Cytostatic activity of phenylacetate and derivatives against tumor cells. Correlation with lipophilicity and inhibition of protein prenylation

Biochemical Pharmacology

Volumn 50, Issue 8, 1995, Pages 1273-1279

  Hudgins, W Robert ^a   Shack, Sonsoles ^a   Myers, Charles E ^b   Samid, Dvorit ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

aromatic fatty acids; cytostasis; glioblastoma; lipophilicity; melanoma; phenotypic reversion; plants; prostate cancer

Indexed keywords

1 NAPHTHYLACETATE; 2 CHLOROPHENYLACETIC ACID; 2 METHYLPHENYLACETIC ACID; 2,6 DICHLOROPHENYLACETIC ACID; 3 CHLOROPHENYLACETIC ACID; 3 METHYLPHENYLACETIC ACID; 4 CHLOROPHENYLACETIC ACID; 4 CHLOROPHENYLBUTYRIC ACID; 4 FLUOROPHENYLACETIC ACID; 4 HYDROXYPHENYLACETIC ACID; 4 IODOPHENYLACETIC ACID; 4 IODOPHENYLBUTYRIC ACID; 4 METHYLPHENYLACETIC ACID; ALPHA ETHYLPHENYLACETIC ACID; ALPHA METHOXYPHENYLACETIC ACID; ALPHA METHYLPHENYLACETIC ACID; ANTINEOPLASTIC AGENT; AROMATIC COMPOUND; FATTY ACID; PHENYLACETIC ACID; PHENYLBUTYRIC ACID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOSTASIS; DRUG MECHANISM; DRUG UPTAKE; GLIOBLASTOMA; HUMAN; HUMAN CELL; LIPOPHILICITY; MELANOMA; PHENOTYPE; PLANT CELL; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN MODIFICATION; TUMOR CELL;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL DIVISION; CELL LINE; CELL SURVIVAL; COMPARATIVE STUDY; DRUG DESIGN; HUMAN; LIPIDS; PHENOTYPE; PHENYLACETATES; PROTEIN ISOPRENYLATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0028802943     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02013-3     Document Type: Article

References (31)

1. Phenylacetate: A novel nontoxic inducer of tumor cell differentiation
2. A phase I and pharmacokinetics study of intravenous phenylacetate in patients with cancer
3. Induction of erythroid differentiation and fetal hemoglobin production in human leukemic cells treated with phenylacetate
4. Selective growth arrest and maturation of prostate cancer cells in vitro by nontoxic, pharmacological concentrations of phenylacetate
5. Selective activity of phenylacetate against malignant gliomas: Resemblance to fetal brain damage in phenylketonuria
6. Growth inhibition, tumor maturation, and extended survival in experimental brain tumors treated with phenylacetate
7. Phenylacetate synergizes with retinoic acid in inducing the differentiation of human neuroblastoma cells
8. Synergistic inhibition of human rhabdomyosarcoma cells by sodium phenylacetate and tretinoin
9. Differentiation of cultured human melanoma cells induced by the aromatic fatty acids, phenylacetate and phenylbutyrate
10. Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis
11. Waste nitrogen excretion via amino acid acylation: Benzoate and phenylacetate in lysinuric protein intolerance
12. Der Abbau aromatischen Fettsäuren im Tierkörper
13. Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate
14. Identification of phenylacetic acid as a natural auxin in the shoots of higher plants
15. Structure-activity relationship in the auxin activity of mono-substituted phenylacetic acids
16. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay
17. The structure-activity relationship in barbiturates and its similarity to that in other narcotics
18. Influence of phenylacetic acid on poly-β-hydroxybutyrate (PHB) polymerization and cell elongation in Azotobacter chroococcum Beij
19. Metabolism of dl-phenylalanine by Aspergillus niger
20. Protein prenylation: A mediator of protein-protein interactions
21. The effect of aromatic CoA esters on fatty acid synthetase: Biosynthesis of ω-phenyl fatty acids
22. Inhibition of chick brain cholesterogenic enzymes by phenyl and phenolic derivatives of phenylalanine
23. Regulation of cytosolic HMG-CoA reductase activity in pea seedlings: Contrasting responses to different hormones, and hormone-product interaction, suggest hormonal modulation of activity
24. Metilirovanie DNK v porostkach psenicy i vlijanije fytogormonov (in Russ.)
25. Phenylacetate in chemoprevention: In vitro and in vivo suppression of 5-aza-2′-deoxycytidine induced carcinogenesis
26. Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta thal-assemia
27. Increased fetal hemoglobin in patients receiving sodium 4-phenylbutyrate
28. Growth signal pathways
29. Phase I study of phenylacetate administered twice daily to patients with cancer