Effects of caloric restriction on age-related oxidative modifications of macromolecules and lymphocyte proliferation in rats

Free Radical Biology and Medicine

Volumn 19, Issue 6, 1995, Pages 859-865

  Tian, Liqun ^a   Cai, Qiuyin ^a   Bowen, Ronald ^a   Wei, Huachen ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Aging; Caloric restriction; Fischer 344 X BNFI rats; Free radicals; Lipid peroxidation; Lymphocyte proliferation; Oxidative modification; Protein oxidation; Reactive oxygen species

Indexed keywords

CONCANAVALIN A; PHYTOHEMAGGLUTININ; REACTIVE OXYGEN METABOLITE;

ADOLESCENT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; ENZYME INACTIVATION; IMMUNE RESPONSE; LIPID PEROXIDATION; LYMPHOCYTE PROLIFERATION; MALE; MEMBRANE DAMAGE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; SENESCENCE; T LYMPHOCYTE;

AGING; ANIMAL; BLOOD PROTEINS; CONCANAVALIN A; ENERGY INTAKE; LYMPHOCYTE ACTIVATION; MALE; MALONDIALDEHYDE; OXIDATION-REDUCTION; PHYTOHEMAGGLUTININS; PROTEINS; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; SPLEEN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028804980     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(95)00090-K     Document Type: Article

References (38)

1. Immunological response in an elderly population with a mean age of 85
2. Lymphocyte responses to Varicella zoster virus in the elderly
3. Mechanism of the age-related decline in lymphocyte proliferation: role of IL-2 production and protein synthesis
4. Age-related changes in T cell function
5. The cellular and subcellular bases of immunosenescence
6. Aging and immune function
7. Cell biology of the impaired proliferation of T cells from elderly humans
8. Age-related effects in T cell activation and proliferation
9. The immune response of aged mice to influenza: Diminished T-cell proliferation, interleukin-2 production and cytotoxicity
10. Age influence on the thymic capacity to promote differentiation of T cells: Induction of different composition of T cell subsets by aging thymus
11. Aging and lymphokine production by T cell subsets
12. Aging and immune function: Cellular and biochemical analysis
13. Influence of weaning-initiated dietary restriction on response to T cell mitogens and splenic T cell levels in a long-lived Fl-hybrid mouse strain
14. The effect of dietary restriction on mouse T cell function
15. The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake
16. Tumorigenic effects of direct- and indirect-acting chemical carcinogens in rats on a restricted diet
17. Dietary restriction in mice beginning at 1 year of age: Effect on life-span and spontaneous cancer incidence
18. Modulation of age-related alterations in membrane composition and receptor-associated immune functions by food restriction in Fischer 344 rats
19. Free radical theory of aging
20. Mitochondrial production of prooxidants and cellular senescence
21. Food restriction in female Wister rats: VI. Effect of reduced glutathione on the proliferative response of splenic lymphocytes from ad lib fed and food restricted animals
22. Free radical theory of aging: Beneficial effect of antioxidants on the lifespan of male NZB mice; role of free radical reactions in the deterioration of the immune system with age and in the pathogenesis of systemic lupus erythematosus
23. Age-and maturation-dependent changes in the immune system of Fischer F344 rats
24. Determination of carbonyl content in oxidatively modified proteins
25. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction
26. Biochemistry of oxygen toxicity
27. Oxygen radical release in mitochondria: Influence of age
28. Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species
29. Oxidative phenomena are implicated in human T-cell stimulation
30. Membrane fluidity, reactive oxygen species, and cell-mediated immunity: Implications in nutrition and disease
31. Age-dependent modifications of mitochondrial trans-membrane potential and mass in rat splenic lymphocytes during proliferation
32. Lipid peroxidation and mtDNA degeneration
33. Oxidative and other DNA damages as the basis of aging: A review
34. Protein oxidation and aging
35. + influx by food restriction in aging rats
36. Effect of chronic food restriction in aging rats. I. Liver subcellular membranes
37. Dietary modulation of DNA damage in human
38. Retardation of the aging processes in rats by food restriction