A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

EMBO Journal

Volumn 14, Issue 20, 1995, Pages 5006-5015

  Lee, Chi Hon ^a   Leung, Benjamin ^a   Lemmon, Mark A ^b   Zheng, Jie ^a   Cowburn, David ^a   Kuriyan, John ^a   Saksela, Kalle ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

HIV; PxxP motif; SIV; Tyrosine kinase

Indexed keywords

ISOLEUCINE; MUTANT PROTEIN; NEF PROTEIN; PHOSPHOTRANSFERASE; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME BINDING; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

ACARI; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0028805516     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1995.tb00183.x     Document Type: Article

References (15)

1. Alexandropoulos,K., Cheng,G. and Baltimore,D. (1995) Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc. Natl Acad. Sci. USA, 92, 3110-3114.
2. Brünger,A.T. (1988) X-plor Manual. Howard Hughes Medical Institute and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.
3. Cheng,G., Ye,Z.S. and Baltimore,D. (1994) Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc. Natl Acad. Sci. USA, 91, 8152-8155.
4. Cicchetti,P., Mayer,B.J., Thiel,G. and Baltimore,D. (1992) Identification of a protein that binds to the SH3 region of Abl and is similar to Ber and GAP-rho. Science, 257, 803-806.
5. Cohen,G., Ren,R. and Baltimore,D. (1995) Modular binding domains in signal transduction proteins. Cell, 80, 237-248.
6. Eck,M.J., Atwell,S.K., Shoelson,S.E. and Harrison,S.C. (1994) Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature, 368, 764-769.
7. Erpel,T., Superti-Furga,G. and Courtneidge,S.A. (1995) Mutational analysis of Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions. EMBO J., 14, 963-975.
8. Feng,S., Chen,J.K., Yu,H., Simon,J.A. and Schreiber,S.L. (1994) Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science, 266, 1241-1247.
9. Huang,Y., Zhang,L. and Ho,D.D. (1995) Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J. Virol., 69, 93-100.
10. Jones,T.A., Zou,J.Y., Cowan,S.W. and Kjeldgaarn,M. (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr., A47, 110-119.
11. Kato,J.Y., Takeya,T., Grandori,C., Iba,H., Levy,J.B. and Hanafusa,H. (1986) Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein. Mol. Cell. Biol., 6, 4155-4160.
12. Kawakami,T., Pennington,C.Y. and Robbins,K.C. (1986) Isolation and oncogenic potential of a novel human src-like gene. Mol. Cell. Biol., 6, 4195-201.
13. Knudsen,B.S., Feller,S.M. and Hanafusa,H. (1994) Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology domain of Crk. J. Biol. Chem., 269, 32781-32787.
14. Knudsen,B.S., Zheng,J., Feller,S.M., Mayer,J.P., Burrell,S.K., Cowburn,D. and Hanafusa,H. (1995) Affinity and specificity requirements for the first Src homolgy 3 domain of the Crk proteins. EMBO J., 14, 2191-2198.
15. Kuriyan,J. and Cowburn,D. (1993) The structures of SH2 and SH3 domains. Curr. Opin. Struct. Biol., 3, 828-837.