Expression of human thyrotropin in cell lines with different glycosylation patterns combined with mutagenesis of specific glycosylation sites: Characterization of a novel role for the oligosaccharides in the in vitro and in vivo bioactivity

Journal of Biological Chemistry

Volumn 270, Issue 49, 1995, Pages 29378-29385

  Grossmann, Mathis ^a   Szkudlinski, Mariusz W ^a   Tropea, Joseph E ^a   Bishop, Leonora A ^b   Thotakura, N Rao ^a   Schofield, Peter R ^b   Weintraub, Bruce D ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; OLIGOSACCHARIDE; THYROTROPIN; THYROTROPIN RECEPTOR;

ANIMAL CELL; ARTICLE; GENE SEQUENCE; HORMONE SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; THYROTROPIN RELEASE;

ANIMAL; CHO CELLS; CYCLIC AMP; GLYCOSYLATION; HALF-LIFE; HAMSTERS; HUMAN; MALE; MICE; MUTAGENESIS, SITE-DIRECTED; N-ACETYLNEURAMINIC ACID; OLIGOSACCHARIDES; RATS; RECOMBINANT PROTEINS; SIALIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; THYROTROPIN;

EID: 0028805384     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.270.49.29378     Document Type: Article

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