Properties of the reversible, K+-competitive inhibitor of the gastric (H+/K+)-ATPase, SK&F 97574. I. In vitro activity

Biochemical Pharmacology

Volumn 50, Issue 10, 1995, Pages 1543-1549

  Pope, Andrew J ^d   Boehm, Mark K ^c   Leach, Colin ^c   Ife, Robert J ^c   Keeling, David ^a   Parsons, Michael E ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Molndal ^*  (Sweden)

^c UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^d NONE

Author keywords

competitive; gastric (H+ K+) ATPase; inhibitor; mechanism; membrane vesicle

Indexed keywords

2,3 DIHYDRO 6 METHYL 4 METHYLAMINO 1 (2 METHYLPHENYL)PYRROLO[2,3 C]QUINOLINE; 3 BUTYRYL 8 (2 HYDROXYETHOXY) 4 (2 METHYLANILINO)QUINOLINE; 8 BENZYLOXY 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 ACETONITRILE; 8 BENZYLOXY 3 CYANOMETHYL 1,2 DIMETHYLIMIDAZO[1,2 A]PYRIDINIUM IODIDE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE INHIBITOR; POTASSIUM ION; PROTON PUMP; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; MEMBRANE VESICLE; NONHUMAN; PH; PRIORITY JOURNAL; STOMACH MUCOSA; STOMACH PARIETAL CELL; SWINE;

ADENOSINE TRIPHOSPHATE; AMINOQUINOLINES; ANIMAL; BINDING, COMPETITIVE; DOGS; ENZYME INHIBITORS; H(+)-K(+)-EXCHANGING ATPASE; HYDROGEN-ION CONCENTRATION; KINETICS; NA(+)-K(+)-EXCHANGING ATPASE; POTASSIUM; STIMULATION, CHEMICAL; STOMACH; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0028802422     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02020-9     Document Type: Article

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