The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells

EMBO Journal

Volumn 14, Issue 20, 1995, Pages 5048-5059

  Okazaki, Kenji ^a   Sagata, Noriyuki ^a,b  

^a KURUME UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Fos; MAP kinase; Mos; Phosphorylation; Protein degradation

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; PROTEIN SERINE THREONINE KINASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; MOUSE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0028787249     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1995.tb00187.x     Document Type: Article

References (16)

1. cdc2, cAMP-dependent protein kinase and protein kinase C at multiple sites clustered within regulatory regions. Oncogene, 6, 2179-2185.
2. Ahn,N.G., Weiel,J.E., Chan,C.P. and Krebs,E.G. (1990) Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinase from Swiss 3T3 cells. J. Biol. Chem., 265, 11487-11494.
3. Alessi,D.R., Smythe,C. and Keyse,S.M. (1993) The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogene ras in Xenopus oocyte extracts. Oncogene, 8, 2015-2020.
4. raf-1. EMBO J., 13, 1610-1619.
5. Alyarez,E., Northwood,I.C., Gonzalez,F.A., Latour,D.A., Seth,A., Abate,C., Curran,T. and Davis,R.J. (1991) Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation: characterization of the phosphorylation of c-Myc and c-Jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J. Biol. Chem., 266, 15277-15285.
6. Anderson,N.G., Maller,J.L., Tonks,N. and Sturgill,T.W. (1990) Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature, 343, 651-653.
7. Angel,P., Imagawa,M., Chiu,R., Stein,B., Imbra,R.J., Rahmsdorf,H.J., Jonat,C., Herrlich,P. and Karin,M. (1987) Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell, 49, 729-739.
8. Barber,J.R. and Verma,J.M. (1987) Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12. tetradecanoyl-phorbol-13-acetate and serum. Mol. Cell. Biol., 7, 2201-2211.
9. Binétruy,B., Smeal,T. and Karin,M. (1991) Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature, 351, 122-127.
10. Blenis,J. (1993) Signal transduction via the MAP kinases. Proc. Natl Acad. Sci. USA. 90, 5889-5892
11. Bravo,R., Burckhardt,J., Curran,T. and Müller,R. (1986) Expression of c-fos in NIH 3T3 cells is very low but inducible throughout the cell cycle. EMBO J., 5, 695-700.
12. Brusselbach,S., Möhle-Steinlein,U., Wang,Z., Schreiber,M., Lucibello,F.C., Müller,R. and Wagner,E.F. (1995) Cell proliferation and cell cycle I progression are not impaired in fibroblasts and ES cells lacking c-Fos. Oncogene, 10, 79-86.
13. Cano,E. and Mahadevan,L.C. (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci., 20, 117-122.
14. Casanova,J.E., Breitfeld,P.P., Ross,S.A. and Mostov,K.E. (1990) Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis. Scienee, 248, 742-745.
15. Chen,R.-H., Abate,C. and Blenis,J. (1993) Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proc. Natl Acad. Sci. USA. 90, 10952-10956.
16. Chiu,R., Boyle,W.J., Meek,J., Smeal,T., Hunter,T. and Karin,M. (1988) The c-fos protein interacts with c-jun/AP-1 to stimulate transcription of AP-1-responsive genes. Cell, 54, 541-552.