Physical dissociation of the TCR-CD3 complex accompanies receptor ligation

Journal of Experimental Medicine

Volumn 182, Issue 6, 1995, Pages 1997-2006

  Kishimoto, Hidehiro ^a,e   Kubo, Ralph T ^b   Yorifuji, Hiroshi ^c   Nakayama, Toshinori ^a   Asano, Yoshihiro ^d   Tada, Tomio ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b CYTEL CORPORATION   (United States)

^c NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; IMMUNOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ANIMAL; ANTIGENS, CD2; ANTIGENS, CD3; CALCIUM; DOWN-REGULATION; ENTEROTOXINS; IMMUNOHISTOCHEMISTRY; IONOMYCIN; IONOPHORES; LIGANDS; MACROMOLECULAR SYSTEMS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHOTYROSINE; RECEPTOR AGGREGATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES;

EID: 0028800991     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.182.6.1997     Document Type: Article

References (44)

1. Samelson, L.E., J.B. Harford, and R.D. Klausner. 1985. Identification of the components of the murine T cell antigen receptor complex. Cell. 43: 223-231.
2. Koning, F., W.L. Maloy, and J.E. Coligan. 1990. The implication of subunit interactions for the structure of the T cell receptor-CD3 complex. Eur.J. Immunol. 20: 299-305.
3. Blumberg, R.S., S. Ley, J. Sancho, N. Lonberg, E. Lasy, F. McDermott, V. Schad, J.L. Greenstein, and C. Terhorst. 1990. Structure of T-cell antigen receptor: evidence for two CD3e subunits in the T-cell receptor-CD3 complex. Proc. Natl. Acad. Sri. USA. 87: 7220-7224.
4. De La Herra, A., U. Muller, C. Olsson, S. Isaaz, and A. Tunnacliffe. 1991. Structure of the T cell antigen receptor (TCR): two CD3e subunits in a functional TCR/CD3 complex. J. Exp. Med. 173: 7-17.
5. Wegener, A.-M.K., A.H. Letoumeur, T. Brocker, F. Luton, and B. Malissen. 1992. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell. 68: 83-95.
6. Letourneur, F., and R.D. Klausner. 1992. Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3e. Science (Wash. DC). 255: 79-82.
7. Weissman, A.M., M. Baniyash, D. Hou, L.E. Samelson, W.H. Burgess, and R.D. Klausner. 1988. Molecular cloning of the zeta chain of the T cell antigen receptor. Science (Wash. DC). 239: 1018-1021.
8. Jin, Y.J., L.K. Clayton, F.D. Howard, S. Koyasu, M. Sieh, R. Steinbrich, G.E. Tarr, and E.L. Reinherz. 1990. Molecular cloning of the CD3t] subunit identifies a CD3£-related product in thymus-derived cells. Proc. Natl. Acad. Sci. USA. 87: 3319-3323.
9. Kuster, H., H. Tompson, and J.P. Kinet. 1990. Characterization and expression of the gene for human Fc receptor y subunit. J. Biol. Chem. 265: 6448-6452.
10. Minami, Y., A.E. Weissman, L.E. Samelson, and R.D. Klausner. 1987. Building a multichain receptor: synthesis, degradation and assembly of the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA. 84: 2688-2692.
11. Kearse, K.P., J.L. Roberts, T.I. Munitz, D.L. Wiest, T. Nakayama, and A. Singer. 1994. Developmental regulation of a (3 T cell antigen receptor expression results from differential stability of nascent TCRa proteins within the endoplasmic reticulum of immature and mature T cells. EMBO (Eur. Mol. Biol. Organ.)J. 13: 4504-4514.
12. Finkel, T.H., J.C. Cambier, R.T. Kubo, W.K. Bom, P. Marrack, and J.P. Kappler. 1989. The thymus has two functionally distinct populations of immature a(3+ T cells: one population as deleted by ligation of ot(3TCR. Cell. 58: 1047-1054.
13. Finkel, T.H., P. Marrack, J.P. Kapplar, R.T. Kubo, and J.C. Cambier. 1989. a(3TCR and CD3 transduce different signals in immature T cells: implications for selection and tolerance. J. Immunol. 142: 3006-3012.
14. Newell, M.K., L.J. Haughn, C.R. Maroun, and M.H. Julius. 1990. Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature (Lond.). 347: 286-288.
15. Haughn, L., S. Gratton, L. Caron, R.-P. Sekaly, A. Veillete, and M. Julius. 1992. Association of tyrosine kinase p561ck with CD4 inhibits the induction of growth through the a(3 T-cell receptor. Nature (Lond.). 358: 328-331.
16. Tada, T., F.-Y. Hu, H. Kishimoto, M. Furutani-Seiki, and Y. Asano. 1991. Molecular events in the T cell-mediated suppression of immune response. Ann. NY Acad. Sci. 636:2027.
17. Kisielow, P., H. Bluthmann, U.D. Staerz, M. Steinmetz, and H. Von Boehmer. 1988. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature (Lond.). 333: 742-746.
18. Kappler, J., J. White, D. Wegmann, E. Mustein, and P. Marrack. 1982. Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas. Proc. Natl. Acad. Sci. USA. 79: 3604-3607.
19. Sano, K., I. Fujisawa, R. Abe, Y. Asano, and T. Tada. 1987. MHC-restricted minimal regulatory circuit initiated by class II-autoreactive T cell clone. J. Exp. Med. 165: 1284-1295.
20. Nakayama, T., R.T. Kubo, H. Kishimoto, Y. Asano, and T. Tada. 1989. Biochemical identification of I-J as a novel dimeric surface molecule on mouse helper and suppressor T cell clones. Int. Immunol. 1: 50-58.
21. Kubo, R.T., W. Bom, J.W. Kappler, P. Marrack, and M. Pigeon. 1989. Characterization of a monoclonal antibody which detects all murine a/p T cell receptors. J. Immunol. 142: 2736-2742.
22. Staerz, U.D., H.-G. Rammensee, J.D. Benedetto, and M.J. Bevan. 1985. Characterization of a murine monoclonal antibody specific for an allotypic determination on T cell antigen receptor. J. Immunol. 134: 3994-4000.
23. Leo, O., M. Foo, D.H. Sachs, L.E. Samelson, and J.A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sri. USA. 83: 767-771.
24. Havran, W.L., M. Poenie, J. Kimura, R. Tsien, A. Weiss, and J.P. Allison. 1987. Expression and function ofthd CD3antigen receptor on murine CD4+8+ thymocytes. Nature (Lond.). 330: 170-173.
25. Yagita, H., J. Nakamura, J. Asakawa, H. Matsuda, S. Tansyo, Y. Ligo, and K. Okumura. 1989. CD2 expression in murine B cell lineage. Int. Immunol. 1: 94-98.
26. Born, W., C. Miles, J. White, R. O’Brien, J.H. Freed, P. Marrack, J.P. Kappler, and R.T. Kubo. 1987. Peptide sequences of T cell receptor δ and γ chains are identical to predicted X and y proteins. Nature (Lond.). 330: 572-574.
27. Becker, M.L.B., R. Near, M. Mudgett-Hunter, M. Margolies, R.T. Kubo, J. Kaye, and S.M. Hedreck. 1989. Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell. 58: 911-921.
28. Rozdzial, M.M., R.T. Kubo, S.L. Turner, and T.H. Finkel. 1994. Developmental regulation of the TCR £-chain: differential expression and tyrosine phosphorylation of the TCR £-chain in resting immature and mature T lymphocytes. J. Immunol. 153: 1563-1580.
29. Laemmli, U.K. 1970. Cleavage of stmctural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227: 680-685.
30. Yorifuji, H., and N. Hirokawa. 1989. Cytoskeletal architecture of neuromuscular junction: localization of vinclin. J. Electron Microsc. Tech. 12: 160-171.
31. Saito, T., A. Weiss, J. Miller, M.A. Norcross, and R.N. Germain. 1987. Specific antigen-la activation of transfected human T cells expressing murine Ti aP-human T3 receptor complexes. Nature (Lond.). 325: 125-130.
32. Meuer, S.C., K.A. Fitzgerald, R.E. Hussey, J.C. Hodgdon, S.F. Schlossman, and E.L. Reinherz. 1983. Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J. Exp. Med. 157: 705-719.
33. June, C.H., M.C. Fletcher, J.A. Ledbetter, and L.E. Samelson. 1990. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J. Immunol. 144: 1591-1599.
34. Ullman, K.S., J.P. Northrop, C.L. Verweji, and G.R. Crabtree. 1990. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu. Rev. Immunol. 8: 421-452.
35. Levelt, C.N., P. Mombaers, A. Iglesias, S. Tonegawa, and K. Eichmann. 1993. Restoration of early thymocyte differentiation in T cell receptor-P chain-deficient mice by transmembrane signaling through CD3e. Proc. Natl. Acad. Sci. USA. 90: 11401-11405.
36. Shinkai, Y., and F.D. Alt. 1994. CD3e-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG2_/-mice in the absence of TCR P chain expression. Int. Immunol. 6: 995-1001.
37. Shinkai, Y., G. Rathubun, K.-P. Lam, U.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, and F.W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68: 855-867.
38. Mombaerts, P., J. Iacomini, R.S. Johnson, K. Herrup, S. Tonegawa, and V.E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
39. Mombaerts, P., A.R. Clarke, M.A. Rudnicki, J. Iacomini, S. Itohara, J.J. Lafaolle, L. Wang, Y. Ichikawa, R. Jaenisch, M.L. Hooper, and S. Tonegawa. 1992. Mutation in T-cell antigen receptor genes a and P block thymocyte development at different stages. Nature (Lond.). 360: 225-231.
40. Shinkai, Y., S. Koyasu, K. Nakayama, K.M. Murphy, D.Y. Loh, E.L. Reinhertz, and F.W. Alt. 1993. Restoration of T cell development in RAG-2 deficient mice by functional TCR transgenes. Science (Wash. DC). 259:822.
41. Mizoguchi, H., J.J. O’Shea, D.L. Longo, C.M. Loeffler, D.W. McVicar, and A.C. Ochoa. 1992. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science (Wash. DC). 258: 1795-1798.
42. Aoe, T., Y. Okamoto, and T. Saito. 1995. Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J. Exp. Med. 181: 1881-1886.
43. Sloan-Lancaster, J., A.S. Shaw, J.B. Rothbard, and P.M. Allen. 1994. Partial T cell signaling: altered phospho-£ and lack of Zap70 recruitment in APL-induced T cell anergy. Cell. 79: 913-922.
44. Madrenas, J., R.L. Wange, J.L. Wang, N. Isakov, L.E. Samelson, and R.N. Germain. 1995. ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science (Wash. DC). 267: 515-518.