Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice

Nature Medicine

Volumn 1, Issue 12, 1995, Pages 1268-1273

  Bachar Lustig, Esther ^a   Rachamim, Nurit ^a   Li, Hong Wei ^a   Lan, Fenshou ^a   Reisner, Yair ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; HLA ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; FEMALE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL; HLA MATCHING; HLA MISMATCH; IMMUNE DEFICIENCY; IRRADIATION; LEUKEMIA; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; BONE MARROW TRANSPLANTATION; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HYBRID CELLS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, SCID; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; WHOLE-BODY IRRADIATION;

EID: 0028789191     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1295-1268     Document Type: Article

References (35)

1. Reisner, Y. et al. Transplantation for severe combined immunodeficiency with HLA-A, B, D, DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells. Blood 61, 341-348 (1983).
2. Gale, R. P. & Reisner, Y. Graft rejection and graft-versus-host-disease: Mirror images. Lance i, 1468-1470 (1986)
3. Gengozian, N., Carlson, D. E. & Allen, E. M. Transplantation of allogeneic and xenogeneic (rat) marrow in irradiated mice as affected by radiation exposure rates. Transplantation 7, 259-273 (1969)
4. Vriesendorp, H. M. Engraftment of hemopoietic cells, in Bone Marrow Transplantation: Biological Mechanisms and Clinical Practic (ed. Lowenberg, D. W. & van Bekkum, B. ) 73-145 (Dekker, New York, 1985).
5. Lapidot, T., Terenzi, A., Singer, T. S. & Reisner, Y. Size of bone marrow inoculum versus number of donor-type cells used for presensitization: A murine model for bone marrow allograft rejection in leukemia patients. Blood 70, 309a (1987)
6. Lapidot, T., Terenzi, A., Singer, T. S., Salomon, O. & Reisner, Y. Enhancement by dimethyl myleran of donor type chimerism in murine recipients of bone marrow allografts. Bloo 73, 2025-2032 (1989).
7. Soderling, C. C., Song, C. W., Blazer, B. R. & Vallera, D. A. A correlation between conditioning and engraftment in recipients of MHC mismatched T cell-depleted murine bone marrow transplants. Immunolog 135, 941-946 (1985).
8. Ferrara, J., Lipton, J., Heilman, S., Burakoff, S. & Mauch P. Engraftment following T cell-depleted maπow transplantation. I. The role of major and minor histocompatibility barriers. Transplantatio 43, 461-467 (1987).
9. Uharek, L. et al. Influence of cell dose and graft-versus-host reactivity on rejection rates after allogeneic bone marrow transplantation. Bloo 79, 1612-1621 (1992).
10. Gianni, A. M. et al. Granulocyte-macrophage colony stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation. Lance ii, 580-585 (1989)
11. Aversa, F. et al. Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Bloo 84, 3948-3955 (1994).
12. Lapidot, T., Lubin, I., Faktorowich, Y., Erlich, P. & Reisner, Y. Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host activity. Proc. natn. Acad. Sci. U. S. A 87, 4595-4599 (1990).
13. Martin, P. J. Donor CD8 cells prevent allogeneic marrow graft rejection in mice: Potential implications for marrow transplantation in humans. J. exp. Med 178, 703-712 (1993).
14. Sykes, M., Sheard, M. & Sachs, D. H. Effects of T cell depletion in radiation bone marrow chimers. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD. J. Immun 141, 2282-2288 (1988).
15. Navarro, J. St Touraine, J.-L. Promotion of fetal liver engraftment by T-cells in a murine semiallogeneic model without graft-versus-host reaction. Transplantatio 47, 871-876 (1989).
16. Faktorowich, Y., Lapidot, T., Lubin, I. & Reisner, Y. Enhancement of BM allografting from C57BL/6 'nude' mice into C3H/HeJ recipients by tolerized T cells from (C57BL/6->C3H/HeJ) and (C3H/HeJ→C57BL/6) chimeras. Bone Maπow Transplant 12, 15-20 (1993).
17. Slavin, S., Strober, S., Fuks, Z. & Kaplan, H. S. Induction of specific tissue transplantation tolerance using fractionated total lymphoid iradiation in adult mice: Long-term survival of allogeneic bone marrow and skin grafts. J. exp. Med 146, 34-48 (1977).
18. Pierce, G. & Watts L. The role of donor lymphoid cells in the transfer of allograft tolerance. Transplantatio 40, 702-707 (1985).
19. Cobbold, S., Martin, G. & Qin, S. & Waldmann H. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Natur 323, 164-166 (1986).
20. Sharabi, Y. & Sachs, D. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J. exp. Med. 169, 493-502 (1989).
21. Mayumi, H. & Good, R. Long-lasting skin allograft tolerance in adult mice induced across fully allogeneic (multimajor H-2 plus multiminor histocompatibility) antigen barriers by a tolerance — inducing method using cyclophosphamide. J. exp. Med 169, 213-238 (1989).
22. Qin, S., Cobbold, S., Benjamin, R. & Waldmann H. Induction of classical transplantation tolerance in the adult. /. exp. Med 169, 779-794 (1989).
23. Leong, L., Qin, S., Cobbold, S. & Waldmann, H. Classical transplantation tolerance in the adult: The interaction between myeloablation and immunosuppre-tion. Eur. J. Immun 22, 2825-2830 (1992).
24. Pierce, G. E. & Watts, L. M. Do donor cells function as veto cells in the induction and maintenance of tolerance across an MHC disparity in mixed lymphoid radiation chimeras? Transplantatio 55, 882-887 (1993).
25. Pierce, G. E. & Watts, L. M. Thy 1+ donor cells function as veto cells in the maintenance of tolerance across a major histocompatibility complex disparity in mixed-lymphoid radiation chimeras. Transplantn Proc 25, 331-333 (1993).
26. Kiyoshi, H., Nakamura, H., Henkart, P. & Gress R. Clonal deletion of post-thymic T cells: Veto cells kill precursor cytotoxic T lymphocytes. J. exp. Med 175, 863-868 (1992).
27. Tscheming, T. & Claesson, M. Veto-like down regulation of T helper cell reactivity in vivo by injection of semi-allogeneic spleen cells. Immunology Lett 29, 223-228 (1991).
28. Kikuya, S., Inaba, M., Ogata, H., Yasumizu, R. & Inaba, K. Wheat germ agglutinin-positive cells in a stem cell-enriched fraction of mouse bone marrow have potent natural suppressor activity. Proc. natn. Acad. Sci. U. S. A 85, 4824-4826 (1988).
29. Strober, S., Palathumpat, V., Schwadron, R. & Hertel-Wulff, B. Cloned natural suppressor cells prevent lethal graft-vs-host disease. J. Immun 138, 699-703 (1987).
30. Kaufman, C. L. et al. Phenotypic characterization of a novel bone marrow derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Bloo 84, 2436-2446 (1994).
31. Ramsdell, F. & Fowlkes, B. Maintenance of in vivo tolerance by persistence of antigen. Scienc 257, 1130-1134 (1992).
32. Rocha, B., Tanchot, C. & Von Boehmer, H. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. exp. Med 177, 1517-1521 (1993).
33. Reisner, Y., Itzicovitch, L., Meshorer, A. & Sharon, N. Hematopoietic stem cell transplantation using mouse bone marrow and spleen cells fractionated by lectins. Proc. natn. Acad. Sci. U. S. A 75, 2933-2936 (1978).
34. Schwartz, E., Lapidot, T., Gozes, D., Singer, T. S. & Reisner, Y. Abrogation of bone marrow allograft resistance in mice by increased total body irradiation correlates with eradication of host clonable T-cells and alloreactive cytotoxic precursors. J. Immun 138, 460-465 (1987)
35. Ryser, J. E. & MacDonald, H. R. Limiting dilution analysis of alloantigen-reactive T lymphocytes. I. Comparison of precursor frequencies for proliferative and cytolytic responses. J. Immun 122, 1691-1696 (1979).