SCOPUS 정보 검색 플랫폼

Volumn 5, Issue 22, 1995, Pages 2717-2720

6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties

Author keywords

[No Author keywords available]

Indexed keywords

3',6 DINITROFLAVONE; 4',6 DINITROFLAVONE; ANXIOLYTIC AGENT; BENZODIAZEPINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; COW; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOUSE; NONHUMAN; SYNAPTOSOME;

EID: 0028792457 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/0960-894X(95)00464-5 Document Type: Article

Times cited : (38)

References (12)

2
- 0027976019
- Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora Coerulea
- (1994) Pharmacology Biochemistry and Behavior , vol.47 , pp. 1
- Wolfman¹ Viola² Paladini³ Dajas⁴ Medina⁵

5
- 84916558519
- Marder, M.; Viola, H.; Wasowski, C.; Wolfman, C.; Waterman, P. G.; Medina, J. H.; Paladini, A. C. submitted to J. Med. Chem.

7
- 0028104631
- (1994) J. Med. Chem. , vol.37 , pp. 3353
- Cushman¹ Zhu² Geahlen³ Kraker⁴

8
- 84916558517
- 3H-FNZ was used. Non specific binding was determined in parallel incubations in the presence of 3 μM FNZ, and represented 5–15% of total. The assays were terminated by filtration under vacuum though Whatman GF/A glass-fiber filters, and three washes with 3 mL each of incubation medium. Filters were dried and counted after the addition of 5 mL of 2,5-diphenyloxazole/xylene as scintillation fluid.

10
- 84916558516
- The animals used in the pharmacological test were male Swiss mice from our breeding stock, weighing 28–35 g. They were placed in groups of ten with free access to water and food, and maintained on 12h/12h day/night cycle. In all the tests the mice were i. p. injected with VEH or a solution of the drug, 15 min before the assay.The elevated plus-maze set-up consisted of a maze of two open arms, 25 × 5 cm, crossed by two closed arms of the same dimensions, with free access to all arms from the crossing point. The closed arms had walls 35 cm high all around. The maze was suspended 50 cm from the room floor. Mice were placed on the central part of the cross facing an open arm. The number of entries and the time spent going into open and closed arms were counted during 5 min. A selective increase in the parameters corresponding to open arms reveals an anxiolytic effect. The total exploratory activity (number of entries in both arms) was also determined.

11
- 0022374863
- Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
- (1986) Journal of Neuroscience Methods , vol.14 , pp. 149
- Pellow¹ Chopin² Fil³ Briley⁴

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.