Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues

Gut

Volumn 36, Issue 2, 1995, Pages 259-267

  McKinnon, R A ^a   Burgess, W M ^a   Hall, P De La M ^a   Roberts Thomson, S J ^b   Gonzalez, F J ^c   McManus, M E ^d  

^a FLINDERS UNIVERSITY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cyrochromes P450; In situ hybridisation; Mutagen activation

Indexed keywords

ALPHA NAPHTHOFLAVONE; CYTOCHROME P450; MESSENGER RNA;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; INTESTINE CANCER; PRIORITY JOURNAL;

EID: 0028801964     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.36.2.259     Document Type: Article

References (48)

1. Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 1993; 12: 1-51.
2. Gonzalez FJ. The molecular biology of cytochrome P450s. Pharmacol Rev 1989; 40: 243-87.
3. Gonzalez FJ. Molecular genetics of the P-450 superfamily. Pharmac Ther 1990; 45: 1-38.
4. Shimada T, Martin MV, Pruess-Schwartz D, Marnett LJ, Guengerich FP. Roles of individual cytochrome P450 enzymes in the bioactivation of benzo[a]pyrene, 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Cancer Res 1989; 49: 6304-12.
5. NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc Natl Acad Sci USA 1989; 86: 462-5.
6. Shimada T, Iwasaki M, Martin MV, Guengerich FP. Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. Cancer Res 1989; 49: 3218-28.
7. 1. Proc Natl Acad Sci USA 1990; 87: 4790-3.
8. McKinnon RA, Burgess WM, Hall P de la M, Abdul-Aziz Z, McManus ME. Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids. Cancer Res 1992; 52: 2108s-13s.
9. Sugimura T, Sato, S Wakabayashi M. Mutagens/carcinogens in pyrolysates of amino acids and proteins in cooked foods: heterocyclic aromatic amines. In: Woo YT, Lai DY, Arcos JC, Argus MF, eds. Chemical induction of cancer, structural bases and biological mechanisms. New York: Academic Press, 1988:681-710.
10. Felton JS, Knize MG. Heterocyclic-amine mutagens/ carcinogens in foods. In: Cooper CS, Grover PL, eds. Chemical carcinogenesis and mutagenesis I, Handbook of Experimental Pharmacology. Vol 94/1. Berlin: Springer-Verlag, 1990: 471-502.
11. McManus ME, Burgess WM, Veronese ME, Huggett A, Quattrochi LC, Tukey RH. Metabolism of 2-acetylaminofluorene and benzopyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P450. Cancer Res 1990; 50: 3367-76.
12. McManus ME, Burgess W, Snyderwine E, Stupans I. Specificity of rabbit cytochrome P450 isozymes involved in the metabolic activation of the food derived mutagen 2-amino-3-methylimidazo [4,5-f]quinoline. Cancer Res 1988; 48: 4513-9.
13. McManus ME, Felton JS, Knize MG, Burgess WM, Roberts-Thomson S, Pond SM, et al. Activation of the food-derived mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by rabbit and human liver microsomes and purified forms of cytochrome P450. Carcinogenesis 1989; 10: 357-63.
14. Aoyama T, Gelboin HV, Gonzalez FJ. Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P450. Cancer Res 1990; 50: 6060-3.
15. Ames BN. Mutagenesis and carcinogenesis: endogenous and exogenous factors. Environ Mol Mutagen 1989; 16: S66-7.
16. Molowa DT, Schuetz EG, Wrighton SA, Watkins PB, Kremers P, Mendez-Picon G, et al. Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci USA 1986; 83: 8064-8.
17. Beaune PH, Umbenhauer DR, Bork RW, Lloyd RS, Guengerich FP. Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase. Proc Natl Acad Sci USA 1986; 83: 5311-5.
18. Gonzalez FJ, Schmid BJ, Umeno M, McBride OW, Hardwick JP, Meyer UA, et al. Human P450PCN1: Sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA 1988; 7: 79-86.
19. Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fisher V, et al. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. J Biol Chem 1989; 264: 10 388-95.
20. Schuetz JD, Molowa DT, Guzelian PS. Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver. Arch Biochem Biophys 1989; 274: 355-65.
21. Komori M, Nishio K, Ohi H, Kitada M, Kamataki T. Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P450. J Biochem 1989; 105: 161-3.
22. Bork RW, Muto T, Beaune P, Srivastava PK, Lloyd RS, Guengerich FP. Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. J Biol Chem 1989; 264: 910-9.
23. Wrighton SA, Brian WR, Sari M-A, Iwasaki M, Guengerich FP, Raucy JL, et al. Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3). Mol Pharmacol 1990; 38: 207-13.
24. Wrighton SA, Ring BJ, Watkins PB, Vandenbranden M. Identification of a polymorphically expressed member of the human cytochrome P-450III family. Mol Pharmacol 1989; 36: 97-105.
25. Komori M, Nishio M, Fujitani T, Ohi H, Kitada M, Mima S, et al. Isolation of a new human fetal liver cDNA clone: Evidence for a limited number of forms of cytochrome P450 in human fetal livers. Arch Biochem Biophys 1989; 272: 219-25.
26. Watkins PB, Wrighton SA, Schuetz EG, Molowa DT, Guzelian PS. Identification of Glucocorticoid-inducible Cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest 1987; 80: 1029-36.
27. De Waziers I, Cugnenc PH, Yang CS, Leroux JP, Beaune PH. Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J Pharmacol Exp Therap 1990; 253: 387-94.
28. Murray GI, Barnes TS, Sewell HF, Ewen SWB, Melvin WT, Burke MD. The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450. Br J Clin Pharmac 1988; 25: 465-75.
29. Kolars JC, Schmiedlin-Ren P, Schuetz JD, Fang C, Watkins PB. Identification of Rifampicin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. J Clin Invest 1992; 90: 1871-8.
30. Chomczynski P, Saachi N. Single-step method of RNA isolation by acid guandinium thiocyanate-phenolchloroform extraction. Anal Biochem 1987; 162: 156-9.
31. Aviv H, Leder P. Purification of biological active globin messenger RNA by chromatography on oligothymidylic acid cellulose. Proc Natl Acad Sci USA 1972; 69: 1408-12.
32. Lehrach M, Diamond D, Wozney JM, Boedtker H. RNA molecular weight determinations by gel electrophoresis under denaturing conditions: a critical reexamination. Biochemistry 1977; 16: 4743-51.
33. McKinnon RA, Hall P de la M, Quattrochi LC, Tukey RH, McManus ME. Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization. Hepatology 1991; 14: 848-56.
34. Zuber MX, Simpson ER, Waterman MR. Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS1) cells. Science 1986; 234: 1258-61.
35. Laemmli UK. Cleavage of structural proteins during the assembly of a bacteriophage T4. Nature 1970; 227: 680-5.
36. Maron DM, Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat Res 1983; 113: 173-215.
37. McManus ME, McKinnon RA. Measurement of cytochrome P450 activation of xenobiotics using the Ames/Salmonella test. Methods Enzymol 1991; 206: 501-9.
38. Murray GI, Barnes TS, Sewell HF, Ewen SWB, Melvin WT, Shaw PM, Fowler J, Burke MD. Cytochrome P-450 localization in normal human adult and fetal liver by immunocytochemistry using a monoclonal antibody against human cytochrome P-450. Histochem J 1987; 19: 537-45.
39. Hassett C, Luchtel DL, Omiecinski CJ. Hepatic expression of rat P450 mRNA assessed by in situ hybridization to oligomer probes. DNA 1989; 8: 29-37.
40. Baron J, Redick JA, Guengerich FP. An immunohistochemical study on the localizations and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochrome P450 within livers of untreated rats. J Biol Chem 1981; 256: 5931-7.
41. Baron J, Redick JA, Guengerich FP. Effects of 3-methylcholanthrene, β-naphthoflavone, and phenobarbital on the 3-methylcholanthrene-inducible isozyme of cytochrome P450 within centrilobular, midzonal and periportal hepatocytes. J Biol Chem 1982; 257: 953-7.
42. Ohnishi K, Mishima A, Okuda K. Immunofluorescence of phenobarbital inducible cytochrome P-450 in the hepatic lobule of normal and phenobarbital-treated rats. Hapatology 1982; 2: 849-55.
43. Ingelman-Sundberg M, Johansson I, Penttila KE, Glaumann H, Lindros KO. Centrilobular expression of ethanol-inducible cytochrome P450 (IIE1) in rat liver. Biochem Biophys Res Commun 1988; 157: 55-60.
44. Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber CS. The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology 1989; 10: 437-46.
45. McManus ME, Hall PM, Stupans I, Brennan J, Burgess W, Robson R, et al. Immunohistochemical localization and quantitation of NADPH-cytochrome P450 reductase in human liver. Mol Pharmacol 1987; 32: 189-94.
46. Stricker BHC, Spoelstra P. Drug-induced hepatic injury. Amsterdam: Elsevier, 1985.
47. Peters WHM, Boon CEW, Roelofs HMJ, Wobbes T, Nagengast FM, Kremers PG. Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa. Gastroenterology 1992; 103: 448-55.
48. Peters WHM, Kremers PG. Cytochromes P-450 in the intestinal mucosa of man. Biochem Pharmacol 1989; 38: 1535-8.