Synthetic and Structure/Activity Studies on Acid-Substituted 2-Arylphenols: Discovery of 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]-propoxy]phenoxy]benzoic Acid, a High-Affinity Leukotriene B4 Receptor Antagonist

Journal of Medicinal Chemistry

Volumn 38, Issue 22, 1995, Pages 4411-4432

  Sawyer, J Scott ^a   Bach, Nicholas J ^a   Baker, S Richard ^a   Baldwin, Ronald F ^a   Borromeo, Peter S ^a   Cockerham, Sandra L ^a   Fleisch, Jerome H ^a   Floreancig, Paul ^a   Froelich, Larry L ^a   Jackson, William T ^a   Marder, Philip ^a   Palkowitz, Jayne A ^a   Roman, Carlos R ^a   Saussy, David L ^b   Schmittling, Elisabeth A ^a   Silbaugh, Steven A ^a   Spaethe, Stephen M ^a   Stengel, Peter W ^a   Sofia, Michael J ^c  

^a ELI LILLY AND COMPANY   (United States)

^b GLAXOSMITHKLINE   (United States)

^c Transcell Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 PROPYL 3 [3 [2 ETHYL 4 (4 FLUOROPHENYL) 5 HYDROXYPHENOXY]PROPOXY]PHENOXY]BENZOIC ACID; 5 (3 CARBOXYBENZOYL) 2 [6 (4 METHOXYPHENYL) 5 HEXENYLOXY]HYDROCINNAMIC ACID; 5 ETHYL 2 HYDROXY 4 [6 METHYL 6 (1H TETRAZOL 5 YL)HEPTYLOXY]ACETOPHENONE; 7 [3 (4 ACETYL 3 METHOXY 2 PROPYLPHENOXY)PROPOXY] 3,4 DIHYDRO 8 PROPYL 2H 1 BENZOPYRAN 2 CARBOXYLIC ACID; 7 [3 [2 CYCLOPROPYLMETHYL 3 METHOXY 4 [(METHYLAMINO)CARBONYL]PHENOXY]PROPOXY] 3,4 DIHYDRO 8 PROPYL 2H 1 BENZOPYRAN 2 PROPANOIC ACID; CELL SURFACE RECEPTOR; LEUKOTRIENE B4; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE B4 RECEPTOR ANTAGONIST; LEUKOTRIENE D4; LY 210073; MOXILUBANT MALEATE; RG 14893; UNCLASSIFIED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; AMINO ACID SUBSTITUTION; ARTICLE; CHEMOKINESIS; CHEMOTAXIS; DOSE RESPONSE; ENTERITIS; GUINEA PIG; HUMAN; PSORIASIS; RHEUMATOID ARTHRITIS; STRUCTURE ACTIVITY RELATION;

AIRWAY OBSTRUCTION; ANIMAL; BENZOATES; GUINEA PIGS; HUMAN; LEUKOTRIENE B4; LUNG; NEUTROPHILS; PHENOLS; RECEPTORS, LEUKOTRIENE B4; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 0028799247     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00022a006     Document Type: Article

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