Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

Cell

Volumn 83, Issue 2, 1995, Pages 301-311

  Hibbs, Margaret L ^a   Tarlinton, David M ^b   Armes, Jane ^c   Grail, Dianne ^a   Hodgson, George ^a   Maglitto, Rosemarie ^a   Stacker, Steven A ^a   Dunn, Ashley R ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c AUSTIN HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RNA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CONTROLLED STUDY; CROSS LINKING; DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GLOMERULONEPHRITIS; HYPERIMMUNOGLOBULINEMIA; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA;

EID: 0028784215     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90171-X     Document Type: Article

References (47)

1. Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development
2. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
3. The CD40 antigen and its ligand
4. Insights into lymphocyte development from X-linked immune deficiencies
5. Complete structure and expression in transfected cells of high affinity IgE receptor
6. The src family of tyrosine protein kinases in hemopoietic signal transduction
7. Anti-immunoglobulin stimulation of B lymphocytes activates srcrelated protein-tyrosine kinases
8. Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin
9. Association between B-lymphocyte membrane immunoglobulin and multiple members of the src family of protein tyrosine kinases
10. The B cell antigen receptor complex: association of Ig-α and Ig-β with distinct cytoplasmic effectors
11. Mechanism and regulation of immunoglobulin isotype switching
12. Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation
13. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival
14. Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases
15. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene
16. Genetic and immunological mechanisms in the pathogenesis of SLE
17. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases
18. +thymocytes
19. Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor
20. Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking
21. Use of BRL-conditioned media in combination with feeder layers to isolate a diploid embryonal stem cell line
22. The “Ly-1 B” cell subpopulation in normal, immunodefective, and autoimmune mice
23. Identification of a duplication of the mouse Lyn gene
24. Normal B lymphocyte development but impaired T cell maturation in CD45-exon 6 protein tyrosine phosphatase-deficient mice
25. + B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP
26. Germinal centers
27. Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation
28. Murine models for systemic lupus erythematosus and Sjogren's syndrome
29. fyn8 domains associate with nonphosphorylated and phosphorylated Ig-α
30. The B-cell antigen receptor complex: structure and signal transduction
31. Fc receptors: rubor redux
32. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
33. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2
34. Antigen receptors on B lymphocytes
35. + B cells in viable motheaten and normal mice
36. Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers
37. Alternatively spliced murine lyn mRNAs encode distinct proteins
38. lyn
39. FcR γ chain deletion results in pleiotrophic effector cell defects
40. Defective antigen receptor-mediated proliferation of B and T cells in the absence of vav
41. Colocalization of X-linked agammaglobulinemia and X-linked immunodefiency genes
42. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
43. Cancer genes and hematopoiesis
44. fgr is expressed in murine splenic B cells and is activated in responsetoantigen receptor cross-linking
45. 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin: demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells
46. Association of B cell antigen receptor with protein tyrosine kinase lyn
47. Defective signalling through the T- and B-cell antigen receptors in lymphoid cell lacking the vav proto-oncogene