CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells

Genes and Development

Volumn 9, Issue 22, 1995, Pages 2780-2794

  Stuart, David ^a   Wittenberg, Curt ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cdc28 kinase; cell cycle; CLN; Cyclin; Start; transcription

Indexed keywords

CYCLINE; PHOSPHOTRANSFERASE;

ARTICLE; CELL CYCLE; GENE ACTIVATION; GENETIC TRANSCRIPTION; KINETICS; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; YEAST;

SACCHAROMYCETALES;

EID: 0028800378     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.9.22.2780     Document Type: Article

References (53)

1. Amon, A., M. Tyers, B. Futcher, and K. Nasmyth. 1993. Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell 74: 993-1007.
2. Andrews, B.J. and I. Herskowitz. 1989. Identification of a DNA binding factor involved in cell-cycle control of the yeast HO gene. Cell 57: 21-29.
3. _. 1990. Regulation of cell cycle-dependent gene expression in yeast. J. Biol. Chem. 264: 14057-14060.
4. 1 cyclin expression by cyclic AMP in budding yeast. Nature 371: 339-342.
5. Breeden, L. 1988. Cell cycle-regulated promoters in budding yeast. Trends Genet. 4: 249-253.
6. Breeden, L. and K. Nasmyth. 1985. Regulation of the yeast HO gene. Cold Spring Harbor Symp. Quant. Biol. 50: 643-650.
7. _. 1987. Cell cycle control of the yeast HO gene: cis- and trans-acting regulators. Cell 48: 389-397.
8. Breeden, L. and G. Mikesell. 1991. Cell cycle-specific expression of the SWI4 transcription factor is required for the cell cycle regulation of HO transcription. Genes &. Dev. 5: 1183-1190.
9. Cross, F. 1988. DAF1, a mutant gene affecting size control, pheromone arrest and cell cycle kinetics of S. cerevisiae. Mol. Cell Biol. 8: 4675-4684.
10. _. 1990. Cell-cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-I arrest and is independent of the mating pheromone signal. Mol. Cell. Biol. 10: 6482-6490.
11. Cross, F.R. and A.H. Tinkelenberg. 1991. A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle. Cell 65: 875-883.
12. Cross, F.R. and C.M. Blake. 1993. The yeast Cln3 protein is an unstable activator of Cdc28. Mol Cell Biol. 13: 3266-3271.
13. Cross, F.R., M. Hoek, J.D. McKinney, and A.H. Tinkelenberg. 1994. Role of Swi4 in cell cycle regulation of CLN2 expression. Mol Cell. Biol. 14: 4779-4787.
14. Deshaies, R.J., V. Chau, and M. Kirschner. 1995. Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J. 14:303-312.
15. Dirick, L. and K. Nasmyth. 1991. Positive feedback in the activation of G1 cyclins in yeast. Nature 351: 754-757.
16. Dirick, L., T. Moll, H. Auer, and K. Nasmyth. 1992. A central role for swi6 in modulating cell cycle Start-specific transcription in yeast. Nature 357: 508-513.
17. Epstein, C.B. and F.R. Cross. 1992. CLB5: A novel B cyclin from budding yeast with a role in S phase. Genes & Dev. 6: 1695-1706.
18. Frohlich, K.U., H.-W. Fries, M. Rudiger, R. Erdman, D. Botstein, and D. Mecke. 1991. Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression. J. Cell Biol. 114: 443-453.
19. Hadwiger, J.A., C. Wittenberg, M.A. de Barros Lopes, H.E. Richardson, and S.I. Reed. 1989. A family of cyclin homologs that control G1 phase in yeast. Proc. Nat. Acad. Sci. 86: 6255-6259.
20. Hartwell, L.H., J. Culotti, J.R. Pringle, and B.J. Reid. 1974. Genetic control of the cell division cycle in yeast. Science 183: 46-51.
21. Johnston, L.H. and N.F. Lowndes. 1992. Cell cycle control of DNA synthesis in budding yeast. Nucleic Acids Res. 20: 2403-2410.
22. Koch, C. and K. Nasmyth. 1994. Cell cycle regulated transcription in yeast. Curr. Opin. Cell Biol. 6: 451-459.
23. Koch, C., T. Moll, M. Neuberg, H. Ahorn, and K. Nasmyth. 1993. A role for transcription factors Mbp1 and Swi4 in progression from G1 to S phase. Science 261: 1551-1557.
24. Kuhne, C. and P. Linder. 1993. A pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle. EMBO J. 12: 3437-3447.
25. Lew, D.J., N.J. Marini, and S.I. Reed. 1992. Different G1 cyclins control the timing of cell cycle commitment in mother and daughter cells in the budding yeast Saccharomyces cerevisiae. Cell 69: 317-327.
26. Lorincz, A. and B.L.A. Carter. 1979. Control of cell size at bud initiation in Saccharomyces cerevisiae. J. Gen. Microbiol. 113: 287-295.
27. Lowndes, N.F., A.L. Johnson, and L.H. Johnston. 1991. Coordination of expression of DNA synthesis genes in budding yeast by a cell cycle regulated trans factor. Nature 350: 247-248.
28. Lowndes, N.F., A.L. Johnson, L. Breeden, and L.H. Johnston. 1992. SWI6 protein is required for transcription of the periodically expressed DNS synthesis genes in budding yeast. Nature 357: 505-508.
29. Measday, V., L. Moore, J. Ogas, M. Tyers, and B. Andrews. 1994. The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: A cell cycle regulator in yeast. Science 266: 1391-1395.
30. + gene of S. cerevisiae tethers cell division to cell size and is a cyclin homolog. EMBO J. 7: 4335-4346.
31. Nasmyth, K. 1985. A repetitive DNA sequence that confers cell-cycle START (CDC28-dependent transcription of the HO gene in yeast. Cell 42: 225-235.
32. _. 1993. Control of the yeast cell cycle by the Cdc28 protein kinase. Gurr. Opin. Cell Biol. 5: 166-179.
33. Nasmyth, K. and L. Dirick. 1991. The role of SWI4 and SWI6 in the activity of the G1 cyclins in yeast. Cell 66: 995-1013.
34. Ogas, J., B. Andrews, and I. Herskowitz. 1991. Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SW14, a positive regulator of G1-specific transcription. Cell 66: 1015-1026.
35. Price, C., K. Nasmyth, and T. Schuster. 1991. A general approach to the isolation of cell cycle regulated genes in the budding yeast saccharomyces cerevisiae. J. Mol Biol. 218: 543-556.
36. Pringle, J.R, and L.H. Hartwell. 1981. The Saccharomyces cerevisiae cell cycle. In The molecular biology of the yeast Saccharomyces cerevisiae (ed. J. Strathern, E.W. Jones, and J.R. Broach), pp. 97-142. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
37. Reed, S.I. 1992. The role of p34 kinases in the G1 to S-phase transition. Annu. Rev. Cell Biol. 8: 529-561.
38. Richardson, H.E., C. Wittenberg, F.R. Cross, and S.I. Reed. 1989. An essential G1 function for cyclin-like proteins in yeast. Cell 59: 1127-1133.
39. Richardson, H.E., D.J. Lew, M. Henze, K. Sugimoto, and S.I. Reed. 1992. Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2. Genes & Dev. 6: 2021-2034.
40. Rose, M.D., F. Winston, and P. Heiter. 1990. Methods in yeast genetics: A laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
41. Rothstein, R. 1983. One-step gene disruption in yeast. Methods Enzymol. 101:202-211.
42. Salama, S.R., K.B. Hendricks, and J. Thorner. 1994. G1 cyclin degradation: The PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover. Mol. Cell. Biol. 14: 7953-7966.
43. Schwob, E. and K. Nasmyth. 1993. CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes &. Dev. 7: 1160-1175.
44. Schwob, E., T. Boehm, M.D. Mendenhall, and K. Nasmyth. 1994. The B-type cyclin kinase inhibitor p40SICI controls the G1/S transition in Saccharomyces cerevisiae. Cell 79: 233-244.
45. Stuart, D. and C. Wittenberg. 1994. Cell cycle-dependent transcription of CLN2 is conferred by multiple distinct cis-acting regulatory elements. Mol Cell Biol. 14: 4788-4801.
46. Sudbery, P.E., A.R. Goodey, and B.L.A. Carter. 1980. Genes which control cell proliferation in the yeast Saccharomyces cerevisiae. Nature 288: 401-404.
47. Surana, U., H. Robitsch, C. Price, T. Shuster, I. Fitch, A.B. Futcher, and K. Nasmyth. 1991. The role of CDC28 and cyclins during mitosis in the budding yeast S. ceievisiae. Cell 65: 145-161.
48. Taba, M.R.M., I. Muroff, D. Lydall, G. Tebb, and K. Nasmyth. 1991. Changes in a SWI4,6-DNA-binding complex occur at the time of HO gene activation in yeast. Genes & Dev. 5: 2000-2013.
49. Tokiwa, G., M. Tyers, T. Volpe, and B. Futcher. 1994. Inhibition of G1 cyclin activity by the Ras/cAMP pathway in yeast. Nature 371: 342-345.
50. Tyers, M., G. Tokiwa, R. Nash, and B. Futcher. 1992. The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J. 11: 1773-1784.
51. Tyers, M., G. Tokiwa, and B. Futcher. 1993. Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J. 12:1955-1968.
52. Valdivieso, M.H., K. Sugimoto, K.Y. Jahng, P.M.B. Fernandes, and C. Wittenberg. 1993. FAR1 is required for post-transcriptional regulation of CLN2 gene expression in response to mating pheromone. Mol. Cell. Biol. 13: 1013-1022.
53. Wittenberg, C., K. Sugimoto, and S.I. Reed. 1990. G1-specific cyclins of S. cerevisiae: Cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase. Cell 62: 225-237.