Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Nature Medicine

Volumn 1, Issue 12, 1995, Pages 1311-1314

  Frederich, Robert C ^a   Hamann, Andreas ^a   Anderson, Stephen ^a   Löllmann, Bettina ^a   Lowell, Bradford B ^a   Flier, Jeffrey S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROTEIN;

ADIPOCYTE; ANIMAL EXPERIMENT; ARTICLE; BODY FAT; BODY WEIGHT; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMAL; BODY WEIGHT; DIETARY FATS; FEMALE; LEPTIN; LIPIDS; MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OBESITY; PROTEINS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028793697     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1295-1311     Document Type: Article

References (21)

1. Hill, J. O. et al. Nutrient balance in humans: Effects of diet composition. Am. J. clin. Nutr 54, 10-17 (1991).
2. West, D. B., Boozer, C. N., Moody, D. L., & Atkinson, R. L. Dietary obesity in nine inbred mouse strains. A J. Physiol 262, R1025-R1032 (1992)
3. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human ho-mologue. Natur 372, 425-432 (1994).
4. Halass, J. L. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Scienc 269, 543-546 (1995).
5. Frederich, R. C. et al. Expression of ob mRNA and its encoded protein in rodents: Impact of nutrition and obesity. J. clin. Invest 96, 1658-1663 (1995).
6. Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R. & Burn, P. Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks. Scienc 269, 546-549 (1995).
7. Pelleymounter, M. A. et al. Effects of the obes gene product on body weight regulation in ob/o mice. Scienc 269, 540-543 (1995).
8. Maffei, M. et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the d locus. Proc. natn. Acad. Sci. U. S. A 92, 6957-6960 (1995).
9. Ogawa, Y. et al. Molecular cloning of rat obes cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa rats. J. clin. Invest 96, 1647-1652 (1995).
10. Mizuno, T., Funabashi, T., Kleopoulos, S. & Mobb, C. V. Elevated expression of (obese ob/ob gene product in adipose tissue, and impaired induction by insulin of Jun-B mRNA in liver in genetically obese yellow mice. Endocr. Soc. Abstr p. 174 (1995)
11. Funahashi, T. et al. Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochem. biophys. Res. Commun 211, 469-475 (1995).
12. Lowell, B. B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Natur 366, 740-742 (1993).
13. Hamann, A. Characterization of the insulin resistant state in transgenic mice with brown fat deficiency. Diabete 44, 1266-1273 (1995).
14. Weigle, D. S. Appetite and the regulation of body composition, FASEB J 8, 302-310 (1994).
15. Dubuc, P. U. Basal corticosterone levels of young ob/o mice. Horm. Metab. Res 9, 95-97 (1977).
16. Hamann, A., Flier, J. S. St Lowell, B. B. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes and hyperlipidemia. Endocrinolog (in the press).
17. Considine, R. V. et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J. clin. Invest 95, 2986-2988 (1995).
18. Salmon, D. M. V. Flatt, J. P. Effect of dietary fat content on the incidence of obesity among ad libitu fed mice. Int J. Obesit 9, 443-449 (1985).
19. Friedman, J. M. St Leibel, R. L. Tackling a weighty problem. Cell 69, 217-220 (1992).
20. Bouchard. C. (ed. ) The Genetics of Obesit (CRC Press Inc., Boca Raton, Florida, 1994).
21. Hill, J. O., Lin, D., Yakubu, F. St Peters, J. C. Development of dietary obesity in rats: Influence of amount and composition of dietary fat. Int. J. Obes. 16, 321-333 (1992).