Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas

Genes, Chromosomes and Cancer

Volumn 14, Issue 3, 1995, Pages 189-195

  Bartsch, Detlef ^a,b   Shevlin, Douglas W ^a   Tung, William S ^a   Kisker, Oliver ^b   Wells, Samuel A ^a   Goodfellow, Paul J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; REGULATOR PROTEIN;

ALLELE; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL CYCLE; CHROMOSOME 9P; CLINICAL ARTICLE; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN TISSUE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; CARRIER PROTEINS; CODON; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FRAMESHIFT MUTATION; GENES, TUMOR SUPPRESSOR; HUMAN; MUTATION; PANCREATIC NEOPLASMS; POINT MUTATION; PROTEIN P16; SEQUENCE DELETION; SUPPORT, NON-U.S. GOV'T;

EID: 0028809606     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.2870140306     Document Type: Article

References (38)

1. Most human carcinomas of the exocrine pancreas contain mutant c‐K‐ras genes
2. Stepwise transformation of primary thyroid epithelial cells by a mutant ras‐oncogene: An in vitro model of tumor progression
3. Rates of p16 (MTS1) mutations in primary tumors with 9p loss
4. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
5. Detection of K‐ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia
6. Mutations in the RET proto‐oncogene are associated with MEN2A and FMTC
7. p53‐dependent inhibition of cyclin‐dependent kinase activities in human fibroblasts during radiation induced G1 arrest
8. Clinical implications of the p53 tumor‐suppressor gene
9. Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK41 (cyclin‐dependent kinase‐4 inhibitor) gene in human primary non‐small cell lung carcinomas
10. K‐ras oncogene activation in adenocarcinoma of the human pancreas: A study of 82 carcinomas using a combination of mutant‐enriched polymerase chain reaction analysis and allele‐specific oligonucleotide hybridization
11. Germline p16 mutations in familial melanoma
12. A cell cycle regulator potentially involved in genesis of many tumor types
13. Report on the second international workshop on human chromosome 9
14. DNA methylation and cancer
15. Retinoblastoma‐protein‐dependent cell‐cycle inhibition by the tumour suppressor p16.
16. Risk factors for cancer of the pancreas
17. p53 Mutations: Gains or losses?
18. Frequent somatic mutation of the MTS1/CDK41 (multiple tumor suppressor/cyclin‐dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma
19. Deletions of the cyclin‐dependent kinase‐4 inhibitor gene in multiple human cancers
20. Rarity of somatic and germline mutations of the cyclin‐dependent kinase 4 inhibitor gene, CDK41, in melanoma
21. Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers
22. Low frequency of CDKN2 mutation in endometrial carcinomas
23. Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers
24. K‐ras and p53 mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions
25. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
26. Allelotype of pancreatic adenocarcinoma
27. Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma
28. DNA methylation: Molecular biology and biological significance
29. p16 Gene in uncultured tumors
30. Frequent loss of heterozygosity on chromosome 9 in adenocarcinoma and squamous cell carcinoma of the esophagus
31. CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p
32. Sample preparation from paraffinembedded tissues
33. ink4) in human breast carcinomas
34. Frequent c‐Ki‐ras oncogene activation in mucinous cell hyperplasias of pancreas suffering from chronic inflammation
35. Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck
36. The MTS1 gene is frequently mutated in primary human esophageal tumors