M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

Nature Genetics

Volumn 11, Issue 4, 1995, Pages 447-449

  Souza, Angus T De ^a   Hankins, Gerald R ^b   Washington, Mary K ^b   Orton, Terry C ^a   Jirtle, Randy L ^b  

^a ASTRAZENECA   (United Kingdom)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ARTICLE; CHROMOSOME LOSS; CHROMOSOME MAP; ENZYME DEGRADATION; ENZYME INHIBITION; GENE AMPLIFICATION; GENE MUTATION; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTRON; LIVER CELL CARCINOMA; POINT MUTATION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CATTLE; DNA MUTATIONAL ANALYSIS; EXTRACELLULAR SPACE; GENES, TUMOR SUPPRESSOR; HETEROZYGOTE; HUMAN; LIVER NEOPLASMS; MICE; MOLECULAR SEQUENCE DATA; POINT MUTATION; RATS; RECEPTOR, IGF TYPE 2; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028804071     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1295-447     Document Type: Article

References (22)

1. Kornfild, S. Structure and function of the mannose 6-phosphate/tnsulin-llke growth factor II receptors. A Rev Biochem. 61, 307-330 (1992).
2. Dennis, RA & Rifkin, D. B. Cellular activation of latent transforming growth factor β requires binding to the cation-independent mannose 6-phosphaterînsulirvliko growth factor type II receptor. Proc. natn. Acad. Sci. USA 88, 580-584 (1991).
3. Yang, D. & Rogíar; C. E. Analysis of insvün-ftke growth factor íl (IGF-II) expression in neoplastic nodules and hepatocellular carcinomas of woodchucks utilizing in situ hybridization and immunocytochemistry. Carcinogenesis 12, 1893-1901 (1991).
4. Osborne, C. K. et al. Insulin-like growth factor II (IGF-ll): a potential autocrine/paracrine growth factor for human breast cancer acting via the IGF-I receptor. Molec. Endocr. 3, 1701-1709 (1989).
5. Chrislofori, G., Naík, R&Hanahan, DA. Socond signal supplied by insultn like growth factor II in oncogene-induced tumorigenesis. Nature 38B, 414-417 (1994).
6. Singer, C. et al. Malignant breast epithelium selects for insulin-like growth factor li expression in breast stroma: evidence for paracrine function. Cancer Res. 55, 2448-2454(1995).
7. De Souza, A. T. et al. Frequent loss of heterozygosity on 6q at the mannose 6-phoephata'insiJin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene 10, 1725-1729 (1995).
8. Laureys, G., Barton, D. E., Ullrich, A. & Francke, U. Chromosomal mapping of the gene for the type II insulirvfike growth factor receptor/catiorHndependent mannose 6-phosphate receptor in man and mouse. Genomics 3, 224-229 (1988).
9. Szebenyi, G. & Rotweh, R The mouse insulin-llke growth factor ll/cation-indeperiderrt mannose 6-phosphate (K3F-IL/MPR) receptor gene: molecular cloning and genomic organization. Genomics 19, 120-129 (1994).
10. Horowitz, D. S. & Krainer, A. R. Mechanisms for selecting 5 spüce sites in mammalian pre-mRNAspfidng. Trends Genet 10, 100-106(1994).
11. Padgett, R A, Grabowski, RJ., Konarska, M. M., Seiler, S. & Sharp, PA Splicing of messenger RNA precursors. A Rev. Biochem. 55, 1119-1150(1986).
12. Wang, Z-Q., Fung, M. R., Bartow, D. P. & Wagner, E. Regulation of embryonic growth and lysosomal targeting by the imprinted IGF2/Mpr gene. Nature 372, 464-467(1994).
13. Hartshorn, MA, Scott, C. D. & Baxter, R. C. Immunoftuorescent localization of type II insulin-like growth factor receptor in rat liver and hepatoma cells. J. Endocr. 121, 221-227(1988).
14. Westlund, B., Dahms, N. M. & Komfeld, S. The bovine mannose 6-phosphatetfnsulin-iike growth factor II receptor, localization of mannose 6-phosphate binding sites to domains 1-3 and 7-11 of the extra cytoplasmic region, J. bioi. Chem. 266, 23233-23239 (1991).
15. Dahms, N. M., Rose, RA., Molkentin, J. D., Zhang, Y. & Brzycki, MA The bovine mannose 6-phosphate/insulin-like growth factor II receptor, tie role of arginine residues in mannose 6-phosphate binding. J. bioi. Chem. 288, 5457-5463 (1993).
16. Dahms, H. M., Wick, DA & Brzycki-Wesseil, MA The bovine mannose 6-phosphate/insulirHike growth factor II receptor, localization of the irtsultn-like growth factor II binding site to domains 5-11. J. bioi. Chem. 269, 3802-3809(1994).
17. Barlow, DP., Stöger, R., Herrmann, B. G., Saito, K. & Schweifer, N. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature 340, 84-87 (1991).
18. Xu, Y., Goodyer, C. G., Deal, C. & Polychronakos, C. Functional polymorphism in the parental imprinting of the human IGF2R gene. Biochem. biophys. Res. Commun. 197, 747-754(1993).
19. Katscheuer, V. M., Mariman, E. C., Schepens, M. T., Rehder, H. & Ropers, H.-H. The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans. Nature Genet. 5, 74-78 (1993).
20. Ogawa, O., McNoe, LA, Eccles, M. R., Morison, I. M. & Reeve, A. E. Human insulinlike growth factor type I and type II receptors are not imprinted. Hum. molec. Genet 2, 2163-2165(1993).
21. Causin, C. et al. Mannose 6-phosphat/insulin-like growth factor ií-binding proteins in human serum and urine, their relation to the mannose 6-phosphate/insulin-like growth factor II receptor. Biochem. J. 252, 795-799 (1988).
22. Jiröe, R. L, Hankins, G. R., Reisenbichler, H. & Boyer, I. J. Regulation of mannose 6-phosphate/insulin-like growth factor-ll receptors and transforming growth factor beta during liver tumor promotion with phenobarbetal. Carcinogenesis 15, 1473-1478(1994).