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0021369651
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Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces
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Kilmartin1
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3
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0021355377
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Relationship of actin and tubulin distribution to bud growth in wild-type and morphogenetic mutant Saccharomyces cerevisiae
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(1984)
J Cell Biol
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Adams1
Pringle2
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5
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0028204439
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Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane
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of special interest, Ultrastructural analyses of membrane-associated actin filaments suggest that filaments are intimately associated with sites of plasma membrane fusion with transport vesicles.
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(1994)
J Cell Biol
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, pp. 381-391
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Mulholland1
Preuss2
Moon3
Wong4
Drubin5
Botstein6
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6
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-
0028871169
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Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast
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of special interest, Describes initial attempts to reconstitute assembly of the actin cytoskeleton in a lysed cell model. The authors find that Cdc42 and actin-binding protein mutants are unable to correctly assemble actin filaments at the bud site in vitro.
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(1995)
J Cell Biol
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Li1
Zheng2
Drubin3
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8
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-
0028352176
-
Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae
-
of special interest, With [9], this paper establishes the long suspected role of actin filaments and a myosin homolog, Myo2, in polarized secretion during budding. The authors also discuss Smy1, a kinesin homolog that probably promotes transport along cytoplasmic microtubules but, unpredictably, may turn out to be an actin-based motor.
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(1994)
J Cell Biol
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, pp. 825-842
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Lillie1
Brown2
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9
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-
0028902506
-
The role of Myo2, a yeast class V myosin, in vesicular transport
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of special interest, With [8], this paper establishes the role of actin filaments and Myo2 in polarized secretion during budding.
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(1995)
J Cell Biol
, vol.128
, pp. 1055-1068
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-
Govindan1
Bowser2
Novick3
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10
-
-
0029045404
-
Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae
-
of special interest, Secretion of new cell walls can occur at a prodigious rate. The bud site assembles as a specialized secretory organelle in which components of the secretory apparatus accumulate to form an active complex.
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(1995)
J Cell Biol
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, pp. 299-312
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TerBush1
Novick2
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11
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0028931727
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Patterns of bud-site selection in the yeast Saccharomyces cerevisiae
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(1995)
J Cell Biol
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Chant1
Pringle2
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12
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-
0028944608
-
Role of Bud3p in producing the axial budding pattern of yeast
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of special interest, Bud3 may be the unstable protein which marks the previous bud site, acting as a focal point for assembly of neck filaments and/or actin in preparation for axial budding in the next cell cycle in haploid cells.
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(1995)
J Cell Biol
, vol.129
, pp. 767-778
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Chant1
Mischke2
Mitchell3
Herskowitz4
Pringle5
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13
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0027264558
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BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast
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(1993)
Nature
, vol.365
, pp. 269-274
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Park1
Chant2
Herskowitz3
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14
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-
0027490707
-
Genetic evidence for the roles of the bud-site-selection genes BUD5 and BUD2 in control of the Rsr1p (Bud1p) GTPase in yeast
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(1993)
Proc Natl Acad Sci USA
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, pp. 9926-9929
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Bender1
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17
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0028073155
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Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation
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1 cyclin activity. Is there a possible connection to the budding checkpoint described in [32]?
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(1994)
J Cell Biol
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, pp. 1381-1394
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Kim1
Francisco2
Chen3
Marcotte4
Chan5
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18
-
-
0028023358
-
Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3
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of special interest, Describes the identification of morphogenesis proteins as regulators of Cdc42 activity.
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(1994)
J Biol Chem
, vol.269
, pp. 2369-2372
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-
Zheng1
Cerione2
Bender3
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20
-
-
0028955710
-
Interactions among proteins involved in bud-site selection and bud-site assembly in Saccharomyces cerevisiae
-
of special interest, Describes the integration of several components (including Bem1, Cdc24, Cdc42 and Bud1) of the bud emergence pathway into a single complex with multiple functions. Suggests how the bud site localization pathway controls bud emergence.
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(1995)
J Biol Chem
, vol.270
, pp. 626-630
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Zheng1
Bender2
Cerione3
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25
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-
0028589197
-
The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast
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1→S transition. Pcl2 expression is stimulated by mating pheromone. Is it involved in return to growth after cell cycle arrest?
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(1994)
Science
, vol.266
, pp. 1391-1395
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Measday1
Moore2
Ogas3
Tyers4
Andrews5
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26
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0027414941
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Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins
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(1993)
J Cell Biol
, vol.120
, pp. 1305-1320
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Lew1
Reed2
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27
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0027330925
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Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation
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(1993)
EMBO J
, vol.12
, pp. 5277-5286
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Cvrčková1
Nasmyth2
-
29
-
-
0029091498
-
Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.
-
of special interest, of outstanding interest, The Cla4 protein is a novel p21 (Cdc42/Rac)-activated kinase (PAK) homolog involved in bud emergence (see also annotation [30]). It may integrate actin localization at the bud site with positioning of the septins at the bud neck. Double mutants lacking Cla4 and Ste20 are unable to complete budding as they fail to form a bud neck. Which, if any, known mitogen-activated protein kinase pathways depend upon Cla4 function for activation remains somewhat unclear. The Hog1 osmotic-response pathway is a candidate.
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(1995)
Genes & Development
, vol.9
, pp. 1817-1830
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-
Cvrčková1
De Virgilio2
Manser3
Pringle4
Nasmyth5
-
30
-
-
0028078824
-
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
-
of special interest, Establishes the paradigm for signalling kinases whose activity is regulated by the activated form of the small GTPase Cdc42. PAK is a homolog of Ste20. Both kinases bind Cdc42. This paper suggests that Cdc24 and Cdc42 may be upstream elements of the pheromone responsive MAPK pathway.
-
(1994)
Nature
, vol.367
, pp. 40-46
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-
Manser1
Leung2
Salihuddin3
Zhao4
Lim5
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31
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-
0029056399
-
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
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(1995)
EMBO J
, vol.14
, pp. 1970-1978
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-
Martin1
Bollag2
McCormick3
Abo4
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32
-
-
0028915943
-
A cell cycle checkpoint monitors cell morphogenesis in budding yeast
-
of outstanding interest, The authors demonstrate that even in yeast-form growth, bud size is monitored, feeding back to control mitotic progression. Cdc24 mutants, which fail to bud [23], have a long delay before mitosis. Control in these mutants is both via Swe1-dependent phosphorylation of the conserved tyrosine of Cdc28, which inhibits Clb-dependent kinase activity, and via inhibitory regulation in Clb expression.
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(1995)
J Cell Biol
, vol.129
, pp. 739-749
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Lew1
Reed2
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33
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0027326257
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Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins
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(1993)
EMBO J
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, pp. 417-3426
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Booher1
Deshaies2
Kirschner3
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36
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0027984898
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Repression of growth-regulated G1 cyclin expression by cyclic AMP in budding yeast
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(1994)
Nature
, vol.371
, pp. 339-342
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Baroni1
Monti2
Alberghina3
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41
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-
0028194848
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Control of meiotic gene expression in Saccharomyces cerevisiae
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(1994)
Microbiol Rev
, vol.58
, pp. 56-70
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-
Mitchell1
-
42
-
-
0028121981
-
SPO13 negatively regulates the progression of mitotic and meiotic nuclear division in Saccharomyces cerevisiae
-
of special interest, Is the CDK inhibitor Spo13 specific for meiosis I? When ectopically expressed, it inhibits mitosis.
-
(1994)
Genetics
, vol.138
, pp. 47-60
-
-
McCarroll1
Esposito2
-
43
-
-
0027967087
-
SMK1, a developmentally regulated MAP kinase, is required for spore wall assembly in Saccharomyces cerevisiae
-
of special interest, With [44], this paper establishes a new MAPK pathway that promotes differentiation in spore formation.
-
(1994)
Genes Dev
, vol.8
, pp. 2151-2161
-
-
Krisak1
Strich2
Winters3
Hall4
Mallory5
Kreitzer6
Tuan7
Winter8
-
44
-
-
0028071624
-
Mutation of the SPS1-encoded protein kinase of Saccharomyces cerevisiae leads to defects in transcription and morphology during spore formation
-
of special interest, See annotation [43].
-
(1994)
Genes Dev
, vol.8
, pp. 2162-2175
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-
Friesen1
Lunz2
Doyle3
Segall4
-
45
-
-
11944273348
-
The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response
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2+ leaking through previously described mechanosensitive channels that detect excessive plasma membrane stress. Pkc1 stimulation may slow down secretion at several levels, perhaps to allow polymerization of components in the cell wall covering the bud site.
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(1995)
Genes Dev
, vol.9
, pp. 1559-1571
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-
Kamada1
Jung2
Piotrowski3
Levin4
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46
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-
0027218647
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Polarization of yeast cells in spatial gradients of alpha mating factor
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(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8332-8336
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Segall1
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47
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0027090325
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Actin- and tubulin-dependent functions during Saccharomyces cerevisiae mating projection formation
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(1992)
Mol Biol Cell
, vol.3
, pp. 429-444
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-
Read1
Okamura2
Drubin3
-
48
-
-
0028179954
-
Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae
-
of special interest, Special mutants of Bem1 and Cdc24, proteins identified previously as required for bud emergence, specifically prevent projection formation. This suggests that pheromone sensing recruits these proteins to the site of highest receptor occupancy.
-
(1994)
Genetics
, vol.136
, pp. 1287-1296
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-
Chenevert1
Valtz2
Herskowitz3
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49
-
-
0027530380
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A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae
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(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 452-456
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-
Ramer1
Davis2
-
50
-
-
0029157469
-
Role for the rho-family GTPase Cdc42 in yeast mating phermone signal pathway
-
of outstanding interest, With [51], this paper demonstrates that Cdc42 and its guanine nucleotide exchange factor Cdc24 function in the mating pathway. The authors show that Ste20 function is directly activated by Cdc42. The genetic inference is that pheromone sensing promotes Cdc24 activity. The conclusion is that such activation is a necessary step in mating pheromone signal transduction.
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(1995)
Nature
, vol.376
, pp. 702-705
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-
Simon1
De Vergilio2
Souza3
Pringle4
Abo5
Reed6
-
51
-
-
0029118202
-
Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24
-
With [50], this paper demonstrates that Cdc42 and its GEF Cdc24 are in the mating pathway. The data suggest that Ste20 function is activated by Cdc42 and that this activation is part of the mating signal transduction pathway. Importantly, this study shows that the Ste4 β subunit binds to Cdc24, perhaps to activate exchange of guanine nucleotides on Cdc42.
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(1995)
Mol Cell Biol
, vol.15
, pp. 5246-5257
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-
Zhao1
Leung2
Manser3
Lim4
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52
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-
0029066439
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Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae
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(1995)
J Biol Chem
, vol.270
, pp. 15984-15992
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Wu1
Whiteway2
Thomas3
Leberer4
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55
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-
0027983908
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Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
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(1994)
Cell
, vol.78
, pp. 499-512
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-
Choi1
Satterberg2
Lyons3
Elion4
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57
-
-
0028046412
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Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.
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(1994)
Genetics
, vol.138
, pp. 609-619
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-
Printen1
Sprague2
-
58
-
-
0029146796
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Association of the yeast pheromone response G protein βγ subunits with the MAP kinase scaffold Ste5
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of special interest, The data suggest direct association of the Ste4 β subunit with the Ste5 scaffold and the rest of the signalling pathway.
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(1995)
Science
, vol.269
, pp. 1572-1575
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Whiteway1
Wu2
Leeuw3
Clark4
Fourest-Lieuvin5
Thomas6
Leberer7
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59
-
-
0027253814
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FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1
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(1993)
Mol Biol Cell
, vol.4
, pp. 495-510
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-
Elion1
Satterberg2
Kranz3
-
61
-
-
0027261380
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Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes
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(1993)
Mol Cell Biol
, vol.13
, pp. 5659-5669
-
-
Tyers1
Futcher2
-
62
-
-
0028085427
-
Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1
-
of special interest, This paper shows that Far1 is a CDK inhibitor in vitro.
-
(1994)
Science
, vol.265
, pp. 1228-1231
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-
Peter1
Herskowitz2
-
63
-
-
0028884447
-
Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin
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of outstanding interest, This paper proposes a signalling complex that is significantly larger than previously considered. The data establish a link between the Ste5 scaffold and associated kinases, and the actin cytoskeleton, via the SH3 protein Bem1. This suggests that the signalling pathway is as much a pathway for achieving assembly as a phosphorylation cascade.
-
(1995)
Science
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Leeuw1
Fourest-Lieuvin2
Wu3
Chenevert4
Clark5
Whiteway6
Thomas7
Leberer8
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64
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0029012079
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Ste5: a meeting place for MAP kinases and their associates
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(1995)
Trends Biochem Sci
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Elion1
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66
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0028057744
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The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5
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(1994)
Genes Dev
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, pp. 313-327
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Kranz1
Satterberg2
Elion3
-
67
-
-
0028889717
-
FAR1 is required for oriented polarization of yeast cells in response to mating pheromones.
-
of special interest, This interesting study shows that the CKI Far1 has separable functions in cell cycle arrest and projection formation.
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(1995)
J Cell Biol
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Valtz1
Peter2
Herskowitz3
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69
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0026588787
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Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS
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(1992)
Cell
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, pp. 1077-1090
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Gimeno1
Ljungdahl2
Styles3
Fink4
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71
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0028265881
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Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development
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(1994)
Mol Cell Biol
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, pp. 2100-2112
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Gimeno1
Fink2
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72
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0029047498
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Mutational analysis of morphologic differentiation in Saccharomyces cerevisiae
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of special interest, Reviews prior genetic studies of dimorphism in S. cerevisiae. Presents evidence that a wide range of gene products affect cell shape and/or nutritional signalling.
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(1995)
Genetics
, vol.140
, pp. 1259-1275
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Blacketer1
Madaule2
Myers3
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73
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0028147205
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Symmetric cell division in pseudohyphae of the yeast Saccharomyces cerevisiae
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2→M.
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(1994)
Mol Biol Cell
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, pp. 1003-1022
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Kron1
Styles2
Fink3
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74
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-
0028175198
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G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Start in the yeast cell cycle
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(1994)
Genes Dev
, vol.8
, pp. 1058-1070
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Oehlen1
Cross2
-
75
-
-
0028986667
-
G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast
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1 cyclin instability requires the Grr1 protein. Cells lacking Grr1 are constitutively pseudohyphal. Is stabilization of cyclins an essential outcome of the pathway controlling dimorphism?
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(1995)
Genes Dev
, vol.9
, pp. 399-409
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Barral1
Jentsch2
Mann3
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76
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-
0028670651
-
Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth
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of special interest, This paper explores filamentous growth in haploid cells. Extending the results of [77], this paper shows that the mating pheromone MAPK pathway can serve two functions in the same cell, alternately controlling pheromone sensitivity and agar invasion.
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(1994)
Genes Dev
, vol.8
, pp. 2974-2985
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Roberts1
Fink2
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77
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0027759277
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Elements of the yeast pheromone response pathway required for filamentous growth of diploids
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(1993)
Science
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, pp. 1741-1744
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Liu1
Styles2
Fink3
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78
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0028604332
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Growth and guidance of the fungal hypha
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(1994)
Microbiology
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Gow1
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79
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0021837098
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Temporal and spatial differences in cell wall expansion during bud and mycelium formation in Candida albicans
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(1985)
J Gen Microbiol
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Staebell1
Soll2
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80
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0022456151
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Differences in actin localization during bud and hypha formation in the yeast Candida albicans
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(1986)
J Gen Microbiol
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Anderson1
Soll2
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81
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0028068652
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Identification of a putative transcription factor in Candida albicans that can complement the mating defect of Saccharomyces cerevisiae ste12 mutants
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(1994)
J Biol Chem
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, pp. 22945-22951
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Malathi1
Ganesan2
Datta3
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82
-
-
0028569082
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Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog
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of special interest, This paper suggests that a MAP kinase pathway analogous to the pheromone-response pathway of S. cerevisiae functions to signal dimorphic development in C. albicans. Is this a general feature of dimorphic yeasts?
-
(1994)
Science
, vol.266
, pp. 1723-1726
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-
Liu1
Kohler2
Fink3
-
84
-
-
0028173675
-
identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle
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of special interest, In Ustilago, conjugation to form a dikaryon potentiates filamentous growth. Here a MAPKK, fuz7, is described that may integrate pheromone signalling and nutritional signals in maintaining filamentous growth.
-
(1994)
Genes Dev
, vol.8
, pp. 1367-1378
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-
Banuett1
Herskowitz2
|