Reproductive toxicity screen of 1,3,5-trinitrobenzene administered in the diet of sprague-dawley rats

Toxicology and Industrial Health

Volumn 11, Issue 3, 1995, Pages 309-323

  Kinkead, E R ^a   Wolfe, R E ^a   Flemming, C D ^a   Caldwell, D J ^b   Miller, C R ^b   Marit, G B ^c  

^a ALION SCIENCE AND TECHNOLOGY   (United States)

^b WRIGHT PATTERSON AIR FORCE BASE   (United States)

^c AIR FORCE RESEARCH LABORATORY   (United States)

Author keywords

dietary; explosives; methemoglobinemia; nitrate; oral; reproductive screen; TNB

Indexed keywords

TRINITROBENZENESULFONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEMALE; HEMOSIDEROSIS; MALE; MATING; METHEMOGLOBINEMIA; MORTALITY; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SPLEEN; WEIGHT REDUCTION;

ANIMAL; FEMALE; FOOD CONTAMINATION; HEMOSIDEROSIS; KIDNEY DISEASES; MALE; METHEMOGLOBINEMIA; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; SPERM MOTILITY; SPLENIC DISEASES; SUPPORT, U.S. GOV'T, NON-P.H.S.; TESTICULAR DISEASES; TRINITROBENZENES;

EID: 0028805167     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/074823379501100302     Document Type: Article

References (24)

1. BARCIKOWSKI, R.S. (ed.) (1983). Computer Packages and Research Design. University Press of America, Lanham, MD.
2. Barnhart, R.R. (1981). “Rubber compounding.” In: Kirk-Othmer Encyclopedia of Chemical Technology (A. Stannden, ed.). 3rd ed., Vol. 20. John Wiley and Sons, New York, NY. pp. 393-468.
3. BUDAVARI, S., O'NEIL, M.J., and SMITH, A. (eds.) (1989). “ An encyclopedia of chemicals, drugs and biologicals.” In: The Merck Index. Merck and Co., Inc., Rahway, NJ. p. 1530.
4. Cody, T.E., Witherup, S., Hastings, R., Stemmer, K., and Christian, R.T. (1981). “1,3-Dinitrobenzene: Toxic effect in vivo and in vitro” J. Toxicol. Environ. Health 7(5):829-847.
5. FEDOROFF, B.T., SHEFFIELD, O.E., REESE, E.F., and CLIFT, G.D. (eds.) (1962). Encyclopedia of Explosives and Related Items. PATR 2700, Vol. 2. Picatinny Arsenal, Dover, NJ. pp. B48-B49.
6. Fitzgerald, C.B., Digiulio, N., Desai, L.S., and Reddy, G. (1992). “Acute toxicological evaluation of 1,3,5-trinitrobenzene “ Acute Toxicity Data 1(3):169-170.
7. Furedi, E.M., Levine, B.S., Gordon, D.E., Rac, V.S., and Lish, P.M. (1984a). “Determination of the chronic mammalian toxicologic effects of TNT [24-month chronic toxicity/carcinogenicity study of trinitrotoluene (TNT) in the Fischer 344 rat]” Final Report — Phase III, Vol. 1. IIT Research Institute, Project No. L6116, Study No. 11, Chicago, IL. DAMD17-79-C-9120. AD-A168 754.
8. Furedi, E.M., Levine, B.S., Sagartz, J.W., Rac, V.S., and Lish, P.M. (1984b). “Determination of the chronic mammalian toxicologic effects of TNT [24-month chronic toxicity/carcinogenicity study of trinitrotoluene (TNT) in the B6C3F1 hybrid mouse]” Final Report - Phase IV, Vol. 1. IIT Research Institute, Project No. L6116, Study No. 11, Chicago, IL. DAMD17-79-C-9120. AD-A168 754.
9. Hathaway, J.A. (1977). “Trinitrotoluene: A review of reported dose-related effects providing documentation for a workplace standard.” J. Occup. Med. 19(5):341-345.
10. Kinkead, E.R., Bunger, S.K., Kimmel, E.C., Flemming, C.D., Wall, H.G., and Grabau, J.H. (1991). “Effects of a 13-week chloropentafluorobenzene inhalation exposure of Fischer 344 Rats and B6C3F1 mice.” Toxicol. Ind. Health 7(4):309-318.
11. Kinkead, E.R., Wolfe, R.E., Salins, S.A., Flemming, C.D., Caldwell, D.J., Miller, C.R., and Latendresse, J.R. (1994a). “Range-finding study for a reproductive assessment of 1,3,5-trinitrobenzene administered in the diet of Sprague-Dawley rats.” AL-TR-1994-072/WRAIR-TR-1994-0006. Armstrong Laboratory and Walter Reed Army Institute of Research, Wright-Patterson Air Force Base, OH.
12. Kinkead, E.R., Wolfe, R.E., Salins, S.A., Miller, C.R., and Latendresse, J.R. (1994b). “Single generation reproductive study of 1,3,5-trinitrobenzene administered in the diet of Sprague-Dawley rats” Toxicologist 14: 574.
13. Levine, B.S., Rust, J.H., Burns, J.M., and Lish, P.M. (1983). “Determination of the chronic mammalian toxicological effects of TNT [26-week subchronic oral toxicity study of trinitrotoluene (TNT) in the beagle dog].” Phase II, Final Report, IIT Research Institute, Report No. L6116, Study No. 5, Chicago, IL. DAMD 17-79-C-9120, AD-A 157 082.
14. Levine, B.S., Furedi, E.M., Gordon, D.E., Lish, P.M., and Barkely, J.J. (1984). “Subchronic toxicity of trinitrotoluene in Fischer 344 rats.” Toxicology 32: 253-265.
15. Linder, R.E., Hess, R.A., and Strader, L.F. (1986). “Testicular toxicity and infertility in male rats treated with 1,3-dinitrobenzene.” J. Toxicol. Environ. Health 19: 477-489.
16. Linder, R.E., Strader, L.F., Barbee, R.R., Rehnberg, G.L., and Perreault, S.D. (1990). “Reproductive toxicity of a single dose of 1,3-dinitrobenzene in two ages of young adult male rats.” Fundam. Appl. Toxicol. 14: 284-298.
17. Morton, A.R., Ranadive, M.V., and Hathaway, J.A. (1976). “Biological effects of trinitrotoluene from exposure below the threshold limit value.” Am. Ind. Hyg. Assoc. J. 37( 1 ):56-60.
18. Philbert, M.A., Gray, A.J., and Connors, T.A. (1987). “Preliminary investigations into the involvement of the intestinal microfluora in CNS toxicity induced by 1,3-dinitrobenzene in male F-344 rats.” Toxicol. Lett. 38: 307-314.
19. Rosner, B. (1990). Fundamentals of Biostatistics PWS-Kent Publishing Co., Boston, MA.
20. Ryon, M.G., Pal, B.C., Talmage, S.S., and Ross, R.H. (1984). Database assessment of the health and environmental effects of munition production waste products Final Report. ORNL-6018. (NTIS DE84-016512). Oak Ridge National Laboratory, Oak Ridge, TN.
21. Sokal, R.R. and Rohlf, F.J. (1981). Biometry 2nd ed. W.W. Freeman and Company, New York, NY. pp. 293-317.
22. Stewart, A., Witts, L.T., Higgins, G., et al. (1945). “Some early effects of exposure to trinitrotoluene.” Br. J. Ind. Med. 2: 74-82.
23. Toth, G.P., Wang, S.R., McCarthy, H., Tocco, D.R., and Smith, M.K. (1992). “Effects of three male reproductive toxicants on rat cauda epididymal sperm motion.” Reprod. Toxicol. 6: 507-515.
24. U.S. Environmental Protection Agency (Epa) ( 1989). Health and Environmental Effects Profile for 1,3,5-Trinitrobenzene. ECAO-CIN-G071. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Cincinnati, OH.