Interaction of Bovine Brain Tubulin with the 4(lH)-Pyrizinone Derivative IKP104, an Antimitotic Drug with a Complex Set of Effects on the Conformational Stability of the Tubulin Molecule

Biochemistry

Volumn 34, Issue 48, 1995, Pages 15751-15759

  Luduena, Richard F ^a   Carmen Roach, Mary ^a   Prasad, Veena ^a   Ray Chaudhuri, Asish ^a   Tomita, Isao ^b   Mizuhashi, Fukutaro ^c   Murata, Kyoji ^d  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c Kumiai Chemical Industry Co ^*

^d KUMIAI CHEMICAL INDUSTRY CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 CHLORO 3,5 DIMETHOXYPHENYL) 2 (4 FLUOROPHENYL) 3 METHYL 6 PHENYL 4(1H) PYRIDINONE; ANTIMITOTIC AGENT; COLCHICINE; DOLASTATIN 10; HALICHONDRIN B; MAYTANSINE; PHOMOPSIN A; PODOPHYLLOTOXIN; RHIZOXIN; TUBULIN; VINBLASTINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CATTLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY;

ALKYLATION; ANIMAL; ANTINEOPLASTIC AGENTS; BRAIN; CARBON RADIOISOTOPES; CATTLE; COLCHICINE; IODOACETAMIDE; MITOSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PYRIDONES; SULFHYDRYL COMPOUNDS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRITIUM; TUBULIN;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0028805270     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00048a020     Document Type: Article

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