Radiation-induced Apoptosis: Effects of Cell Age and Dose Fractionation

Cancer Research

Volumn 55, Issue 22, 1995, Pages 5207-5212

  Ling, C Clifton ^a   Guo, Min ^a   Chen, Chang Hu ^a   Deloherey, Thomas ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DAMAGE; CELL KINETICS; CELL POPULATION; CYTOFLUOROMETRY; ETIOLOGY; IRRADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RADIOSENSITIVITY; RAT;

ANIMAL; APOPTOSIS; CELL CYCLE; CELLS, CULTURED; CYCLINS; GENES, MYC; PROTEIN P53; RADIATION DOSAGE; RATS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028806631     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Stewart, B. W. Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J. Natl. Cancer Inst., 86: 1286–1296, 1994.
2. Kerr, J. F. R., Wyllie, A. H., and Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 26: 239–257, 1972.
3. Warters, R. L. Radiation-induced apoptosis in a murine T-cell hybridoma. Cancer Res., 52: 883–890, 1992.
4. Sellins, K. S., and Cohen, J. J. Hyperthermia induces apoptosis in thymocytes. Radiat. Res., 126: 88–95, 1991.
5. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H. Thymocyte apoptosis induced by p53-dependent pathways. Nature (Lond.), 362: 849–852, 1993.
6. Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z., and Hancock, D. C. Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69: 119–128, 1992.
7. Fanidi, A., Harrington, E. A., and Evan, G. I. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (Lond.), 359: 554–556, 1992.
8. Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957–967, 1993.
9. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847–849, 1993.
10. Owens, G. P., and Cohen, J. J. Identification of genes involved in programmed cell death. Cancer Metastasis Rev., 11: 149–156, 1992.
11. Shaw, P., Bovey, R., Tardy, S., Sahli, R., Sordat, B., and Costa, J. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA, 89: 4495–4499, 1992.
12. Shi, Y., Glynn, J. M., Guilbert, L. J., Cotter, T. G., Bissonnette, R. P., and Green, D. R. Role for c-myc activation-induced apoptotic cell death in T cell hybridomas. Science (Washington DC), 257: 212–214, 1992.
13. Meyn, R. E., Stephens, L. C., Ang, K. K., Hunter, N. R., Brock, W. A., Milas, L., and Peters, L. J. Heterogeneity in the development of apoptosis in irradiated murine tumors of different histologies. Int. J. Radiat. Biol., 64: 583–591, 1993.
14. Stephens, L. C., Ang, K. K., Schultheiss, T. E., Milas, L., and Meyn, R. E. Apoptosis in irradiated murine tumors. Radiat. Res., 127: 308–316, 1991.
15. Chen, C. H., Zhang, J., and Ling, C. C. Transfected c-myc and c-Ha-ras modulate radiation-induced apoptosis in rat embryo cells. Radiat. Res., 139: 307–315, 1994.
16. Ling, C. C., Chen, C. H., and Li, W. X. Apoptosis induced at different dose rates: implication for the shoulder region of cell survival curves. Radiother. Oncol., 32: 129–136, 1994.
17. Ling, C. C., Chen, C. H., and Fuks, Z. An equation for the dose response of radiation-induced apoptosis: possible incorporation with the LQ model. Radiother. Oncol., 33: 17–22, 1994.
18. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V., and Kastan, M. B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA, 89: 7491–7495, 1992.
19. Nelson, W. G., and Kastan, M. B. DNA strand breaks: the DNA template alterations that trigger p53 DNA damage response pathways. Mol. Cell. Biol., 14: 1815–1823, 1994.
20. Kilmer, B. F., and Henderson, S. D. Cyclic responses of cultured 9L cells to radiation. Radiat. Res., 91: 155–168, 1982.
21. Dewey, W. C., and Humphrey, R. M. Survival of mammalian cells irradiated in different phases of the life-cycle as examined by autoradiography. Nature (Lond.), 198: 1063–1066, 1963.
22. McKenna, W. G., Iliakis, G., Weiss, M. C., Bernhard, E. J., and Muschel, R. J. Increase G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes U-ras and -myc. Radiat. Res., 125: 283–287, 1991.
23. Wagner, A. J., Kokontis, J. M., and Nissam, H. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induced p21 (WAFl/cipl). Genes & Dev., 8: 2817–2830, 1994.
24. Dulic, V., Kaufmann, W. K., Wilson, S. J., Tisty, T. D., Lees, E., Harper, J. W., Elledge, S. J., and Reed, S. I. p53 dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G, arrest. Cell, 76: 1013–1023, 1994.
25. El-Deiry, W. S., Harper, J. W., O'Connor, P. M., Velculesscu, V. E., Canman, C. E., Jackman, J., Pietenpol, J. A., Burrell, M., Hill, D. E., Wang, Y., Wiman, K. G., Mercer, W. E., Kastan, Kohn, K. W., Elledge, S. J., Kinzler, K. W., and Vogelstein, B. WAFl/CIPI is induced in p53-mediated G, arrest and apoptosis. Cancer Res., 54: 1169–1174, 1994.
26. Nagasawa, H., Li, C. Y., Maki, C. G., Imrich, A. C., and Little, J. B. Relationship between radiation-induced G, phase arrest and p53 function in human tumor cells. Cancer Res., 55: 1842–1846, 1995.
27. Mermeking, H., and Eick, D. Mediation of c-Myc-induced apoptosis by p53. Science (Washington DC), 265: 2091–2093, 1994.
28. Yonish-Rouach, E., Grunwald, D., Wilder, S., Kimchi, A., May, E., Lawrence, J., May, P., and Oren, M. p53-mediated cell death: relationship to cell cycle control. Mol. Cell. Biol., 13: 1415–1423, 1993.
29. Elkind, M. M., and Sutton, H. X-ray damage and recovery in mammalian cells in culture. Nature (Lond.), 184: 1293–1295, 1959.