Genetic control of multiple sclerosis: Increased production of lymphotoxin and tumor necrosis factor‐α by HLA‐DR2+ T cells

Annals of Neurology

Volumn 38, Issue 5, 1995, Pages 723-730

  Zipp, Frauke ^a   Weber, Frank ^a   Huber, Susanne ^a   Sotgiu, Stefano ^a   Czlonkowska, Anna ^a   Holler, Ernst ^b   Albert, Ekkehard ^b   Weiss, Elisabeth H ^b   Wekerle, Hartmut ^a   Hohlfeld, Reinhard ^a,b  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; HLA DR2 ANTIGEN; LYMPHOTOXIN; MYELIN BASIC PROTEIN; TETANUS TOXOID; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; GENETIC SUSCEPTIBILITY; HLA TYPING; HUMAN; HUMAN CELL; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMAL; BASE SEQUENCE; CELL LINE; DISEASE SUSCEPTIBILITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HAPLOTYPES; HLA-DR2 ANTIGEN; HUMAN; INTERFERON TYPE II; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; LYMPHOTOXIN; MICE; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; POLYMORPHISM (GENETICS); SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR;

EID: 0028802606     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410380506     Document Type: Article

References (51)

1. HLA class II‐associated genetic susceptibility in multiple sclerosis: a critical evaluation
2. The role of genetic factors in multiple sclerosis susceptibility
3. Genetic factors in multiple sclerosis
4. Autoimmune diseases: the failure of self tolerance
5. Epidemiology and genetics of multiple sclerosis
6. Isolation of myelin basic protein‐reactive T cell lines from normal human blood
7. Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations
8. In healthy primates, circulating autoreactive T cells mediate autoimmune disease
9. Immunological aspects of demyelinating diseases
10. Cellular immune reactivity within the CNS
11. Hypothesis: a role for tumor necrosis factor in immune‐mediated demyelination and its relevance to multiple sclerosis
12. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
13. Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin
14. Map of the human MHC
15. The molecular cell biology of interferon‐γ and its receptor
16. Genetic variability at the human tumor necrosis factor loci
17. Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF‐β gene correlates with a variant amino acid in position 26 and a reduced level of TNF‐β production
18. A new restriction fragment length polymorphism of the human TNF‐B gene detected by Asp HI digest
19. An allelic polymorphism within the human tumor necrosis factor α promotor region is strongly associated with HLA A1, B8 and DR3 alleles
20. Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals
21. Myelin basic protein‐specific T lymphocyte repertoire in multiple sclerosis: complexity of response and dominance of nested epitopes due to recruitment of multiple T cell clones
22. Myelin basic proteins
23. Nonradioactive HLA class II typing using polymerase chain reaction and digoxygenin‐11‐2′‐3′‐dideoxyuridinetriphosphate labelled oligonucleotide probes
24. Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes
25. No independent association between a tumor necrosis factor‐α promoter region polymorphism and insulin‐dependent diabetes mellitus
26. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions
27. Lymphotoxin and tumor necrosis factor‐alpha production by myelin basic protein‐specific T cell clones correlates with encephalitogenicity
28. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis
29. Anti‐tumor necrosis factor therapy abrogates autoimmune demyelination
30. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?
31. Association between tumor necrosis factor‐α and disease progression in patients with multiple sclerosis
32. Cytokine secretion by multiple sclerosis monocytes. Relationship to disease activity
33. Tumor necrosis factor α production as a possible predictor of relapse in patients with multiple sclerosis
34. Cytokine production by peripheral blood monocytes/macrophages in multiple sclerosis patients
35. Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis
36. + T cell subset activation
37. Functional CD4 T cell subset interplay in an intact immune system
38. The major histocompatibility complex influences myelin basic protein 63‐88‐induced T cell cytokine profile and experimental autoimmune encephalomyelitis
39. Neurological autoimmune disease and the trimolecular complex of T‐lymphocytes
40. Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus: TNFB‐MHC haplotypes
41. Polymorphism of the tumor necrosis factor beta gene in multiple sclerosis and rheumatoid arthritis
42. Heritable major histocompatibility complex II‐associated differences in production of tumor necrosis factor α: relevance to genetic predisposition to systemic lupus erythematosus
43. Monocyte function in IDDM patients and healthy individuals
44. The effect of HLA and insulin‐dependent diabetes mellitus on the secretion levels of tumor necrosis factor alpha and beta and gamma interferon
45. Involvement of class II MHC molecules in the LPS‐induction of IL‐1/TNF secretions by human monocytes. Quantitative differences at the polymorphic level
46. Association between HLA‐DR2 and production of tumor necrosis factor α and interleukin 1 by mononuclear cells activated by lipopolysaccharide
47. Antigen processing gene polymorphisms in HLA‐DR2 multiple sclerosis
48. Tumor necrosis factor polymorphisms in multiple sclerosis: no additional association independent of HLA
49. MHC‐encoded TAP1 and TAP2 dimorphisms in multiple sclerosis
50. TAP1 and TAP2 polymorphism in multiple sclerosis patients
51. TAP2 gene polymorphism contributes to genetic susceptibility to multiple sclerosis