BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice

Blood

Volumn 86, Issue 12, 1995, Pages 4603-4611

  Voncken, Jan Willem ^a   Kaartinen, Vesa ^a   Pattengale, Paul K ^a   Germeraad, Wilfred T V ^a   Groffen, John ^a   Heisterkamp, Nora ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; MESSENGER RNA; METALLOTHIONEIN; ONCOPROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LEUKEMIA; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; LEUKEMOGENESIS; NONHUMAN; PRIORITY JOURNAL; RNA TRANSCRIPTION; TRANSGENIC MOUSE;

EID: 0028789703     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v86.12.4603.bloodjournal86124603     Document Type: Article

References (53)

1. Nowell PC, Hungerford DA: A minute chromosome in human chronic granulocytic leukemia. Science 132:1497, 1960
2. De Klein A, Geurts van Kessel A, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp N, Groffen J, Stephenson JR: A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia. Nature 300:765, 1982
3. Rowley JD: A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and giemsa staining. Nature 243:290, 1973
4. Sandberg AA: Chromosome instability syndromes, in The Chromosomes in Human Cancer and Leukemia (ed 2). New York, NY, Elsevier, 1990, p 185
5. Priest JR, Robinson LL, McKenna RW, Lindquist LL, Warkentin PI, LeBien TW, Woods WG, Kersey JH, Coccia PF, Nesbit ME Jr: Philadelphia chromosome positive childhood acute lymphoblastic leukemia. Blood 56:15, 1980
6. Van Etten RA: The molecular pathogenesis of the Philadelphiapositive leukemias: Implications for diagnosis and therapy, in Freireich EJ, Kantarjian H (eds): Leukemia: Advances Research and Treatment. Deventer, The Netherlands, Kluwer Academic, 1993, p 295
7. Kurzrock R, Gutterman JU, Talpaz M: The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 319:990, 1988
8. Sawyers CL, Denny CT, Witte ON: Leukemia and the disruption of normal hematopoiesis. Cell 64:337, 1991
9. Heisterkamp N, Groffen J: Molecular insights into the Philadelphia translocation. Hematol Pathol 5:1, 1991
10. Maru Y, Witte ON: The BCR gene encodes a novel serine/ threonine kinase activity within a single exon. Cell 67:459, 1991
11. McWhirter JR, Wang JYJ: Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins. Mol Cell Biol 11:1553, 1991
12. Muller AJ, Young JC, Pendergast AM, Pondel M, Landau NR, Littman DR, Witte ON: BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol Cell Biol 11:1785, 1991
13. Eva A, Aaronson SA: Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature 316:273, 1985
14. Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA: Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature 354:311, 1991
15. rac. Nature 351:400, 1991
16. Hart MJ, Maru Y, Leonard D, Witte ON, Evans T, Cerione A: A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42. Science 258:812, 1992
17. Voncken JW, Van Schaick H, Kaartinen V, Landing B, Pattengale PK, Deemer K, Coates T, Dorseuil O, Bokoch GM, Groffen J, Heisterkamp N: Increased neutrophil respiratory burst in bcr null mutants. Cell 80:719, 1995
18. Wang JYJ: Abl tyrosine kinase in signal transduction and cell-cycle regulation. Curr Opin Gen Dev 3:35, 1993
19. Tybulewicz VLJ, Crawford CE, Jackson PK, Bronson RT, Mulligan RC: Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153, 1991
20. ml mutation show poor viability and depletion of selected B and T cell populations. Cell 65:1165, 1991
21. Daley GQ, Van Etten R, Baltimore D: Induction of chronic myelogenous leukemia in mice by the P210 BCR/ABL gene of the Philadelphia chromosome. Science 247:824, 1990
22. Elefanty AG, Hariharan IK, Cory S: BCR/ABL, the hall mark of chronic myelogenous leukemia in man, induces multiple hemopoietic neoplasms in mice. EMBO J 9:1069, 1990
23. Kelliher MA, McLaughlin J, Witte ON. Rosenberg N: Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci USA 87:6649, 1990
24. Kelliher MA, Knott A, McLaughlin J, Witte ON, Rosenberg N: Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene. Mol Cell Biol 11:4710, 1991
25. Elefanty AG, Cory S: Hematologic disease induced in BALB/ c mice by a BCR/ABL retrovirus is influenced by the infection conditions. Mol Cell Biol 12:1755, 1992
26. Kelliher MA, Weckstein DJ, Knott AG, Wortis HH, Rosenberg N: ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice. Oncogene 8:1249, 1993
27. Fialkow PJ, Jacobson RJ, Papayannopoulou T, Penfold GK, Jacobson RT, Hansen JA: Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med 63:125, 1977
28. Heisterkamp N, Jenster G, Ten Hoeve J, Zovich D, Pattengale PK, Groffen J: Acute leukaemia in bcr/abl transgenic mice. Nature 344:251, 1990
29. Voncken JW, Morris C, Pattengale P, Dennert G, Kikly C, Groffen J, Heisterkamp N: Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice. Blood 79:1029, 1992
30. Voncken JW, Griffiths S, Greaves MF, Pattengale PK, Heisterkamp N, Groffen J: Restricted oncogenicity of BCR/ABL P190 in transgenic mice. Cancer Res 52:4534, 1992
31. Heisterkamp N, Jenster G, Kioussis D, Pattengale PK, Groffen J: Human BCR/ABL gene has a lethal effect on embryogenesis. Transgenic Res 1:45, 1991
32. Stuart GW, Searle PF, Chen HY, Brinster RL, Palmiter RD: A 12 base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc Natl Acad Sci USA 81:7318, 1984
33. Pattengale PK, Stewart TA, Leder A, Sinn E, Muller W, Tepler I, Schmidt E, Leder P: Molecular analysis of transgenic mice carrying and expressing activated oncogenes. Am J Pathol 135:39, 1989
34. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
35. Kawasaki ES, Clark SS, Coyne MY, Smith SD, Champlin R, Witte ON, McCorrmick FP: Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia specific mRNA sequences amplified in vitro. Proc Natl Acad Sci USA 85:5698, 1988
36. Alonso S, Minty A, Bourlet Y, Buckingham M: Comparison of three actin-coding sequences in the mouse; evolutionary relationships between the actin genes of warm-blooded vertebrates. J Mol Evol 23:11, 1986
37. Harlow E, Lane D: Antibodies: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1988
38. 1-positive leukemia: A transgenic mouse model. Leuk Lymphoma 10:1, 1993 (suppl 2)
39. Clark SS, Chen E, Fizzotti M, Witte ON, Malkovska V: BCR/ ABL and v-abl oncogenes induce distinct patterns of thymic lymphoma involving different lymphocyte subsets. J Virol 67:6033, 1993
40. Hanecak R, Pattengale PK, Fan H: Addition or substitution of simian virus 40 enhancer sequences into the Moloney murine leukemia virus (M-MuLV) long terminal repeat yields infectuous M-MuLV with altered biological properties. J Virol 62:2427, 1988
41. Pattengale PK: Tumours of the lymphohaematopoietic system, in Turusov V, Mohr U (eds): Pathology of Tumours in Laboratory Animals. Lyon, France, International Agency for Research on Cancer (WHO), 1994, p 651
42. Daley GQ: Animal models of BCR/ABL-induced leukemias. Leuk Lymphoma 11:57, 1993
43. BCR/ABL by metallothionein promoter induced T-cell leukemia in transgenic mice. Blood 85:2853, 1995
44. Lugo TG, Pendergast A-M, Muller AJ, Witte ON: Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 247:1079, 1990
45. Mayer BJ, Ren R, Clark KL, Baltimore D: A putative modular domain present in diverse signalling proteins. Cell 73:629, 1993
46. Gishizky ML. Johnson-White J, Witte ON: Efficient transplantation of BCR/ABL-induced chronic myelogenous leukemia like syndrome in mice. Proc Natl Acad Sci USA 90:3755, 1993
47. Hariharan IK, Harris AW, Crawford M, Abud H, Webb E, Cory S, Adams JM: A bcr-v-abl oncogene induces lymphomas in transgenic mice. Mol Cell Biol 9:2798, 1989
48. Akashi K, Taniguchi S, Nagafuji K, Harada M, Shibuya T, Hayashi S, Gondo H, Niho Y: B-lymphoid/myeloid stem cell origin in Ph-positive acute leukemia with myeloid markers. Leuk Res 17:549, 1993
49. Akashi K, Mizuno S, Harada M, Kimura N, Kinjyo M, Shibuya T, Shimoda K, Takeshita M, Okamura S, Matsumoto I, Kikuchi M, Niho Y: T-lymphoid/myeloid bilineal crisis in chronic myelogenous leukemia. Exp Hematol 21:743, 1993
50. Martin M, Strasser A, Baumgarth N, Cicuttini FM, Welch K, Salvaris E, Boyd AW: A novel cellular model (SPGM 1) of switching between pre-B cell and myelomonocytic lineages. J Immunol 150:4395, 1993
51. Jacks T, Fazeli AM, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA: Effects of an Rb mutation in the mouse. Nature 359:295, 1992
52. Frith CH, Wiley LD: Classification an incidence of hyperplastic and neoplastic hematopoietic lesions in mice. J Geront 36:534, 1981
53. Berger R: Differences between blastic chronic myeloid leukemia and Ph-positive acute leukemia. Leuk Lymphoma 11:235, 1993