Structured model of genetic control via the lac promoter in Escherichia coli

Biotechnology and Bioengineering

Volumn 43, Issue 5, 1994, Pages 399-410

  Laffend, L ^a,b   Shuler, M L ^a  

^a Department of Obstetrics Gynecology   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

Escherichia coli; genetic control; lac based promoters

Indexed keywords

BACTERIA; BIOTECHNOLOGY; MODELS; PROTEINS;

ESCHERICHIA COLI; GENETIC CONTROL; LAC BASED PROMOTER;

GENETIC ENGINEERING;

ARTICLE; ESCHERICHIA COLI; GENE CONTROL; LACTOSE OPERON; NONHUMAN; PROMOTER REGION;

EID: 0028764952     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.260430508     Document Type: Article

References (64)

1. Vectors bearing a hybrid trp‐lac promoter useful for regulated expression of cloned genes in Escherichia coli.
2. A mathematical model for the prediction of plasmid copy number and genetic stability in Escherichia coli.
3. Linkage map of Escherichia coli K‐12
4. Maximizing gene expression on a plasmid using recombination in vitro.
5. The lactose operon
6. Mechanisms of mRNA decay in bacteria: a perspective
7. Chemical structure and functional organization of lac repressor from Escherichia coli
8. Modulation of chemical composition and other parameters of the cell by growth rate
9. Evidence that the 5′ end of lac mRNA starts to decay as soon as it is synthesized
10. Transcription of single‐copy hybrid lacZ genes by T7 RNA polymerase in Escherichia coli: mRNA synthesis and degradation can be uncoupled from translation
11. Simultaneous regulation of plasmid replication and heterologous gene expression in Escherichia coli.
12. Changes in the half‐life of ribosomal protein mRNA caused by translational repression
13. Allosteric regulation of inducer and operator binding to the lactose repressor
14. Continuous, high level, production and excretion of a plasmid‐encoded protein by Escherichia coli in a two‐stage chemostat
15. The lactose repressor
16. Direct experssion in Escherichia coli of a DNA sequence coding for human growth hormone
17. Modeling the role of cyclic AMP in catabolite repression of inducible enzyme biosynthesis in microbial cells
18. Studies on the induction of β‐galactosidase in a cryptic strain of Escherichia coli.
19. A kinetic model of catabolite repression in the dual control mechanism in microorganisms
20. Genetic regulatory mechanisms in the synthesis of proteins
21. Molecular biology of active transport: from membrane to molecule to mechanism
22. Nonspecific DNA binding of genome‐regulating proteins as a biological control mechanism: measurement of DNA‐bound Escherichia coli lac repressor in vivo.
23. Transcription and translation initiation frequencies of the Escherichia coli lac operon
24. Analysis of pBR322 replication kinetics and its dependency on growth rate
25. A structured, segregated model for genetically modified Escherichia coli cells and its use for prediction of plasmid stability
26. Processing of RNA transcripts
27. The role of permease in transport
28. Mechanism of ‘inducer exclusion’ by glucose
29. Mathematical modeling of induced foreign protein production by recombinant bacteria
30. Genetically structured models for lac promoter‐operator function in the Escherichia coli chromosome and in multicopy plasmids: lac operator function
31. Genetically structured models for lac promoter‐operator function in the Escherichia coli chromosome and in multicopy plasmids: lac promoter function
32. Models for decay of Escherichia coli messenger RNA and evidence for inactivating cleavages between its messages
33. Mechanism and control of transcription initiation in prokaryotes
34. lacZ translation initiation mutations
35. Transcription and decay of the lac messenger: role of an intergenic terminator
36. DNA binding characteristics of lactose repressor and the trypsin resistant core repressor
37. Equilibrium binding of inducer to lac repressor operator DNA complex
38. DNA replication regulated by the priming promoter
39. Mutations in the leader sequence and initiation condon of the gene for ribosomal protein S20 (rpsT) affect both translational efficiency and autoregulation
40. The functional stability of the lacZ transcript is sensitive towards sequence alterations immediately downstream of the ribosome binding site
41. Multiple determinants of functional mRNA stability: sequence alterations at either end of the lacZ gene affect the rate of mRNA inactivation
42. Regulation of lac operon expression in mixed sugar chemostat cultures
43. The lac promoter
44. A general method for maximizing the expression of a cloned gene
45. Protein phosphorylation and the allosteric control of inducer exclusion and catabolite repression by the bacterial phosphoenolpyruvate: sugar phosphotransferase system
46. Sugar transport: inducer exclusion and the regulation of the melobiose, maltose, glycerol, and lactose transport systems by the phosphoenolpyruvate: sugar phosphotransferase system
47. Intracellular equilibrium calculations based on small systems thermodynamics
48. Stability of ribosomal protein mRNA and translational feedback regulation in Escherichia coli.
49. Theoretical study of tryptophan operon: application in microbial technology
50. Inefficient translation initiation causes premature transcription termination in the lacZ gene
51. Dual control of invertase biosynthesis in chemostat culture
52. Effects of plasmid copy number and runaway plasmid replication on overproduction and excretion of β‐lactamase from Escherichia coli.
53. Role of cyclic AMP in bacteria
54. Cell growth and extracellular enzyme synthesis in fermentations
55. The role of energy coupling in the transport of β‐galactosides by Escherichia coli.
56. Inhibition of β‐galactoside transport by substrates of the glucose transport system in Escherichia coli.
57. Lactose carrier protein of Escherichia coli: interaction with galactosides and protons
58. Effect of chemically‐induced, cloned‐gene expression on protein synthesis in E. coli.
59. β‐Galactosidase, the lactose permease protein, and thiogalactoside transacetylase