Inhibition of all-trans-retinoic acid metabolism by fluconazole in vitro and in patients with acute promyelocytic leukemia

Biochemical Pharmacology

Volumn 50, Issue 7, 1995, Pages 923-928

  Schwartz, Edward L ^a   Hallam, Steven ^a   Gallagher, Robert E ^a   Wiernik, Peter H ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

acute promyelocytic leukemia; all trans retinoic acid; fluconazole; human hepatic microsomes; retinoic acid metabolism; retinoic acid pharmacokinetics

Indexed keywords

ANTIFUNGAL AGENT; CYTOCHROME P450; FLUCONAZOLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RETINOIC ACID; TRIAZOLE DERIVATIVE;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; AREA UNDER THE CURVE; ARTICLE; CASE REPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER MICROSOME METABOLISM; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; VAGINA CANDIDIASIS; VITAMIN METABOLISM;

ADULT; ANTIFUNGAL AGENTS; CASE REPORT; DRUG INTERACTIONS; FEMALE; FLUCONAZOLE; HUMAN; IN VITRO; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICROSOMES, LIVER; MIDDLE AGE; SUPPORT, U.S. GOV'T, P.H.S.; TRETINOIN;

EID: 0028786006     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)00213-J     Document Type: Article

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