucci, R. Valdez, L.M. Balina, and M.C. Sasiain. 1993. IFN-y, IL-6 and IL-4 modulate M. lepraeor PPD-specific cytotoxic T cells in leprosy patients. Scand.J. Immunol. 38: 551-558.
47. Ritter, M., C. Huber, J. Auboeck, H. Pohl-Markl, J. Troppmair, M. Herold, A. Gaechter, W. Nussbaumer, G. Boeck, D. Nachbaur, et al. 1994. Lytic susceptibility of target cells to cytotoxic T cells is determined by their constitutive major histocompatibility complex class I antigen expression and cytokine-induced activation status. Immunology. 81: 569-577.
48. Doherty, P.C., J.E. Allan, F. Lynch, and R. Ceredig. 1990. Dissection of an inflammatory process induced by CD8+ T cells. Immunol. Today. 11: 55-59.
49. Sale, G.E., P. Anderson, M. Browne, and D. Myerson. 1992. EviDence of cytotoxic T-cell destruction of epiDermal cells in human graft-vs-host disease. Immunohistology with monoclonal antibody TIA-1. Arch. Pathol. Lab. Med. 116: 622-625.
50. Paller, A.S., A. Nelson, L. Steffen, L. Gottschalk, and H. Kaizer. 1988. T-lymphocyte subsets in the lesional skin of allogeneic and autologous bone marrow transplant patients. Arch. Dermatol. 124: 1795-1801.
51. Nickoloff, B.J. 1991. The cytokine network in psoriasis. Arch. Dermatol. 127: 871-884.