Time-resolved detection of lanthanide luminescence for ultrasensitive bioanalytical assays

Journal of Photochemistry and Photobiology, B: Biology

Volumn 27, Issue 1, 1995, Pages 3-19

  Gudgin Dickson, Eva F ^a   Pollak, Alfred ^b   Diamandis, Eleftherios P ^c  

^a ROYAL MILITARY COLLEGE OF CANADA   (Canada)

^b NPS Pharmaceutical Inc   (United States)

^c TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

DNA probing assay; Europium; Immunoassay; Lanthanide chelate; Nucleic acid hybridization assay; Samarium; Terbium; Time resolved fluorescence; Time resolved luminescence

Indexed keywords

EUROPIUM; LANTHANIDE; SAMARIUM; TERBIUM;

DNA PROBE; FLUORESCENCE; IMMUNOASSAY; LUMINESCENCE; PHOTOCHEMISTRY; PRIORITY JOURNAL; REVIEW;

ANIMAL; CHELATING AGENTS; ENZYMES; HUMAN; IMMUNOASSAY; INDICATORS AND REAGENTS; LUMINESCENCE; METALS, RARE EARTH; NUCLEIC ACID HYBRIDIZATION; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

EID: 0028809366     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/1011-1344(94)07086-4     Document Type: Article

References (136)

1. Analytical strategies for the use of DNA probes
2. A decade of development in immunoassay methydology
3. Implementation of immunoassays: Design and equipment of immunoassays
4. Analytical methodology for immunoassays and DNA hybridization assays — Current status and selected systems
5. Applications of fluorescence in immunoassays
6. Nucleic acid hybridization: from research tool to routine diagnostic method
7. The biotin(strept)avidin system: Principles and applications in biotechnology
8. Principles of immunoassays: Principles of non-competitive methods
9. Detection techniques for immunoassay and DNA probing applications
10. Luminescent labels — more than just an alternative to radioisotopes?
11. Applications of dioxetane chemiluminescent probes to molecular biology
12. Principles of immunoassays: Enzymes
13. Background rejection in fluorescence immunoassay
14. Time-resolved fluorescence of lanthanide probes and applications in biotechnology
15. Europium chelate labels in time-resolved fluorescence immunoassays and DNA hybridization assays
16. Chemistry and Spectroscopy of Rare Earths
17. Bioinorganic chemistry: lanthanides as probes in systems of biological interest
18. Energy transfer as a probe of protein dynamics in the proteins transferrin and calmodulin
19. Lanthanide ions as luminescent probes of biomolecular structure
20. Excited state optical activity 1983–1986
21. Lanthanide ion probes of structure in biology. Laser-induced luminescence decay constants provide a direct measure of the number of metal-coordinated water molecules
22. Lanthanide ion luminescence probes of the structure of biological macromolecules
23. Lanthanide ions as fluorescent probes for the nucleotides
24. Luminescence resonance energy transfer
25. Europium as a label in time-resolved immunofluorometric assays
26. Lanthanides as probes for time-resolved fluorometric immunoassays
27. Europium and samarium in time-resolved fluoroimmunoassays
28. Pulsed light, time-resolved fluorometric immunoassay
29. Fluoroimmunoassays and immunofluorometric assays
30. Time-resolved fluorometric immunoassays
31. Time-resolved fluoroimmunoassay
32. Detection of lanthanide chelates by time-resolved fluorescence
33. Preparation of europium-labeled DNA probes and their properties
34. 3+)-labeled oligo DNA hybridization probes
35. Time-resolved fluorometry a sensitive method to quantify DNA-hybrids
36. Detection of biotinylated DNA probes by using Eurolabeled streptavidin and timme-resolved fluorometry
37. Time-resolved fluorometry for the identification of viral DNA in clinical samples
38. Improved detection by time-resolved fluorometry of specific DNA immobilized in microtiter wells with europium/metal-chelator labeled DNA probes
39. 3+) labeled primers in PCR amplification of specific target DNA
40. Detection of Human Immunodeficiency Virus Type I by using the polymerase chain reaction and a time-resolved fluorescence-based hybridization assay
41. 1-antitrypsin deficiency
42. Sensitive detection of genes by sandwich hybridization and time-resolved fluorometry
43. Time-resolved fluorometry in nucleic acid hybridization and Western blotting techniques
44. Time-resolved fluorometer for lanthanide chelates — A new generation of nonisotopic immunoassays
45. The synthesis and use of activated N-benzyl derivatives of diethylenetriamine-tetraacetic acid: Alternative reagents for labelling of antibodies with metal-ions
46. A new fluorescence enhancement solution for europium-based time-resolved fluoroimmunoassays
47. An alternative fluorescence enhancement solution for use in lanthanide-based time-resolved fluoroimmunoassays
48. Co-fluorescence enhancement system based on pivaloyltrifluoroacetone and yttrium for the simultaneous detection of europium, terbium, samarium and dysprosium
49. Analytical application of the cofluorescence effect in detection of europium, terbium, samarium and dysprosium with time-resolved fluorimetry
50. Co-fluorescence effect in time-resolved fluoroimmunoassays: A review
51. Co-fluorescence of europium and samarium in time-resolved fluorimetric immunoassays
52. Lanthanide fluorescence assay for bioaffinity compounds
53. Simultaneous quantification of two plant viruses by double-label time-resolved immunofluorometric assay
54. 1-chymotrypsin
55. Simultaneous assay of α-fetoprotein and free β-subunit of human chorionic gonadotropin by dual-label time-resolved immunofluorometric assay
56. Dual-label time-resolved fluoroimmunoassay for the simultaneous detection of adenovirus and rotavirus in faeces
57. Double-label time-resolved immunofluorometry of lutropin and follitropin in serum
58. Encapsulation of europium in liposomes for use in amplified immunoassay detection system (conference abstract)
59. Cytotoxicity assays using cryopreserved target cells pre-labeled with the fluorescent marker europium
60. Determination of cytotoxic T lymphocyte activity by time-resolved fluorometry using europium-labeled concanavalin A-stimulated cells as targets
61. A fluorescence-based assay for quantitation of lymphokine-activated killer cell activity
62. Determination of cytotoxic T-lymphocyte precursor frequencies using europium labeling as a nonradiative alternative to labeling with chromium-51
63. Modified procedure for labeling target cells in a europium release assay of natural killer cell activity
64. Immunoassays with time-resolved fluorescence spectroscopy: Principles and Applications
65. A new europium chelate for protein labelling and time-resolved fluorometric applications
66. Time-resolved fluorescence using a europium chelate of 4,7-bis-(chlorosulfophenyl)-1,10-phenanthroline-2,9-dicarboxylic acid (BCPDA). Labeling procedures and applications in immunoassays
67. Spectroscopic characterization of 110-phenanthroline-29-dicarboxylic acid and its complexes with europium(III) Luminescent europium chelates useful for analytical applications in aqueous solution
68. Multiple fluorescence labelling with europium chelators. Application to time-resolved fluoroimmunoassays
69. Streptavidin-based macromolecular complex labeled with a europium chelator suitable for time-resolved fluorescence immunoassay applications
70. Multiple labelling and time-resolvable fluoriophores
71. Laser-excited time-resolved solid-phase fluoroimmunoassay with the new europium chelate 4,7-bis(chlorosulfophenyl)-1,10-phenanthroline-2,9-dicarboxylic acid as label
72. Quantitative Western blot analysis and spot immunodetection using time-resolved fluorometry
73. Quantification of nucleic acids on nitrocellulose membranes with time-resolved fluorometry
74. Detection of lanthanide chelates and multiple labeling strategies based on time-resolved fluorescence
75. Time-resolved fluoroimmunoassays with europium chelates as labels
76. Quantification of polymerase chain reaction products in agarose gels with a fluorescent europium chelate as label and time-resolved fluorescence spectroscopy
77. Time-resolved immunofluorometric assays with measurement of a europium chelate in solution: application for sensitive determination of fibronectin
78. Immunoassay of triidothyronine in serum by time-resolved fluorometric measurement of europium-chelate complexes in solution
79. Multianalyte immunoassay based on spatially distinct fluorescent areas quantified by laser-excited solid-phase time-resolved fluorometry
80. Enzyme amplified time-resolved fluoroimmunoassays (conference abstract)
81. Europium (III) cryptate: A fluorescent label for the detection of DNA hybrids on solid support
82. Europium(III) trisbipyridine cryptate label for time-resolved fluorescence detection of polymerase chain reaction products fixed on a solid support
83. Time-resolved fluorescence of a new europium chelate complex: demonstration of highly sensitive detection of protein and DNA samples
84. Synthesis and luminescence of lanthanide complexes of a branched macrocyclic ligand containing 2,2′-bipyridine and 9-methyl-1,10-phenanthroline subunits
85. Terbium chelate for use as label in fluorescent immunoassays
86. Terbium chelate labels for fluorescence immunoassays
87. Multiple labelling of immunoglobulin G, albumin and testosterone with a fluorescent terbium chelate for fluorescence immunoassays
88. Time-resolved fluorometric detection of terbium-labeled deoxyribonucleic acid separated by gel electrophoresis
89. Multiple end labeling of oligonucleotides with terbium chelate-substituted psoralen for time-resolved fluorescence detection
90. Sensitive non-radioactive dot-blot hybridization using DNA probes labeled with chelate group substituted psoralen and quantitative detection by europium ion fluorescence
91. Detection of Escherichia coli rRNA using target amplification and time-resolved fluorescence detection
92. Direct measurement of antigens in serum by time-resolved fluoroimmunoassay
93. Time-resolved pulsed fluorescence immunometric assay of carcinoembryonic antigen
94. Fluorescent lanthanide chelates
95. Homogeneous fluoroassay methods employing fluorescence background rejection and water-soluble rare earth metal chelate fluorophores
96. Novel lanthanide chelate-conjugated oligonucleotides
97. Chelating bipyridine probes for multiple labeling in spectrofluorometric analysis
98. Luminescent lanthanide chelates for immunoassays and other uses, and their preparation
99. Time-resolved lanthanide chelate fluorometric assay
100. Fluorescent lanthanide chelates
101. Preparation and microscopic visualization of multicolor luminescent immunophosphors
102. Inorganic phosphors as new luminescent labels for immunocytochemistry and time-resolved microscopy
103. Lanthanide chelates as new fluorochrome labels for cytochemistry
104. Enzyme-amplified lanthanide luminescence for detection of enzyme labels in ultrasensitive bioanalytical assays
105. Enzyme-Amplified Lanthanide Luminescence for enzyme detection in bioanalytical assays
106. Detection of alkaline phosphatase by time-resolved fluorescence
107. Time-resolved fluorescence detection of enzyme-amplified lanthanide luminescence for nucleic acid hybridization assays
108. Ultrasensitive time-resolved immunofluorometric assay of prostate-specific antigen in serum and preliminary clinical studies
109. Ultrasensitive thyrotropin immunoassay based on enzymatically amplified time-resolved fluorescence with a terbium chelate
110. Enzymatically amplified time-resolved fluorescence immunoassay with terbium chelates
111. Enzymatically amplified time-resolved fluorescence immunoassay with terbium chelates
112. Immunological quantification of advanced glycosylation end-products in the serum of patients on hemodialysis or CAPD
113. Immunoreactive prostate-specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age
114. Quantification of p53 protein tumor cell lines, breast tissue extracts and serum with time-resolved immunofluorometry
115. Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers
116. Autoantibodies against the p53 tumor suppressor gene product quantified in cancer patient serum with time-resolved immunofluorometry
117. Quantitative analysis of mutant p53 protein in breast tumor cytosols and study of its association with other biochemical prognostic indicators in breast cancer
118. Europium and terbium chelators as candidate substrates for enzyme-labeled time-resolved fluorimetric immunoassays
119. Homogeneous time-resolved fluoroimmunoassay of thyroxin in serum
120. Rare earth cryptates and homogeneous fluoroimmunoassays with human sera
121. Nonradioactive assay of DNA hybridization by DNA-template-mediated formation of a ternary Tb(III) complex in pure liquid phase
122. 3+ in a micellar post column reagent
123. Fluorescence of terbium ion-nucleic acid complexes A sensitive specific probe for unpaired residues in nucleic acids