Imaging the Expression of Transfected Genes in Vivo

Cancer Research

Volumn 55, Issue 24, 1995, Pages 6126-6132

  Tjuvajev, Juri G ^a   Stockhammer, Gunther ^a   Desai, Revathi ^a   Uehara, Hisao ^a   Watanabe, Kyoichi ^a   Gansbacher, Bernd ^a   Blasberg, Ronald G ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CELL PROLIFERATION; GENE EXPRESSION; GENE MAPPING; GENETIC REGULATION; GENETIC SUSCEPTIBILITY; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; GLIOMA CELL; IMAGE ANALYSIS; MARKER GENE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ARABINOFURANOSYLURACIL; AUTORADIOGRAPHY; GANCICLOVIR; GENE EXPRESSION; GENE THERAPY; IDOXURIDINE; RATS; RNA, MESSENGER; THYMIDINE KINASE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0028802564     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Culver, K. W., and Blaese, R. M. Gene therapy for cancer. Trends Genet., 10: 174–178, 1994.
2. Clinical Protocol List. Cancer Gene Then., 1: 291, 1994.
3. Moolten, F. L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase gene: paradigm for a prospective cancer control strategy. Cancer Res., 46: 5276–5281, 1986.
4. Borrelli, E., Heyman, R., Hsi, M., and Evans, R. M. Targeting of an inducible toxic phenotype in animal cells. Proc. Natl. Acad. Sci. USA, 85: 7572–7576, 1988.
5. Moolten, F. L., and Wells, J. M. Curability of tumors bearing herpes thymidine kinase genes transfected by retroviral vectors. J. Natl. Cancer Inst., 82: 297–300, 1990.
6. Culver, K. W., Ram, Z., Wallbridge, S., Ishii, H., Oldfield, E. H., and Blaese, R. M. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science (Washington DC), 256: 1550–1552, 1992.
7. Prusoff, W. H. Synthesis and biological activities of iododeoxyuridine, an analog of thymidine. Biochim. Biophys. Acta, 32: 295–296, 1959.
8. MacCallum, F. O., and Juel-Jensen, B. E. Herpes simplex virus skin infection in man treated with idoxyuridine in dimethyl sulphoxide. Results of double-blind controlled trial. Br. Med. J., 2: 805–807, 1966.
9. Buckley, T. F., and MacCallum, F. O. Herpes simplex virus encephalitis treated with idoxuridine. Br. Med. J., 2: 419–420, 1967.
10. Smith, K. O., Galloway, K. S., Kennell, W. L., Ogilvie, K. K., and Radatus, B. K. A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2. Antimicrob. Agents Chemother., 22: 55–61, 1982.
11. Smee, D. F., Martin, J. C., Verheyden, J. P. H., and Matthews, T. R. Anti-herpesvirus activity of the acyclic nucleoside 9-(l, 3-dihydroxy-2-propoxymethyl)guanine. Antimicrob. Agents Chemother., 23: 676–682, 1983.
12. Field, A. K., Davies, M. E., De Witt, C., Perry, H. C., Liou, R., Germershausen, J., Karkas, J. D., Ashton, W. T., Johnston, D. B. R., and Tolman, R. 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Proc. Natl. Acad. Sci. USA, 80: 4139–4143, 1983.
13. Watanabe, K., Reichman, U., Hirota, K., Lopez, C., and Fox, J. Nucleosides 110 synthesis and antiherpes virus activity of some 2′-fluoro-2′-deoxy-arabinofuranosyI-pyrimidine nucleosides. J. Med. Chem., 22: 21–24, 1979.
14. 131I-labeled 5-iodo-2′-fluoro-2′-deoxy-1-β-D-arabino-furanosyl-uracil in herpes infected cells. J. Med. Virol., 22: 183–188, 1987.
15. Grant, A. J., Feinberg, A., Chou, T-C., Watanabe, K., Fox., J. J., and Philips, F. S. Incorporation of metabolites of 2′-fluoro-5-Iodo-1-β-D-arabinofuranosyl-cytosine into deoxyribonucleic acid of neoplastic and normal mammalian tissues. Biochem. Pharmacol., 31: 1103–1108, 1982.
16. Kong, X-B., Scheck, A., Price, R. W., Vidal, P. M., Fanucchi, M. P., Watanabe, K. A., Fox, J. J., and Chou, T-C. Incorporation and metabolism of 2′-fluoro-5-substituted arabinosyl pyrimidines and their selective inhibition of viral DNA synthesis in herpes simplex virus type 1 (HSV-1)-infected and mock-infected Vero cells. Antiviral Res., 10: 153–166, 1988.
17. Tjuvajev, J. G., Muraki, A., Ginos, J., Berk, J., Koutcher, J., Ballon, D., Beattie, B., Finn, R., Blasberg, R. Iododeoxyuridine uptake and retention as a measure of tumor growth. J. Nucl. Med., 34: 1152–1162, 1993.
18. Tjuvajev, J. G., Macapinlac, H. A., Daghighian, F., Scott, A. M., ginos, J. Z., Finn, R. D., Kothari, P., Desai, R., Zhang, Z., Beattie, B., Graham, M., Larson, S., and Biasberg, R. G. Imaging of brain tumor proliferative activity with iodine-131-iododeoxyuridine. J. Nucl. Med., 35: 1407–1417, 1994.
19. Saito, Y., Price, R. W., Rottenberg, D. A., Fox, J. J., Su, T-L., Watanabe, K. A., and Philips, F. A. Quantitative autoradiographic mapping of herpes simplex virus encephalitis with radiolabeled antiviral drug. Science (Washington DC), 217: 1151–1153, 1982.
20. Saito, Y., Rubenstein, R., Price, R. W., Fox, J. J., and Watanabe, K. A. Diagnostic imaging of herpes simplex virus encephalitis using radiolabeled antiviral drug: autoradiographic assessment in animal model. Ann. Neurol., 15: 548–558, 1984.
21. Price, R., Cardie, K., and Watanabe, K. The use of antiviral drugs to image herpes encephalitis. Cancer Res., 43: 3619–3627, 1983.
22. 14C]-5-iodo-(2′-fluoro-2′-deoxy-1-β-D-arabino-furanosyl)-cy-tosine in immunosuppressed patients with herpesvirus infections. Antimicrob. Agents Chemother., 27: 733–738, 1985.
23. King, D. H. Fluorinated pyrimidines: a new change for old drugs. Transplant. Proc., 25(Suppl. 3): 168–170, 1991.
24. Marshall, E. Drug trial death deemed unavoidable. Science (Washington DC), 264: 1530, 1994.
25. Abrams, D. N., Lee, Y. W., Mercer, J. R., Knaus, E. E., and Wiebe, L. I. Tumour uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models. DC. Radiolabelled 1-(2′-fluoro-2′-deoxy-βD-ribofuranosyl)uracil and 1-(2′-chloro-2′-deoxy-β-D-ribofuranosyl)uracil. Br. J. Radiol., 59: 263–268, 1986.
26. Ko, L., Koestner, A., and Wechsler, W. Morphological characterisation of nitrosurea-induced glioma cell lines and clones. Acta Neuropathol., 84: 529–541, 1980.
27. Gansbacher, B., Zier, K., Cronin, K., Hantzopolous, B., Bouchard, B., Houghton, A., Gilboa, E., and Golde, D. Retroviral gene transfer induced constitutive expression of interleukin-2 or interferon-γ in irradiated human melanoma cells. Blood, 80: 2817–2825, 1992.
28. Short, M. P., Choi, B. C., Lee, J. K., Malik, A., Breakfield, X. O., and Martuza, R. L. Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J. Neurosci. Res., 27: 427–433, 1990.
29. Blasberg, R. G., Groothuis, D., and Molnar, P. Application of quantitative autoradiographic measurements in experimental brain tumor models. Semin. Neurol., 1: 203–223, 1981.
30. Misra, H. K., Knaus, E. E., Wiebe, L. I., and Tyrrell, D. L. Synthesis of 131,I, I25I, 123I and 82Br labeled 5-halo-2′-deoxy-2′-fluoro-l-β-D-arabinofuranosyl-uracils. Appl. Radiat. Isot., 37: 901–905, 1986.
31. Iwashina, T., Tovell, D. R., Xu, L., Tyrrell, D. L., Knaus, E. E., and Wiebe, L. I. Synthesis and antiviral activity of IVFRU, a potential probe for the non-invasive diagnosis of herpes simplex encephalitis. Drug Des. Deliv., 3: 309–321, 1988.
32. Ram, Z., Walbridge, S., Heiss, J. D., Culver, K. W., Blaese, M., and Oldfield, E. H. In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors. J. Neurosurg., 80: 535–540, 1994.
33. Boviatsis, E. J., Park, J. S., Sena-Esteves, M., Kramm, C. M., Chase, M., Efird, J., Wei, M. X., Breakfield, X. O., and Chiocca, E. A. Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains intact thymidine kinase gene. Cancer Res., 54: 5745–5751, 1994.