Acute pancreatitis

New England Journal of Medicine

Volumn 330, Issue 17, 1994, Pages 1198-1210

  Steinberg, William ^a   Tenner, Scott ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE DISEASE; HUMAN; PANCREATITIS; PATHOPHYSIOLOGY; PROGNOSIS; REVIEW; ACUTE PANCREATITIS; COMMON BILE DUCT CYST; CROHN DISEASE; GALLSTONE; HYPERPARATHYROIDISM; HYPERTRIGLYCERIDEMIA; PANCREAS CANCER; PANCREAS DUCT STENOSIS; PANCREAS INJURY; PANCREAS SURGERY; PEPTIC ULCER; PRIORITY JOURNAL; TREATMENT PLANNING; VATER PAPILLA STENOSIS;

ACUTE DISEASE; HUMAN; PANCREATITIS; PROGNOSIS;

ALCOHOL; AMINOSALICYLIC ACID; AMPICILLIN; APROTININ; ATROPINE; AZATHIOPRINE; CALCITONIN; CIMETIDINE; DIDANOSINE; FLUOROURACIL; GABEXATE; GLUCAGON; MERCAPTOPURINE; METHANOL; METRONIDAZOLE; ORGANOPHOSPHATE INSECTICIDE; PARACETAMOL; PENTAMIDINE; SCORPION VENOM; SOMATOSTATIN; SULFONAMIDE; VALPROIC ACID;

EID: 0028781626     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199404283301706     Document Type: Review

References (184)

1. Moynihan B Acute pancreatitis. Ann Surg 1925; 81: 132-142
2. Fitz RH Acute pancreatitis: a consideration of pancreatic hemorrhage, hemorrhagic, suppurative, and gangrenous pancreatitis, and of disseminated fat-necrosis. Boston Med Surg J 1889; 120: 181-7, 205
3. Leach SD, Gorelick FS, Modlin IM Acute pancreatitis at its centenary: the contribution of Reginald Fitz. Ann Surg 1990; 212: 109-113
4. Opie EL The relation of cholelithiasis to disease of the pancreas and to fat necrosis. Am J Med Sci 1901; 121: 27-43
5. Symmers WSC Acute alcoholic pancreatitis. Dublin J Med Sci 1917; 143: 244-247
6. Detailed diagnoses and procedures, National Hospital Discharge Survey, 1987. Vital Health Stat [13] 1989; 100: 1-304
7. National Center for Health Statistics. Vital statistics of the United States, 1987. Vol. II. Part A. Mortality. Washington, D.C.: Government Printing Office, 1987. (DHHS publication no. PHS 87-1101).
8. Cavallini G, Riela A, Brocco G, et al. Epidemiology of acute pancreatitis. In: Beger HG, Buchler M, eds. Acute pancreatitis: research and clinical management. Berlin, Germany: Springer-Verlag, 1987:25-31.
9. Thomson SR, Hendry WS, McFarlane GA, Davidson AI Epidemiology and outcome of acute pancreatitis. Br J Surg 1987; 74: 398-401
10. Variation in annual incidence of primary acute pancreatitis in Nottingham, 1969-74, J.B., Bourke, Lancet, (1975), 2, 967-969
11. Wilson C, Imrie CW Changing patterns of incidence and mortality from acute pancreatitis in Scotland, 1961-1985. Br J Surg 1980; 77: 731-734
12. Maxson CJ, Greenfield SM, Turner JL Acute pancreatitis as a common complication of 2',3'-dideoxyinosine therapy in the acquired immunodeficiency syndrome. Am J Gastroenterol 1992; 87: 708-713
13. Imrie CW, Whyte AS A prospective study of acute pancreatitis. Br J Surg 1975; 62: 490-494
14. Ranson JHC, Rifkind KM, Turner JW Prognostic signs and nonoperative peritoneal lavage in acute pancreatitis. Surg Gynecol Obstet 1976; 143: 209-219
15. Blamey SL, Imrie CW, O'Neill J, Gilmour WH, Carter DC Prognostic factors in acute pancreatitis. Gut 1984; 25: 1340-1346
16. Bird NC, Goodman AJ, Johnson AG Serum phospholipase A2 activity in acute pancreatitis: an early guide to severity. Br J Surg 1989; 76: 731-732
17. London NJM, Neoptolemos JP, Lavelle J, Bailey I, James D Contrast-enhanced abdominal computed tomography scanning and prediction of severity of acute pancreatitis: a prospective study. Br J Surg 1989; 76: 268-272
18. Leese T, Shaw D, Holliday M Prognostic markers in acute pancreatitis: can pancreatic necrosis be predicted? Ann R Coll Surg Engl 1988; 70: 227-232
19. Fan S-T, Lai ECS, Mok FPT, Lo C-M, Zheng S-S, Wong J Early treatment of acute biliary pancreatitis by endoscopic papillotomy. N Engl J Med 1993; 328: 228-232
20. Corfield AP, Cooper MJ, Williamson RCN, Prediction of severity in acute pancreatitis: prospective comparison of three prognostic indices. Lancet 1985; 2: 403-407
21. Gross V, Scholmerich J, Leser H-G, Granulocyte elastase in assessment of severity of acute pancreatitis: comparison with acute-phase proteins C-reactive protein, α1-antitrypsin, and protease inhibitor alpha2-macroglobulin. Dig Dis Sci 1990; 35: 97-105
22. Clavien P-A, Robert J, Meyer P, Acute pancreatitis and normoamylasemia: not an uncommon combination. Ann Surg 1989; 210: 614-620
23. Agarwal N, Pitchumoni CS Simplified prognostic criteria in acute pancreatitis. Pancreas 1986; 1: 69-73
24. Bank S, Wise L, Gersten M Risk factors in acute pancreatitis. Am J Gastroenterol 1983; 78: 637-640
25. Demmy TL, Burch JM, Feliciano DV, Mattox KL, Jordan GL Jr Comparison of multiple-parameter prognostic systems in acute pancreatitis. Am J Surg 1988; 156: 492-496
26. Lankisch PG, Schirren CA, Otto J Methemalbumin in acute pancreatitis: an evaluation of its prognostic value and comparison with multiple prognostic parameters. Am J Gastroenterol 1989; 84: 1391-1395
27. Cuschieri A, Wood RAB, Cumming JRG, Meehan SE, Mackie CR Treatment of acute pancreatitis with fresh frozen plasma. Br J Surg 1983; 70: 710-712
28. Tran DD, Cuesta MA Evaluation of severity in patients with acute pancreatitis. Am J Gastroenterol 1992; 87: 604-608
29. Khuroo MS, Zargar SA, Yattoo GN, Ascaris-induced acute pancreatitis. Br J Surg 1992; 79: 1335-1338
30. Goldberg PB, Long WB, Oleaga JA, Mackie JA Choledochocele as a cause of recurrent pancreatitis. Gastroenterology 1980; 78: 1041-1045
31. Griffin M, Carey WD, Hermann R, Buonocore E Recurrent acute pancreatitis and intussusception complicating an intraluminal duodenal diverticulum. Gastroenterology 1981; 81: 345-348
32. Lans JI, Geenen JE, Johanson JF, Hogan WJ Endoscopic therapy in patients with pancreas divisum and acute pancreatitis: a prospective, randomized, controlled clinical trial. Gastrointest Endosc 1992; 38: 430-434
33. Lin A, Feller ER Pancreatic carcinoma as a cause of unexplained pancreatitis: report of ten cases. Ann Intern Med 1990; 113: 166-167
34. Venu RP, Geenen JE, Hogan W, Stone J, Johnson GK, Soergel K Idiopathic recurrent pancreatitis: an approach to diagnosis and treatment. Dig Dis Sci 1989; 34: 56-60
35. Patti MG, Pellegrini CA Gallstone pancreatitis. Surg Clin North Am 1990; 70: 1277-1295
36. Bartholomew C Acute scorpion pancreatitis in Trinidad. BMJ 1970; 1: 666-668
37. Bennett IL Jr, Cary FH, Mitchell GL, Cooper MN Acute methyl alcohol poisoning: a review based on experiences in an outbreak of 323 cases. Medicine (Baltimore) 1953; 32: 431-463
38. Lee HS Acute pancreatitis and organophosphate poisoning — a case report and review. Singapore Med J 1989; 30: 599-601
39. Singh M, Simsek H Ethanol and the pancreas: current status. Gastroenterology 1990; 98: 1051-1062
40. Banerjee AK, Patel KJ, Grainger SL Drug-induced acute pancreatitis: a critical review. Med Toxicol Adverse Drug Exp 1989; 4: 186-198
41. Steinberg WM Acute drug and toxin induced pancreatitis. Hosp Practice (Off Ed) 1985; 20: 95-102
42. Mallory A, Kern F Jr Drug-induced pancreatitis: a critical review. Gastroenterology 1980; 78: 813-820
43. Wilson RH, Moorhead RJ Current management of trauma to the pancreas. Br J Surg 1991; 78: 1196-1202
44. Sherman S, Lehman GA ERCP- and endoscopic sphincterotomy-induced pancreatitis. Pancreas 1991; 6: 350-367 [Erratum, Pancreas 1992;7:402.]
45. Bedford RA, Johnson GK, Geenen JE, Does the use of non-ionic contrast prevent post-ERCP pancreatitis? Results of a prospective multicenter study. Gastrointest Endosc 1993; 39: 315-315 abstract.
46. Sherman S, Troiano FP, Hawes RH, Lehman GA Sphincter of Oddi manometry: decreased risk of clinical pancreatitis with use of a modified aspirating catheter. Gastrointest Endosc 1990; 36: 462-466
47. White MT, Morgan A, Hopton D Postoperative pancreatitis: a study of seventy cases. Am J Surg 1970; 120: 132-137
48. Bragg LE, Thompson JS, Burnett DA, Hodgson PE, Rikkers LF Increased incidence of pancreas-related complications in patients with postoperative pancreatitis. Am J Surg 1985; 150: 694-697
49. Fernandez-del Castillo C, Harringer W, Warshaw AL, Risk factors for pancreatic cellular injury after cardiopulmonary bypass. N Engl J Med 1991; 325: 382-387
50. Toskes PP Hyperlipidemic pancreatitis. Gastroenterol Clin North Am 1990; 19: 783-791
51. Izsak EM, Shike M, Roulet M, Jeejeebhoy KN Pancreatitis in association with hypercalcemia in patients receiving total parenteral nutrition. Gastroenterology 1980; 79: 555-558
52. Gafter U, Mandel EM, Har Zahav L, Weiss S Acute pancreatitis secondary to hypercalcemia: occurrence in a patient with breast carcinoma. JAMA 1976; 235: 2004-2005
53. Mixter CG Jr, Keynes WM, Cope O Further experience with pancreatitis as a diagnostic clue to hyperparathyroidism. N Engl J Med 1962; 266: 265-272
54. Shearer MG, Imrie CW Parathyroid hormone levels, hyperparathyroidism and acute pancreatitis. Br J Surg 1986; 73: 282-284
55. Kattwinkel J, Lapey A, Di Sant'Agnese PA, Edwards WA Hereditary pancreatitis: three new kindreds and a critical review of the literature. Pediatrics 1973; 51: 55-69
56. Feldstein JD, Johnson FR, Kallick CA, Doolas A Acute hemorrhagic pancreatitis and pseudocyst due to mumps. Ann Surg 1974; 180: 85-88
57. Imrie CW, Ferguson JC, Sommerville RG Coxsackie and mumpsvirus infection in a prospective study of acute pancreatitis. Gut 1977; 18: 53-56
58. Lopez Morante A, Rodriguez de Lope C, San Miguel G, Pons Romero F Acute pancreatitis in hepatitis A infection. Postgrad Med J 1986; 62: 407-408
59. Joe L, Ansher AF, Gordin FM Severe pancreatitis in an AIDS patient in association with cytomegalovirus infection. South Med J 1989; 82: 1444-1445
60. Dowell SF, Moore GW, Hutchins GM The spectrum of pancreatic pathology in patients with AIDS. Mod Pathol 1990; 3: 49-53
61. Wilcox CM, Forsmark CE, Grendell JH, Darragh TM, Cello JP Cytomegalovirus-associated acute pancreatic disease in patients with acquired immunodeficiency syndrome: report of two patients. Gastroenterology 1990; 99: 263-267
62. Cappell MS, Hassan T Pancreatic disease in patients with the acquired immunodeficiency syndrome. Pract Gastroenterol 1993; 17: 18-24
63. Lefor AT, Vuocolo P, Parker FB Jr, Sillin LF Pancreatic complications following cardiopulmonary bypass: factors influencing mortality. Arch Surg 1992; 127: 1225-1231
64. McKay JW, Baggenstoss AH, Wollaeger EE Infarcts of the pancreas. Gastroenterology 1958; 35: 256-264
65. Serrano Lopez MC, Yebra Bango M, Lopez Bonet E, Acute pancreatitis and systemic lupus erythematosus: necropsy of a case and review of the pancreatic vascular lesions. Am J Gastroenterol 1991; 86: 764-767
66. Warshaw AL, Lesser PB Amylase clearance in differentiating acute pancreatitis from peptic ulcer with hyperamylasemia. Ann Surg 1975; 181: 314-316
67. Legge DA, Hoffman HN II, Carlson HC Pancreatitis as a complication of regional enteritis of the duodenum. Gastroenterology 1971; 61: 834-837
68. Jordan CS, Ament ME Pancreatitis in children and adolescents. J Pediatr 1977; 91: 211-216
69. Weizman Z, Durie PR Acute pancreatitis in childhood. J Pediatr 1988; 113: 24-29
70. Ziegler DW, Long JA, Philippart AI, Klein MD Pancreatitis in childhood: experience with 49 patients. Ann Surg 1988; 207: 257-261
71. Buntain WL, Wood JB, Woolley MM Pancreatitis in childhood. J Pediatr Surg 1978; 13: 143-149
72. Tam PKH, Saing H, Irving IM, Lister J Acute pancreatitis in children. J Pediatr Surg 1985; 20: 58-60
73. Lee SP, Nicholls JF, Park HZ Biliary sludge as a cause of acute pancreatitis. N Engl J Med 1992; 326: 589-593
74. Ros E, Navarro S, Bru C, Garcia-Puges A, Valderrama R Occult microlithiasis in idiopathic' acute pancreatitis: prevention of relapses by cholecystectomy or ursodeoxycholic acid therapy. Gastroenterology 1991; 101: 1701-1709
75. Cotton PB Pancreas divisum — curiosity or culprit? Gastroenterology 1985; 89: 1431-1435
76. McLatchie GR, Imrie CW Acute pancreatitis associated with tumor metastases in the pancreas. Digestion 1981; 21: 13-17
77. Haber CJ, Meltzer SJ, Present DH, Korelitz BI Nature and course of pancreatitis caused by 6-mercaptopurine in the treatment of inflammatory bowel disease. Gastroenterology 1986; 91: 982-986
78. Mofenson HC, Caraccio TR, Nawaz H, Steckler G Acetaminophen induced pancreatitis. J Toxicol Clin Toxicol 1991; 29: 223-230
79. Schwartz MS, Brandt LJ The spectrum of pancreatic disorders in patients with the acquired immune deficiency syndrome. Am J Gastroenterol 1989; 84: 459-462
80. Meiselman MS, Agha FP Fistula to the pancreatic duct from a peptic ulcer: case report and literature review. J Clin Gastroenterol 1988; 10: 537-540
81. Lerch MM, Saluja AK, Dawra R, Saluja M, Steer ML The effect of chloroquine administration on two experimental models of acute pancreatitis. Gastroenterology 1993; 104: 1768-1779
82. Klar E, Messmer K, Warshaw AL, Herfarth C Pancreatic ischaemia in experimental acute pancreatitis: mechanism, significance and therapy. Br J Surg 1990; 77: 1205-1210
83. Figarella C, Amouric M, Guy-Crotte O. Enzyme activation and liberation: intracellular/extracellular events. In: Beger HG, Buchler M, eds. Acute pancreatitis: research and clinical management. Berlin, Germany: Springer-Verlag, 1987:53-60.
84. Nevalainen TJ, Aho HJ. Phospholipase A in acute pancreatitis. In: Beger HG, Buchler M, eds. Acute pancreatitis: research and clinical management. Berlin, Germany: Springer-Verlag, 1987:71-8.
85. Buchler M, Malfertheiner P, Schadlich H, Nevalainen TJ, Friess H, Beger HG Role of phospholipase A in human acute pancreatitis. Gastroenterology 1989; 97: 1521-1526
86. Foulis AK, Murray WR, Galloway D, Endotoxaemia and complement activation in acute pancreatitis in man. Gut 1982; 23: 656-661
87. Whicher JT, Barnes MP, Brown A, Complement activation and complement control proteins in acute pancreatitis. Gut 1982; 23: 944-950
88. Balldin G. Release of vasoactive substances in ascites and blood in acute pancreatitis. In: Berger HG, Buchler M, eds. Acute pancreatitis: research and clinical management. Berlin, Germany: Springer-Verlag, 1987:63-70.
89. Beger HG, Bittner R, Block S, Buchler M Bacterial contamination of pancreatic necrosis: a prospective clinical study. Gastroenterology 1986; 91: 433-438
90. Gerzof SG, Banks PA, Robbins AH, Early diagnosis of pancreatic infection by computed tomography-guided aspiration. Gastroenterology 1987; 93: 1315-1320
91. Bittner R, Block S, Buchler M, Beger HG Pancreatic abscess and infected pancreatic necrosis: different local septic complications in acute pancreatitis. Dig Dis Sci 1987; 32: 1082-1087
92. Gullo L, Priori P, Labo G. Natural history of acute pancreatitis and its relationship to chronic pancreatitis. In: Banks PA, Porro GB, eds. Acute pancreatitis: advances in pathogenesis, diagnosis and treatment. Milan, Italy: Masson Italia Editori, 1984:87-9.
93. Marks IN, Girdwood AH, Bornman PC, Feretis C. The prevalence and etiology of pancreatitis in Cape Town. In: Gyr KE, Singer M, Sarles H, eds. Pancreatitis: concepts and classification. Amsterdam: Elsevier Science, 1984:371-3.
94. Cameron JL, Capuzzi DM, Zuidema GD, Margolis S Acute pancreatitis with hyperlipemia: the incidence of lipid abnormalities in acute pancreatitis. Ann Surg 1973; 177: 483-489
95. Moody FG, Senninger N, Runkel N Another challenge to the Opie myth. Gastroenterology 1993; 104: 927-931
96. Elman R, Arneson N, Graham EA Value of blood amylase estimations in the diagnosis of pancreatic disease: a clinical study. Arch Surg 1929; 19: 943-967
97. Steinberg WM, Goldstein SS, Davis ND, Shamma'a J, Anderson K Diagnostic assays in acute pancreatitis: a study of sensitivity and specificity. Ann Intern Med 1985; 102: 576-580
98. Wilson C, Imrie CW Deaths from acute pancreatitis: why do we miss the diagnosis so frequently? Int J Pancreatol 1988; 3: 273-281
99. Lankisch PG, Schirren CA, Kunze E Undetected fatal acute pancreatitis: why is the disease so frequently overlooked? Am J Gastroenterol 1991; 86: 322-326
100. Pieper-Bigelow C, Strocchi A, Levitt MD Where does serum amylase come from and where does it go? Gastroenterol Clin North Am 1990; 19: 793-810
101. Gumaste V, Dave P, Sereny G Serum lipase: a better test to diagnose acute alcoholic pancreatitis. Am J Med 1992; 92: 239-242
102. Gwozdz GP, Steinberg WM, Werner M, Henry JP, Pauley C Comparative evaluation of the diagnosis of acute pancreatitis based on serum and urine enzyme assays. Clin Chim Acta 1990; 187: 243-254
103. Gumaste VV, Dave PB, Weissman D, Messer J Lipase/amylase ratio: a new index that distinguishes acute episodes of alcoholic from nonalcoholic acute pancreatitis. Gastroenterology 1991; 101: 1361-1366
104. Tenner SM, Steinberg W The admission serum lipase:amylase ratio differentiates alcoholic from nonalcoholic acute pancreatitis. Am J Gastroenterol 1992; 87: 1755-1758
105. Pezzilli R, Billi P, Miglioli M, Gullo L Serum amylase and lipase concentrations and lipase/amylase ratio in assessment of etiology and severity of acute pancreatitis. Dig Dis Sci 1993; 38: 1265-1269
106. Neoptolemos JP, Hall AW, Finlay DF, Berry JM, Carr-Locke DL, Fossard DP The urgent diagnosis of gallstones in acute pancreatitis: a prospective study of three methods. Br J Surg 1984; 71: 230-233
107. McKay AJ, Imrie CW, O'Neill J, Duncan JG Is an early ultrasound scan of value in acute pancreatitis? Br J Surg 1982; 69: 369-372
108. Balthazar EJ CT diagnosis and staging of acute pancreatitis. Radiol Clin North Am 1989; 27: 19-37
109. Ranson JHC, Balthazar E, Caccavale R, Cooper M Computed tomography and the prediction of pancreatic abscess in acute pancreatitis. Ann Surg 1985; 201: 656-665
110. Kivisaari L, Somer K, Standertskjold-Nordenstam C-G, Schroder T, Kivilaakso E, Lempinen M Early detection of acute fulminant pancreatitis by contrast-enhanced computed tomography. Scand J Gastroenterol 1983; 18: 39-41
111. A new method for the diagnosis of acute hemorrhagic-necrotizing pancreatitis using contrast-enhanced CT, L., Kivisaari, K., Somer, C.-G., Standertskjold-Nordenstam, T., Schroder, E., Kivilaakso, M., Lempinen, Gastrointest Radiol, (1984), 9, 27-30
112. Nuutinen P, Kivisaari L, Schroder T Contrast-enhanced computed tomography and microangiography of the pancreas in acute human hemorrhagic/ necrotizing pancreatitis. Pancreas 1988; 3: 53-60
113. Block S, Maier W, Bittner R, Buchler M, Malfertheiner P, Beger HG Identification of pancreas necrosis in severe acute pancreatitis: imaging procedures versus clinical staging. Gut 1986; 27: 1035-1042
114. London NJM, Leese T, Lavelle JM, Rapid-bolus contrast-enhanced dynamic computed tomography in acute pancreatitis: a prospective study. Br J Surg 1991; 78: 1452-1456
115. Cotton PB, Beales JSM Endoscopic pancreatography in management of relapsing acute pancreatitis. BMJ 1974; 1: 608-611
116. Ranson JHC, Rifkind KM, Roses DF, Fink SD, Eng K, Spencer FC Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974; 139: 69-81
117. Ranson JHC Etiological and prognostic factors in human acute pancreatitis: a review. Am J Gastroenterol 1982; 77: 633-638
118. Larvin M, McMahon MJ APACHE-II score for assessment and monitoring of acute pancreatitis. Lancet 1989; 2: 201-205
119. Wilson C, Heath DI, Imrie CW Prediction of outcome in acute pancreatitis: a comparative study of APACHE II, clinical assessment and multiple factor scoring systems. Br J Surg 1990; 77: 1260-1264
120. Steinberg WM Predictors of severity of acute pancreatitis. Gastroenterol Clin North Am 1990; 19: 849-861
121. Puolakkainen PA Early assessment of acute pancreatitis: a comparative study of computed tomography and laboratory tests. Acta Chir Scand 1989; 155: 25-30
122. Wilson C, Heads A, Shenkin A, Imrie CW C-reactive protein, antiproteases and complement factors as objective markers of severity in acute pancreatitis. Br J Surg 1989; 76: 177-181
123. Gudgeon AM, Heath DI, Hurley P, Trypsinogen activation peptides assay in the early prediction of severity of acute pancreatitis. Lancet 1990; 335: 4-8
124. Mayer AD, McMahon MJ The diagnostic and prognostic value of peritoneal lavage in patients with acute pancreatitis. Surg Gynecol Obstet 1985; 160: 507-512
125. McMahon MJ, Pickford IR, Playforth MJ Early prediction of severity of acute pancreatitis using peritoneal lavage. Acta Chir Scand 1980; 146: 171-175
126. Clavien PA, Hauser H, Meyer P, Rohner A Value of contrast-enhanced computerized tomography in the early diagnosis and prognosis of acute pancreatitis: a prospective study of 202 patients. Am J Surg 1988; 155: 457-466
127. Beger HG, Buchler M, Bittner R, Block S, Nevalainen T, Roscher R Necrosectomy and postoperative local lavage in necrotizing pancreatitis. Br J Surg 1988; 75: 207-212
128. Funnell IC, Bornman PC, Weakley SP, Terblanche J, Marks IN Obesity: an important prognostic factor in acute pancreatitis. Br J Surg 1993; 80: 484-486
129. Ranson JHC, Spencer FC Prevention, diagnosis, and treatment of pancreatic abscess. Surgery 1977; 82: 99-106
130. Buggy BP, Nostrant TT Lethal pancreatitis. Am J Gastroenterol 1983; 78: 810-814
131. Pederzoli P, Bassi C, Vesentini S, Campedelli A A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg Gynecol Obstet 1993; 176: 480-483
132. Renner IG, Savage WT III, Pantoja JL, Renner VJ Death due to acute pancreatitis: a retrospective analysis of 405 autopsy cases. Dig Dis Sci 1985; 30: 1005-1018
133. Beger HG Surgery in acute pancreatitis. Hepatogastroenterology 1991; 38: 92-96
134. Simpson WG, Schwartz RW, Strodel WE Splenic vein thrombosis. South Med J 1990; 83: 417-421
135. Bivins BA, Sachatello CR, Chuang VP, Brady P Hemosuccus pancreaticus (hemoductal pancreatitis): gastrointestinal hemorrhage due to rupture of a splenic artery aneurysm into the pancreatic duct. Arch Surg 1978; 113: 751-753
136. Boon P, de Reuck J, Achten E, de Bleeker J Pancreatic encephalopathy: a case report and review of the literature. Clin Neurol Neurosurg 1991; 93: 137-141
137. Semlacher EA, Chan-Yan C Acute pancreatitis presenting with visual disturbance. Am J Gastroenterol 1993; 88: 756-759
138. Aldridge MC, Francis ND, Glazer G, Dudley HA Colonic complications of severe acute pancreatitis. Br J Surg 1989; 76: 362-367
139. Lankisch PG The spleen in inflammatory pancreatic disease. Gastroenterology 1990; 98: 509-516
140. Valderrama R, Perez-Mateo M, Navarro S, Multicenter double-blind trial of gabexate mesylate (FOY) in unselected patients with acute pancreatitis. Digestion 1992; 51: 65-70
141. Levant JA, Secrist DM, Resin H, Sturdevant RAL, Guth PH Nasogastric suction in the treatment of alcoholic pancreatitis: a controlled study. JAMA 1974; 229: 51-52
142. Naeije R, Salingret E, Clumeck N, De Troyer A, Devis G Is nasogastric suction necessary in acute pancreatitis? BMJ 1978; 2: 659-660
143. Loiudice TA, Lang J, Mehta H, Banta L Treatment of acute alcoholic pancreatitis: the roles of cimetidine and nasogastric suction. Am J Gastroenterol 1984; 79: 553-558
144. Broe PJ, Zinner MJ, Cameron JL A clinical trial of cimetidine in acute pancreatitis. Surg Gynecol Obstet 1982; 154: 13-16
145. Meshkinpour H, Molinari MD, Gardner L, Berk JE, Hoehler FK Cimetidine in the treatment of acute alcoholic pancreatitis: a randomized, double-blind study. Gastroenterology 1979; 77: 687-690
146. Cameron JL, Mehigan D, Zuidema GD Evaluation of atropine in acute pancreatitis. Surg Gynecol Obstet 1979; 148: 206-208
147. Death from acute pancreatitis: MR.C. multicentre trial of glucagon and aprotinin. Lancet 1977; 2: 632-635
148. Waterworth MW, Barbezat GO, Bank S Glucagon in treatment of acute pancreatitis. Lancet 1974; 1: 1231-1231
149. Durr HK, Maroske D, Zedler O, Bode JC Glucagon therapy in acute pancreatitis: report of a double-blind trial. Gut 1978; 19: 175-179
150. Kronborg O, Bulow S, Joergensen PM, Svendsen LB A randomized double-blind trial of glucagon in treatment of first attack of severe acute pancreatitis without associated biliary disease. Am J Gastroenterol 1980; 73: 423-425
151. Saario IA 5-Fluorouracil in the treatment of acute pancreatitis. Am J Surg 1983; 145: 349-352
152. Usadel KH, Uberla KK, Leuschner U Treatment of acute pancreatitis with somatostatin: results of the multicenter double-blind trial (APTS-study). Dig Dis Sci 1985; 30: 992-992 abstract.
153. Choi TK, Mok F, Zhan WH, Fan ST, Lai EC, Wong J Somatostatin in the treatment of acute pancreatitis: a prospective randomised controlled trial. Gut 1989; 30: 223-227
154. Goebell H, Ammann R, Herfarth C, A double-blind trial of synthetic salmon calcitonin in the treatment of acute pancreatitis. Scand J Gastroenterol 1979; 14: 881-889
155. Foulis AK Morphological study of the relation between accidental hypothermia and acute pancreatitis. J Clin Pathol 1982; 35: 1244-1248
156. Finch WT, Sawyers JL, Schenker S A prospective study to determine the efficacy of antibiotics in acute pancreatitis. Ann Surg 1976; 183: 667-671
157. Craig RM, Dordal E, Myles L The use of ampicillin in acute pancreatitis. Ann Intern Med 1975; 83: 831-832
158. Howes R, Zuidema GD, Cameron JL Evaluation of prophylactic antibiotics in acute pancreatitis. J Surg Res 1975; 18: 197-200
159. Imrie CW, Benjamin IS, Ferguson JC, A single-center double-blind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg 1978; 65: 337-341
160. Trapnell JE, Rigby CC, Talbot CH, Duncan EH A controlled trial of Trasylol in the treatment of acute pancreatitis. Br J Surg 1974; 61: 177-182
161. Trapnell JE, Talbot CH, Chir M, Capper WM Trasylol in acute pancreatitis. Am J Dig Dis 1967; 12: 409-412
162. Skyring A, Singer A, Tornya P Treatment of acute pancreatitis with Trasylol: report of a controlled therapeutic trial. BMJ 1965; 2: 627-629
163. Larvin M, Wilson C, Heath D, Alexander D, McMahon MJ, Imrie CW A prospective, multi-center, randomised trial of intra-peritoneal anti-protease therapy for acute pancreatitis. Gastroenterology 1992; 102: Suppl: A274-A274 abstract.
164. Buchler M, Malfertheiner P, Uhl W, Gabexate mesilate in human acute pancreatitis: German Pancreatitis Study Group. Gastroenterology 1993; 104: 1165-1170
165. Leese T, Holliday M, Heath D, Hall AW, Bell PR Multicentre clinical trial of low volume fresh frozen plasma therapy in acute pancreatitis. Br J Surg 1987; 74: 907-911
166. Sax HC, Warner BW, Talamini MA, Early total parenteral nutrition in acute pancreatitis: lack of beneficial effects. Am J Surg 1987; 153: 117-124
167. Ihse I, Evander A, Gustafson I, Holmberg JT Influence of peritoneal lavage on objective prognostic signs in acute pancreatitis. Ann Surg 1986; 204: 122-127
168. Mayer AD, McMahon MJ, Corfield AP, Controlled clinical trial of peritoneal lavage for the treatment of severe acute pancreatitis. N Engl J Med 1985; 312: 399-404
169. Ranson JHC, Berman RS Long peritoneal lavage decreases pancreatic sepsis in acute pancreatitis. Ann Surg 1990; 211: 708-716
170. Kelly TR, Wagner DS Gallstone pancreatitis: a prospective randomized trial of the timing of surgery. Surgery 1988; 104: 600-605
171. Stone HH, Fabian TC, Dunlop WE Gallstone pancreatitis: biliary tract pathology in relation to time of operation. Ann Surg 1981; 194: 305-312
172. Neoptolemos JP, Carr-Locke DL, London NJ, Bailey IA, James D, Fossard DP Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet 1988; 2: 979-983
173. Kivilaakso E, Lempinen M, Makelainen A, Nikki P, Schroder T Pancreatic resection versus peritoneal lavation for acute fulminant pancreatitis: a randomized prospective study. Ann Surg 1984; 199: 426-431
174. Schroder T, Sainio V, Kivisaari L, Puolakkainen P, Kivilaakso E, Lempinen M Pancreatic resection versus peritoneal lavage in acute necrotizing pancreatitis: a prospective randomized trial. Ann Surg 1991; 214: 663-666
175. Steinberg WM, Schlesselman SE Treatment of acute pancreatitis: comparison of animal and human studies. Gastroenterology 1987; 93: 1420-1427
176. Wall AJ Peritoneal dialysis in the treatment of severe acute pancreatitis. Med J Aust 1965; 2: 281-283
177. Buchler M, Malfertheiner P, Friess H, Human pancreatic tissue concentration of bactericidal antibiotics. Gastroenterology 1992; 103: 1902-1908
178. Senn J. The surgery of the pancreas. Philadelphia: W.J. Doran, 1886:71-107.
179. Rattner DW, Legermate DA, Lee MJ, Mueller PR, Warshaw AL Early surgical debridement of symptomatic pancreatic necrosis is beneficial irrespective of infection. Am J Surg 1992; 163: 105-109
180. D'Egidio A, Schein M Surgical strategies in the treatment of pancreatic necrosis and infection. Br J Surg 1991; 78: 133-137
181. Karimgani I, Porter KA, Langevin RE, Banks PA Prognostic factors in sterile pancreatic necrosis. Gastroenterology 1992; 103: 1636-1640
182. Bradley EL III, Allen K A prospective longitudinal study of observation versus surgical intervention in the management of necrotizing pancreatitis. Am J Surg 1991; 161: 19-24
183. Wilson C, McArdle CS, Carter DC, Imrie CW Surgical treatment of acute necrotizing pancreatitis. Br J Surg 1988; 75: 1119-1123
184. Machado MCC, Bacchella T, Monteiro da Cunha JE, Surgical treatment of pancreatic necrosis. Dig Dis Sci 1986; 31: Suppl: 25S-25S abstract.